<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2021000600011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome hemofagocítico secundario a infección por virus del dengue]]></article-title>
<article-title xml:lang="en"><![CDATA[Hemophagocytic syndrome secondary to dengue virus infection]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Andres Portes]]></surname>
<given-names><![CDATA[Jhonatan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fiesco Sepúlveda]]></surname>
<given-names><![CDATA[Karen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Medina Rojas]]></surname>
<given-names><![CDATA[Gorety]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad surcolombiana  ]]></institution>
<addr-line><![CDATA[Huila ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital &#8220;San Francisco de Asís&#8221;  ]]></institution>
<addr-line><![CDATA[Huila ]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Universitario &#8220;Hernando Moncaleano Perdomo&#8221;  ]]></institution>
<addr-line><![CDATA[Huila ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>20</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2021000600011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2021000600011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2021000600011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El síndrome hemofagocítico se presenta como un cuadro clínico grave, provocado por una respuesta inadecuada del sistema inmunológico a un desencadenante infeccioso, neoplásico, reumatológico o metabólico, que origina una reacción inflamatoria no controlada; presenta una incidencia baja pero la letalidad sin el manejo adecuado es muy elevada.  Objetivo:  Destacar la importancia de diagnóstico oportuno del síndrome hemofagocítico en pacientes con dengue que presentan evolución tórpida.  Presentación del caso:  Paciente de 7 años de edad, con dengue grave dado por shock, hepatomegalia con elevación de transaminasas, con mala evolución clínica, quien cumple criterios de Síndrome hemofagocítico. Recibió manejo con inmunomoduladores con evolución satisfactoria.  Conclusiones:  Es importante considerar el Síndrome hemofagocítico como causa ante enfermedades con evolución tórpida a pesar de tener un manejo médico correcto.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Hemophagocytic syndrome is a severe clinical picture with an uncontrolled inflammatory reaction caused by an inadequate immune system response to an infectious, neoplastic, rheumatological, or metabolic trigger. The syndrome has low incidence but high fatality when the management is not adequate.  Objective:  To highlight the importance of a prompt diagnosis of hemophagocytic syndrome in patients with dengue who present a torpid evolution.  Case presentation:  Seven-year-old patient with severe dengue caused by shock, hepatomegaly with elevated transaminase levels and poor clinical evolution who meets hemophagocytic syndrome criteria. The patient had satisfactory progression after receiving immunomodulatory treatment.  Conclusions:  Hemophagocytic syndrome must be considered as a cause of pathologies in dengue patients with torpid evolution, even when correct medical management is made.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Síndrome hemofagocítico]]></kwd>
<kwd lng="es"><![CDATA[hemofagocitosis]]></kwd>
<kwd lng="es"><![CDATA[dengue grave]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico oportuno]]></kwd>
<kwd lng="es"><![CDATA[evolución tórpida]]></kwd>
<kwd lng="en"><![CDATA[Hemophagocytic syndrome]]></kwd>
<kwd lng="en"><![CDATA[hemophagocytosis]]></kwd>
<kwd lng="en"><![CDATA[severe dengue]]></kwd>
<kwd lng="en"><![CDATA[prompt diagnosis]]></kwd>
<kwd lng="en"><![CDATA[torpid evolution]]></kwd>
</kwd-group>
</article-meta>
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<article-title xml:lang=""><![CDATA[Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: Experiences From 180 Patients With Severe Dengue]]></article-title>
<source><![CDATA[Clinical Infectious Diseases]]></source>
<year>2020</year>
<volume>70</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>2247-55</page-range></nlm-citation>
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</back>
</article>
