<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2024000400007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Malformaciones congénitas en hijos de madres diabéticas en la provincia de Cienfuegos. 2016-2019]]></article-title>
<article-title xml:lang="en"><![CDATA[Congenital malformations in children of diabetic mothers in the province of Cienfuegos. 2016-2019]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arbolay Sanabria]]></surname>
<given-names><![CDATA[Fanny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera Fragoso]]></surname>
<given-names><![CDATA[Lázaro Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos Solís]]></surname>
<given-names><![CDATA[Maylé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barberis Pérez]]></surname>
<given-names><![CDATA[Gladis Bárbara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Senra]]></surname>
<given-names><![CDATA[Walkiria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vilches León]]></surname>
<given-names><![CDATA[María Soledad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Cienfuegos  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2024</year>
</pub-date>
<volume>22</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2024000400007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2024000400007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2024000400007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  se ha demostrado la relación entre las alteraciones del desarrollo y el pobre control de glucosa en la patogénesis de las malformaciones congénitas.  Objetivo:  identi&#64257;car las malformaciones congénitas en hijos de madres diabéticas.  Métodos:  se realizó un estudio observacional, descriptivo transversal en embarazadas diabéticas cuyos hijos presentaron malformaciones, en la provincia Cienfuegos durante el periodo 2016-2019. Se estudiaron las variables edad materna, índice de masa corporal, tipo de diabetes, su tratamiento, tipo de malformación, resultados ultrasonográficos de los tres trimestres del embarazo, estudio de alfafetoproteínas y amniocentesis.  Resultados:  en la población estudiada el mayor porciento de las madres presentó diabetes mellitus gestacional; predominaron las madres entre 20 y 35 años y un gran número de ellas con sobrepeso. El mayor número de defectos congénitos fueron diagnosticados en el ultrasonido del segundo trimestre (más del 90 %). Los tratamientos más usados por las gestantes fueron la dieta y la insulina. Las malformaciones congénitas mayores constituyeron el mayor porciento y el sistema más afectado fue el cardiovascular.  Conclusiones:  la diabetes mellitus y el sobrepeso continúan siendo factores de riesgo para las malformaciones congénitas, por lo que reducirlos en las mujeres en edad reproductiva y planificar el embarazo es importante en la prevención de la diabetes materna y su repercusión para el producto de la concepción.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Foundation: the relationship between developmental alterations and poor glucose control in the pathogenesis of congenital malformations has been demonstrated.  Objective: to identify congenital malformations in children of diabetic mothers.  Methods: an observational, descriptive cross-sectional study was carried out on diabetic pregnant women whose children had malformations, in the province of Cienfuegos during the period 2016-2019. The variables maternal age, body mass index, type of diabetes, its treatment, type of malformation, ultrasonographic results of the three trimesters of pregnancy, alpha-fetoprotein study and amniocentesis were studied.  Results: in the studied population the highest percentage of mothers presented gestational diabetes mellitus; Mothers between 20 and 35 years old predominated and a large number of them were overweight. The largest number of birth defects were diagnosed at the second trimester ultrasound (more than 90%). The treatments most used by pregnant women were diet and insulin. Major congenital malformations constituted the largest percentage and the most affected system was the cardiovascular system.  Conclusions: diabetes mellitus and overweight continue to be risk factors for congenital malformations, so reducing them in women of reproductive age and planning pregnancy is important in the prevention of maternal diabetes and its impact on the product of conception.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diabetes gestacional]]></kwd>
<kwd lng="es"><![CDATA[índice de masa corporal]]></kwd>
<kwd lng="es"><![CDATA[anomalías congénitas]]></kwd>
<kwd lng="es"><![CDATA[ultrasonografía prenatal]]></kwd>
<kwd lng="en"><![CDATA[diabetes, gestational]]></kwd>
<kwd lng="en"><![CDATA[body mass index]]></kwd>
<kwd lng="en"><![CDATA[congenital abnormalities]]></kwd>
<kwd lng="en"><![CDATA[ultrasonography, prenatal]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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