<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2020000100063</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores pronósticos de mortalidad en pacientes ancianos con sepsis en cuidados intensivos]]></article-title>
<article-title xml:lang="en"><![CDATA[Prognostic factors for mortality in elderly patients admitted to intensive care units with sepsis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Oliva]]></surname>
<given-names><![CDATA[Mijail]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Jiménez]]></surname>
<given-names><![CDATA[Airon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Padrón Mora]]></surname>
<given-names><![CDATA[Maidolys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Fleites]]></surname>
<given-names><![CDATA[Gabriel de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leyva Hernández]]></surname>
<given-names><![CDATA[Annis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Docente Clínico Quirúrgico &#8220;Aleida Fernández Chardiet&#8221;  ]]></institution>
<addr-line><![CDATA[Mayabeque ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2020</year>
</pub-date>
<volume>19</volume>
<numero>1</numero>
<fpage>63</fpage>
<lpage>75</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2020000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2020000100063&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2020000100063&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La sepsis fue definida como una disfunción orgánica potencialmente mortal causada por una respuesta desregulada del huésped a la infección.  Objetivo: Identificar factores pronósticos de mortalidad en pacientes con 65 años o más ingresados con sepsis en la Unidad de Cuidados Intensivos del Hospital &#8220;Aleida Fernández Chardiet&#8221; entre 2012-2017.  Material y Métodos:  Se realizó un estudio observacional, analítico y retrospectivo. La población objeto de estudio fue de 129 pacientes con 65 años o más que ingresaron con sepsis.  Resultados:  Ingresaron 316 pacientes con sepsis; 187 con &#706; 65 años y 129 tenían &#8805;65 años. Los valores de media del APACHE II fue muy superior en los pacientes que no lograron sobrevivir (16,1; p&#706;0,01); al igual que el SOFA (6,3±2,4; IC 95% 5,8-6,8; p&#706;0,01). La curva ROC mostró un área bajo la curva para el APACHE II es de 0,834 (IC 95% 0,761-0,907) y para el SOFA es de 0,941 (IC 95% 0,903-0,980). El 77,6% de los pacientes que murieron presentaban un shock séptico (OR=47,5; IC 95% 13,2-170,5; p&#706;0,01); y un síndrome de disfunción múltiple de órganos, 67,1% (OR=47,8; IC 95% 9,6-189,5; p&#706;0,01). Las variables significativamente asociadas a la mortalidad fueron el APACHE II&#8805;15 puntos (OR ajustado 10,7; IC 95% 2,8-40,4) y el SOFA &#8805;5 puntos (OR ajustado 43,9; IC 95% 2,3-826,8). La calibración del modelo fue adecuada (X2=5,7; p=0,336).  Conclusiones:  Los factores pronósticos que se relacionaron con la mortalidad en los ancianos fueron el APACHE II&#8805; 15 puntos y el SOFA &#8805;5 puntos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Sepsis is defined as a life-threatening organ dysfunction caused by an unregulated host response to infection.  Objective: To identify prognostic factors for mortality in patients 65 years old or older admitted with sepsis to the Intensive Care Unit of &#8220;Aleida Fernandez Chardiet&#8221; Teaching General Hospital between 2012 and 2017.  Material and Methods: An observational analytical retrospective study was conducted. The study population was 129 elderly patients who were diagnosed with sepsis.  Results:  A total of 316 patients were admitted with sepsis; 187 of them were under 65 years old and 129 were 65 years old or older. The average APACHE II scores were much higher in those patients who could not survive (161; p&#706;0, 01); SOFA scores were (6, 3±2,4; 95% CI 5,8-6,8; p&#706;0,01). The ROC curve showed an area under the curve for APACHE II which was found to be 0,834 (95% CI 0,761-0,907) and for SOFA it was 0,941 (95% CI 0,903-0,980). On the other hand, 77,6% of patients died with septic shock (OR=47,5; 95% CI 13,2-170,5; p&#706;0,01) and a multiple-organ dysfunction syndrome, which was observed in 67,1% of them (OR=47,8; 95% CI 9,6-189,5; p&#706;0,01). According to multivariate logistic regression model, the variables significantly associated to mortality were APACHE II score &#8805;15 points (adjusted OR 10, 7; 95% CI 2, 8-40, 4) and SOFA &#8805;5 points (adjusted OR 43, 9; 95% CI 2, 3-826, 8). The model calibration was adequate (X2=5,7; p=0,336).  Conclusions:  The prognostic factors for mortality in elderly patients admitted with sepsis in the service were as follows: APACHE II score &#8805; 15 points and SOFA score &#8805;5 points.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sepsis]]></kwd>
<kwd lng="es"><![CDATA[factores pronósticos]]></kwd>
<kwd lng="es"><![CDATA[ancianos]]></kwd>
<kwd lng="es"><![CDATA[mortalidad]]></kwd>
<kwd lng="es"><![CDATA[cuidados intensivos]]></kwd>
<kwd lng="en"><![CDATA[Sepsis]]></kwd>
<kwd lng="en"><![CDATA[prognostic factors]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
<kwd lng="en"><![CDATA[mortality]]></kwd>
<kwd lng="en"><![CDATA[intensive care]]></kwd>
</kwd-group>
</article-meta>
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