<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1729-519X</journal-id>
<journal-title><![CDATA[Revista Habanera de Ciencias Médicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev haban cienc méd]]></abbrev-journal-title>
<issn>1729-519X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de la Habana]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1729-519X2022000200006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre intensidad de la ventilación mecánica y agravamiento de la disfunción multiorgánica por la COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Relationship between intensity of mechanical ventilation and multiple organ dysfunction worsening by COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado Serrano]]></surname>
<given-names><![CDATA[Raúl de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Oliva]]></surname>
<given-names><![CDATA[Mijail]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico Docente &#8220;Aleida Fernández Chardiet&#8221;  ]]></institution>
<addr-line><![CDATA[Mayabeque ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1729-519X2022000200006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1729-519X2022000200006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1729-519X2022000200006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La intensidad de la ventilación mecánica está reflejada por la presión de conducción dinámica y el poder mecánico. Es un predictor de lesión pulmonar inducida por el ventilador y está asociada a la mortalidad.  Objetivo:  Determinar si existe relación entre intensidad de la ventilación mecánica y el &#916;SOFA&gt;0 (agravamiento) en los pacientes con la COVID-19 a las 72 horas después de la intubación.  Material y Métodos:  Grupo de estudio conformado por 35 pacientes diagnosticados con la COVID-19 que estuvieron ventilados por más de 72 horas. Se empleó la prueba de Chi cuadrado (X  2 ) o test exacto de Fisher para comparar variables cualitativas; para las cuantitativas se empleó la prueba t de Student o U de Mann-Whitney. Se realizó una Regresión Logística Binaria Simple para encontrar relación de las variables con &#916;SOFA dicotomizada para &#916;SOFA&#8804;0 y &#916;SOFA&gt;0. La capacidad discriminativa de los modelos se evaluó mediante la Curva ROC.  Resultados:  Presentaron SOFA&gt;0 21 pacientes (60 %). No se encontraron diferencias significativas de la Presión de Conducción entre ambos grupos (15 vs. 18, U=94.00, z= -1,795, p=0,77). Fueron buenas predictoras de &#916;SOFA&gt;0 el Poder Mecánico (OR 3,421 [95 % IC1,510 a 7,750, p=0,003]) y el Volumen Tidal (OR 1,03 [95 % IC 1,012 a 1,068], p=0,005). El Modelo Predictivo de &#916;SOFA&gt;0 en función del Poder Mecánico (AUC 0,888 [95 % IC 0,775 a 1], p&lt;0,001) mostró una buena capacidad discriminatoria.  Conclusiones:  El Poder Mecánico está relacionado con el agravamiento de la disfunción multiorgánica en pacientes sometidos a ventilación mecánica por la COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The intensity of mechanical ventilation is reflected by driving pressure and mechanical power. It is a predictor of ventilator-induced lung injury and it can be associated with mortality.  Objective:  To determine if there is a relationship between intensity of mechanical ventilation and &#916;SOFA&gt;0 (worsening) in patients with COVID-19 at 72 h after intubation.  Material and Methods:  Study group composed of 35 COVID-19 patients who were ventilated for more than 72 hours. Chi-square test (X  2 ) or Fisher&#8217;s exact test was used to compare qualitative variables; Student t test or Mann-Whitney U test was employed for quantitative ones. A Simple Binary Logistic Regression Model was performed in order to find the relationship between variables and dichotomized &#916;SOFA for &#916;SOFA&#8804;0 and &#916;SOFA&gt;0. The discriminatory capacity of the models was tested by using ROC Curve.  Results:  A total of 21 patients (60 %) presented &#916;SOFA&gt;0 (worsening). No significant differences related to Driving Pressure were found between the two groups (15 vs. 18, U=94,00, z= -1,795, p=0,77). Mechanical Power (OR 3,421 [95 % CI 1,510 a 7,750, p=0,003]) and Tidal Volume (OR 1,03 [95 % CI 1,012 a 1,068], p=0,005) were good predictors of &#916;SOFA&gt;0. The Predictive Model of &#916;SOFA&gt;0 depending on Mechanical Power (AUC 0,888 [95 % CI 0,775 a 1], p&lt;0,001) showed a good discriminatory capacity.  Conclusions:  Mechanical Power is related to multi-organ dysfunction worsening in mechanically ventilated patients with COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Poder Mecánico]]></kwd>
<kwd lng="es"><![CDATA[presión de conducción]]></kwd>
<kwd lng="es"><![CDATA[delta SOFA]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Mechanical power]]></kwd>
<kwd lng="en"><![CDATA[driving pressure]]></kwd>
<kwd lng="en"><![CDATA[delta SOFA]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
</kwd-group>
</article-meta>
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