<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1815-5944</journal-id>
<journal-title><![CDATA[Ingeniería Mecánica]]></journal-title>
<abbrev-journal-title><![CDATA[Ingeniería Mecánica]]></abbrev-journal-title>
<issn>1815-5944</issn>
<publisher>
<publisher-name><![CDATA[Facultad de Ingeniería Mecánica. Instituto Superior Politécnico "José Antonio Echeverría"]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1815-59442021000200012</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Análisis de la confiabilidad de procesos en una empresa biofarmacéutica]]></article-title>
<article-title xml:lang="en"><![CDATA[Process reliability analysis a biopharmaceutical industry]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Concepción]]></surname>
<given-names><![CDATA[Armando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Muñoz-González]]></surname>
<given-names><![CDATA[Edisbel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alfonso-Álvarez]]></surname>
<given-names><![CDATA[Alexander]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González- González]]></surname>
<given-names><![CDATA[Aleida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Martínez]]></surname>
<given-names><![CDATA[Igor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Soto]]></surname>
<given-names><![CDATA[Ángel Alexander]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Tecnológica de La Habana José Antonio Echeverría Centro de Estudios en Ingeniería de Mantenimiento, CEIM ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Nacional de Biopreparados. BioCubaFarma  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de La Serena Facultad de Ingeniería Departamento de Ingeniería Mecánica]]></institution>
<addr-line><![CDATA[La Serena ]]></addr-line>
<country>Chile</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Tecnológica de La Habana José Antonio Echeverría Facultad de Ingeniería Industrial ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Pontificia Universidad Católica de Valparaíso Escuela de Ingeniería Mecánica ]]></institution>
<addr-line><![CDATA[Valparaíso ]]></addr-line>
<country>Chile</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>24</volume>
<numero>2</numero>
<fpage>12</fpage>
<lpage>18</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1815-59442021000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1815-59442021000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1815-59442021000200012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[Resumen La confiabilidad de procesos y sistemas es un elemento fundamental dentro del Análisis de la Confiabilidad operacional. Esta investigación tuvo como objetivo analizar la confiabilidad del sistema de llenado de bulbos en una empresa biofarmacéutica a partir de un nuevo modelo matemático. Los modelos publicados para evaluar la confiabilidad de proceso no tienen en cuenta la integración de los elementos: logística, calidad y la organización, quedando superada esta insuficiencia en el nuevo modelo. Los métodos principales empleados fueron: la modelación matemática para la evaluación de la confiabilidad y sus componentes y el estadístico para la obtención de los datos. La investigación se realizó en el periodo comprendido entre los años 2017 al 2019. El resultado principal es que la variable aprovechamiento de la instalación tuvo el mayor impacto en los resultados siendo la propuesta implementar un mejor uso a la capacidad instalada.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[Abstract System and process reliability is a key element in the Operational Reliability analysis. The objective of this research was to analyze the reliability of the vial filling system in a biopharmaceutical industry based on a new mathematical model. The published models to evaluate process reliability do not take into account the integration of the elements: logistics, quality and organization, this inadequacy in the new model are overcome. The main methods applied were mathematical modeling for the assessment of reliability and its components and the statistic for obtaining data. The research was carried out between the years 2017 and 2019. The main result is that the variable Use of the Installation had the greatest impact on the results, being the proposal to implement better use of the installed capacity. Results demonstrate that capacity utilization had the most important impact on the outcomes. The findings support the proposal to improve the capacity utilization of the installed facilities.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[confiabilidad operacional]]></kwd>
<kwd lng="es"><![CDATA[confiabilidad de procesos y sistemas]]></kwd>
<kwd lng="es"><![CDATA[modelo matemático]]></kwd>
<kwd lng="es"><![CDATA[logística]]></kwd>
<kwd lng="es"><![CDATA[calidad y organización]]></kwd>
<kwd lng="en"><![CDATA[operational reliability]]></kwd>
<kwd lng="en"><![CDATA[process and system reliability]]></kwd>
<kwd lng="en"><![CDATA[mathematical model]]></kwd>
<kwd lng="en"><![CDATA[logistics]]></kwd>
<kwd lng="en"><![CDATA[quality and organization]]></kwd>
</kwd-group>
</article-meta>
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