<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2022000100004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto de Spirulina maxima sobre la memoria espacial en Rattus norvegicus var. albinus]]></article-title>
<article-title xml:lang="en"><![CDATA[Effect of Spirulina maxima on spatial memory in Rattus norvegicus var. albinus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Vega]]></surname>
<given-names><![CDATA[Juan Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Ishimine]]></surname>
<given-names><![CDATA[Richard Fredy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campos Reyna]]></surname>
<given-names><![CDATA[Jorge Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mejía Pinedo]]></surname>
<given-names><![CDATA[Davis Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lora Loza]]></surname>
<given-names><![CDATA[Miryam Griselda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Calderón Mundaca]]></surname>
<given-names><![CDATA[Wilmer Leoncio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional de Trujillo Escuela de Post Grado ]]></institution>
<addr-line><![CDATA[Trujillo ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Pedro Ruiz Gallo Facultad de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[Lambayeque ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2022</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2022000100004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La memoria es un proceso fisiológico que se activa por estímulos externos, es necesaria para modificar la conducta, adaptación al medio y la diferenciación del modelo animal. Este proceso complejo que involucra no sólo a las redes sinápticas sino otros mecanismos neurofisiológicos, suele ser estimulado por algunos nutraceúticos.  Objetivo:  Evaluar el efecto de Spirulina maxima sobre la memoria espacial en Rattus norvegicus var. albinus  Material y Métodos: Se desarrolló un diseño de estímulo creciente donde se ordenaron cuatro grupos con 5 ratas cada uno, se agruparon en grupos Tratamiento I, II y III; a los que se les dio por vía oral Spirulina maxima a diferentes concentraciones y el grupo testigo sin tratamiento, se valoró la memoria espacial en el laberinto acuático de Morris.  Resultados:  Las ratas presentaron un tiempo de latencia equivalente para desarrollar la fase de adquisición y de retención, se registraron tiempos promedio; al aplicar la dosis 200 y 400 mg/kg no varían los índices de aprendizaje entre sí; y ante la dosis de concentración más alta 800 mg/kg se observó una disminución leve del tiempo de latencia de la fase de adquisición. De acuerdo con la prueba ANOVA hubo poca diferencia.  Conclusiones: Hubo efecto de la Spirulina maxima en la memoria espacial del sujeto experimental, evidenciable en la duración de la conducta motora en el laberinto acuático de Morris, a través de índices de aprendizaje los cuales presentaron modificación favorable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Memory is a physiological process that is activated by external stimuli. It is necessary for behavior modification, adaptation to the environment, and differentiation in the animal model. This complex process that involves not only synaptic networks but other neurophysiological mechanisms, is usually stimulated by some nutraceuticals.  Objective:  To evaluate the effect of Spirulina maxima on spatial memory in Rattus norvegicus var. albinus.  Material and Methods:  An increasing stimulus design was developed. Four similar groups of 5 rats were arranged and grouped into treatment I, II and III groups which were given Spirulina maxima orally at different concentrations; the control group did not received treatment. Spatial memory was assessed using the Morris water maze.  Results:  The rats presented an equal latency time to develop the acquisition and the retention phases; average times were recorded; the learning rates did not differ from each other at doses of 200 and 400 mg / kg; at the highest concentration dose of 800 mg / kg, there was a slight decrease in the latency time during the acquisition phase. There was a slight difference according to the ANOVA test.  Conclusions:  There was an effect of Spirulina maxima on the spatial memory of the experimental subject, which was evident in the duration of the motor behavior in the Morris water maze through learning rates which presented a favorable modification.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Aprendizaje]]></kwd>
<kwd lng="es"><![CDATA[memoria espacial]]></kwd>
<kwd lng="es"><![CDATA[spirulina maxima]]></kwd>
<kwd lng="en"><![CDATA[Learning]]></kwd>
<kwd lng="en"><![CDATA[spatial memory]]></kwd>
<kwd lng="en"><![CDATA[Spirulina maxima.]]></kwd>
</kwd-group>
</article-meta>
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