<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2022000200005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Avances en la inmunopatogenia de la hepatitis autoinmune]]></article-title>
<article-title xml:lang="en"><![CDATA[Advances in the immunopathogenesis of autoimmune hepatitis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[La Rosa Hernández]]></surname>
<given-names><![CDATA[Deyanira]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castellanos Fernández]]></surname>
<given-names><![CDATA[Marlen Ivon]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Gastroenterología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2022000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2022000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2022000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  en la hepatitis autoinmune los mecanismos inmunopatogénicos no están totalmente esclarecidos, múltiples son las investigaciones en este campo, con vistas a enriquecer los conocimientos y ampliar las opciones terapéuticas.  Objetivo:  sintetizar los conocimientos más recientes acerca de la inmunopatogenia de esta enfermedad.  Material y Método:  se efectúa una búsqueda exhaustiva de la bibliografía disponible en SciELO, ScienceDirect, Google Académico y PubMed, incluyendo artículos de revisión, estudios experimentales, clínicos, de cohorte y metaanálisis.  Desarrollo:  se explican los principales mecanismos de tolerancia central y periférica, así como el papel de las subpoblaciones linfoides, las citocinas y el microambiente en la patogenia de la enfermedad.  Conclusiones:  los avances en el conocimiento de la inmunopatogenia de la hepatitis autoinmune permiten una mejor comprensión de esta enfermedad y son el referente para el diseño de estrategias futuras de tratamiento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Immunopathogenic mechanisms are not fully clarified in autoimmune hepatitis; there are many investigations in this field with a view to enriching knowledge and expanding therapeutic options.  Objective: To synthesize the most recent knowledge about the immunopathogenesis of this disease.  Material and Methods:  An exhaustive search of the bibliography available in SciELO, ScienceDirect, Google Scholar and PubMed was carried out, including review articles, experimental, clinical, cohort and meta-analysis studies.  Development:  The main mechanisms of central and peripheral tolerance are explained, as well as the role of lymphoid subpopulations, cytokines and the microenvironment in the pathogenesis of the disease.  Conclusions:  Advances in the knowledge of the immunopathogenesis of autoimmune hepatitis allow a better understanding of this disease and are the referents in the design of future treatment strategies.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hepatitis autoinmune]]></kwd>
<kwd lng="es"><![CDATA[tolerancia hepática]]></kwd>
<kwd lng="es"><![CDATA[células presentadoras de antígenos]]></kwd>
<kwd lng="es"><![CDATA[subpoblaciones linfoides]]></kwd>
<kwd lng="es"><![CDATA[autoanticuerpos]]></kwd>
<kwd lng="es"><![CDATA[microbiota intestinal]]></kwd>
<kwd lng="en"><![CDATA[autoimmune hepatitis]]></kwd>
<kwd lng="en"><![CDATA[liver tolerance]]></kwd>
<kwd lng="en"><![CDATA[antigen presenting cells]]></kwd>
<kwd lng="en"><![CDATA[lymphoid subpopulations]]></kwd>
<kwd lng="en"><![CDATA[autoantibodies]]></kwd>
<kwd lng="en"><![CDATA[gut microbiota]]></kwd>
</kwd-group>
</article-meta>
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<source><![CDATA[Journal Clinical Laboratory Analysis]]></source>
<year>2020</year>
<volume>34</volume>
<numero>12</numero>
<issue>12</issue>
</nlm-citation>
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</back>
</article>
