<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962018000300006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eficacia del ácido hialurónico en el tratamiento de las enfermedades articulares]]></article-title>
<article-title xml:lang="en"><![CDATA[Usefulness of hyaluronic acid in the treatment of joint diseases]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Abal]]></surname>
<given-names><![CDATA[Sara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soto González]]></surname>
<given-names><![CDATA[Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Vigo Campus A Xunqueira Facultad de Fisioterapia ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>España</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>20</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962018000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962018000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962018000300006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El ácido hialurónico (AH) es un polímero lineal con un elevado peso molecular que se encuentra en gran abundancia en el líquido sinovial, y le proporciona sus propiedades viscoelásticas. La viscosuplementación consiste en administrar inyecciones intraarticulares de soluciones viscoelásticas de hialuronato con el objetivo de restaurar las propiedades elásticas y viscosas del líquido sinovial y así reconstruir la homeostasis alterada en distintas estructuras enfermas como la articulación osteoartrósica.  Objetivo:  La finalidad de esta revisión es conocer la eficacia del tratamiento por vía intraarticular con ácido hialurónico en las enfermedades articulares.  Métodos:  Se llevó a cabo una revisión sistematizada de la bibliografía en las bases de datos Medline, Scopus y PubMed durante los meses de febrero y marzo de 2018. Los términos de búsqueda empleados fueron &#8220;Hyaluronic Acid&#8221; y &#8220;Joint Diseases&#8221;. Se obtuvieron 2 414 resultados, y se seleccionaron 12 artículos atendiendo a los criterios de inclusión y exclusión.  Resultados:  De los 12 artículos seleccionados, 8 son estudios prospectivos, 3 son ensayos clínicos y 1 es un estudio observacional. La mayoría de ellos busca valorar la eficacia del ácido hialurónico en el dolor y la funcionalidad en diferentes enfermedades como son la osteoartritis de rodilla, de cadera, de tobillo o de la articulación temporo-mandibular (ATM); el síndrome de choque fémoroacetabular y en la artroscopia tanto de la muñeca como de la rodilla.  Conclusiones:  Las inyecciones de ácido hialurónico por vía intrarticular parecen ser un tratamiento beneficioso para aliviar el dolor y mejorar la funcionalidad que se observa en diferentes enfermedades articulares, pero estos efectos no son permanentes. Sería interesante realizar en el futuro investigaciones controladas para poder estipular las dosis y los pesos moleculares más adecuados y observar también los efectos a largo plazo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Hyaluronic acid (HA) is a linear polymer with high molecular weight that is found in great abundance in the synovial fluid and provides it with its viscoelastic properties. Viscosupplementation consists in the intrarticular administration of injections of viscoelastic hyaluronate solutions to restore the elastic and viscous properties of the synovial fluid and thus repair the altered homeostasis in different pathological structures such as the osteoarthritic joint.  Objective: The purpose of this review is to know the efficacy of treatment with intrarticular administration of hyaluronic acid in joint diseases.  Methods: A systematic review of the bibliography was carried out in the databases Medline, Scopus and PubMed, during the months of February and March 2018. The search terms used were Hyaluronic Acid and Joint Diseases. We obtained 2414 results and selected 12 articles based on the inclusion and exclusion criteria.  Results: Of the 12 articles selected, eight are prospective studies, 3 are clinical trials and 1 is an observational study. Most of them aimed at assessing the effectiveness of AH in pain and functionality in different diseases such as osteoarthritis of the knee (OA), hip, ankle or temporomandibular joint (TMJ), the femoroacetabular shock syndrome and in both wrist and knee arthroscopy.  Conclusions: Intrarticular injections of AH seem to be a beneficial treatment to relieve pain and improve functionality in different joint diseases, but these effects are not permanent. It would be interesting to conduct future controlled research in order to determine the most appropriate doses and molecular weights, and also to observe the long-term effects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácido hialurónico]]></kwd>
<kwd lng="es"><![CDATA[enfermedades articulares]]></kwd>
<kwd lng="es"><![CDATA[inyección]]></kwd>
<kwd lng="es"><![CDATA[osteoartrosis]]></kwd>
<kwd lng="en"><![CDATA[hyaluronic acid]]></kwd>
<kwd lng="en"><![CDATA[joint diseases]]></kwd>
<kwd lng="en"><![CDATA[injections]]></kwd>
<kwd lng="en"><![CDATA[osteoarthritis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Quintero]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<source><![CDATA[Osteoartrosis: biología, fisiopatología, clínica y tratamiento]]></source>
<year>2010</year>
<publisher-loc><![CDATA[Buenos Aires ]]></publisher-loc>
<publisher-name><![CDATA[Editorial Médica Panamericana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fuentes Arderiu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Castiñeiras Lacambra]]></surname>
<given-names><![CDATA[MJ]]></given-names>
</name>
<name>
<surname><![CDATA[Queraltó Compañó]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioquímica clínica y patología molecular]]></source>
<year>1998</year>
<publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[Reverté]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balazs]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Laurent]]></surname>
<given-names><![CDATA[TC]]></given-names>
</name>
<name>
<surname><![CDATA[Jeanloz]]></surname>
<given-names><![CDATA[RW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nomenclature of hyaluronic acid]]></article-title>
<source><![CDATA[Biochem J]]></source>
<year>1986</year>
<volume>235</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>903</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Alonso]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Villanueva]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aplicaciones clínicas y efectos terapéuticos de la viscosuplementación en la artrosis de rodilla]]></article-title>
<source><![CDATA[Rev Ortop Traumatol]]></source>
<year>2002</year>
<volume>5</volume>
<page-range>458-64</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balazs]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Denlinger]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Viscosupplementation a new concept in the treatment of osteoarthritis]]></article-title>
<source><![CDATA[J Rheumatol]]></source>
<year>1993</year>
<volume>20</volume>
<numero>39</numero>
<issue>39</issue>
<page-range>3-9</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Santilli]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Paoloni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Mangone]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Alviti]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Bernetti]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hyaluronic acid in the management of osteoarthritis injection therapies innovations]]></article-title>
<source><![CDATA[Clin Cases Miner Bone Metab]]></source>
<year>2016</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>131-4</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balazs]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Denlinger]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sodium hyaluronate acid and joint function]]></article-title>
<source><![CDATA[J Equine Vet Sci]]></source>
<year>1985</year>
<volume>5</volume>
<page-range>217-28</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rydell]]></surname>
<given-names><![CDATA[NW]]></given-names>
</name>
<name>
<surname><![CDATA[Balazs]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of intrarticular injection of hyaluronic acid on the clinical symptoms of osteoarthritis and granulation tissue formation]]></article-title>
<source><![CDATA[Clin Orthop]]></source>
<year>1971</year>
<volume>80</volume>
<page-range>25-32</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Weiss]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Balazs]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[St Onge]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Denlinger]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical studies of the intrarticular injection of HealonR (Sodium hyaluronate) in the treatment of osteoarthritis of human knees]]></article-title>
<source><![CDATA[Arthritis Rheum]]></source>
<year>1981</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>143-4</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Polache]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Selva]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Viscosuplementación revisión de los diferentes hialuronatos en españa]]></article-title>
<source><![CDATA[Farm Hosp]]></source>
<year>2000</year>
<volume>24</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>371-6</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abate]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Scuccimarra]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Vanni]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Pantalone]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Salini]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Femoroacetabular impingement is hyaluronic acid effective?]]></article-title>
<source><![CDATA[Knee Surg Sports Traumatol Arthrosc]]></source>
<year>2014</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>889-92</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Anand]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Singisetti]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Srikanth]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bamforth]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Asumu]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Buch]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effect of Sodium Hyaluronate on Recovery after Arthroscopic Knee Surgery]]></article-title>
<source><![CDATA[J Knee Surg]]></source>
<year>2015</year>
<volume>29</volume>
<numero>06</numero>
<issue>06</issue>
<page-range>502-9</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arden]]></surname>
<given-names><![CDATA[NK]]></given-names>
</name>
<name>
<surname><![CDATA[Åkermark]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Andersson]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Todman]]></surname>
<given-names><![CDATA[MG]]></given-names>
</name>
<name>
<surname><![CDATA[Altman]]></surname>
<given-names><![CDATA[RD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis]]></article-title>
<source><![CDATA[Curr Med Res Opin]]></source>
<year>2014</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>279-86</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tang AC-W]]></surname>
</name>
<name>
<surname><![CDATA[Tang SF-T]]></surname>
</name>
<name>
<surname><![CDATA[Hong W-H]]></surname>
</name>
<name>
<surname><![CDATA[Chen H-C]]></surname>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Kinetics features changes before and after intrarticular hyaluronic acid injections in patients with knee osteoarthritis]]></article-title>
<source><![CDATA[Clin Neurol Neurosurg]]></source>
<year>2015</year>
<volume>129</volume>
<page-range>21-6</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Diraçoglu]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Tunçay]]></surname>
<given-names><![CDATA[TB]]></given-names>
</name>
<name>
<surname><![CDATA[Sahbaz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Aksoy]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single versus multiple dose hyaluronic acid Comparison of the results]]></article-title>
<source><![CDATA[J Back Musculoskelet Rehabil]]></source>
<year>2016</year>
<volume>29</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>881-6</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guarda-Nardini]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Rossi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ramonda]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Punzi]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ferronato]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Manfredini]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effectiveness of treatment with viscosupplementation in temporomandibular joints with or without effusion]]></article-title>
<source><![CDATA[Int J Oral Maxillofac Surg]]></source>
<year>2014</year>
<volume>43</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1218-23</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Lùrati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Laria]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Mazzocchi]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Re]]></surname>
<given-names><![CDATA[KA]]></given-names>
</name>
<name>
<surname><![CDATA[Marrazza]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Scarpellini]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Effects of hyaluronic acid (HA) viscosupplementation on peripheral Th cells in knee and hip osteoarthritis]]></article-title>
<source><![CDATA[Osteoarthritis Cartilage]]></source>
<year>2015</year>
<volume>23</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>88-93</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Murphy]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Curtin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[McGoldrick]]></surname>
<given-names><![CDATA[NP]]></given-names>
</name>
<name>
<surname><![CDATA[Thong]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Kearns]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prospective Evaluation of Intrarticular Sodium Hyaluronate Injection in the Ankle]]></article-title>
<source><![CDATA[J Foot Ankle Surg]]></source>
<year>2017</year>
<volume>56</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>327-31</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nikose]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gudhe]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Singh]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Arora]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Viscosupplementation in Osteoarthritis of Knee]]></article-title>
<source><![CDATA[Int J Interdiscip Multidiscip Stud]]></source>
<year>2015</year>
<volume>2</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>24-30</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rivera]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single intrarticular injection of high molecular weight hyaluronic acid for hip osteoarthritis]]></article-title>
<source><![CDATA[J Orthop Traumatol]]></source>
<year>2016</year>
<volume>17</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>21-6</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Schütz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Dobner]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Auswirkungen einer intraartikulären Substitutionstherapie mit Hyaluronsäure im Rahmen handgelenksarthroskopischer Operationen Eine randomisierte, kontrollierte, prospektive, unverblindete, monozentrische Vergleichsstudie]]></article-title>
<source><![CDATA[Handchir Mikrochir Plast Chir]]></source>
<year>2013</year>
<volume>45</volume>
<numero>05</numero>
<issue>05</issue>
<page-range>277-84</page-range></nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ucar]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrarticular Hyaluronic Acid as Treatment in Elderly and Middle- Aged Patients with Knee Osteoarthritis]]></article-title>
<source><![CDATA[Open Rheumatol J]]></source>
<year>2013</year>
<volume>7</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>38-41</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cascaes]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Valdivia]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
<name>
<surname><![CDATA[da Rosa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[PJ]]></given-names>
</name>
<name>
<surname><![CDATA[da Silva]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Escalas y listas de evaluación de la calidad de estudios científicos]]></article-title>
<source><![CDATA[Revsta Cuba Inf En Cienc Salud]]></source>
<year>2013</year>
<volume>24</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>295-312</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Cuello]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[No existen pruebas que demuestren que las terapias complementarias o alternativas ayuden en diversas enfermedades pediátricas]]></article-title>
<source><![CDATA[Evid Pediatr]]></source>
<year>2011</year>
<volume>7</volume>
<page-range>86</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hack]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Di Primio]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rakhra]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Beaulé]]></surname>
<given-names><![CDATA[PE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of Cam-Type Femoroacetabular Impingement Morphology in Asymptomatic Volunteers J Bone Jt Surg-Am]]></article-title>
<source><![CDATA[Vol]]></source>
<year>2010</year>
<volume>92</volume>
<numero>14</numero>
<issue>14</issue>
<page-range>2436-44</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leunig]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Podeszwa]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Beck]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Werlen]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ganz]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Magnetic resonance arthrography of labral disorders in hips with dysplasia and impingement]]></article-title>
<source><![CDATA[Clin Orthop]]></source>
<year>2004</year>
<volume>418</volume>
<page-range>74-80</page-range></nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tanzer]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Noiseux]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osseous Abnormalities and Early Osteoarthritis The Role of Hip Impingement]]></article-title>
<source><![CDATA[Clin Orthop]]></source>
<year>2004</year>
<volume>429</volume>
<page-range>170-7</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bijlsma]]></surname>
<given-names><![CDATA[JW]]></given-names>
</name>
<name>
<surname><![CDATA[Berenbaum]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Lafeber]]></surname>
<given-names><![CDATA[FP]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoarthritis an update with relevance for clinical practice]]></article-title>
<source><![CDATA[The Lancet]]></source>
<year>2011</year>
<volume>377</volume>
<numero>9783</numero>
<issue>9783</issue>
<page-range>2115-26</page-range></nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Flouzat-Lachaniette]]></surname>
<given-names><![CDATA[C-H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[At-risk situations for knee osteoarthritis]]></article-title>
<source><![CDATA[Rev Prat]]></source>
<year>2012</year>
<volume>62</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>630-4</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Benítez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Mejía]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resultado de la aplicación de viscosuplementación como tratamiento conservador de gonartrosis grados Il y Ill en el Hospital Regional General Ignacio Zaragoza]]></article-title>
<source><![CDATA[Rev Esp Méd Quir]]></source>
<year>2013</year>
<volume>18</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>45-50</page-range></nlm-citation>
</ref>
<ref id="B31">
<label>31</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Solis]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[de Armas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bacallao]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Osteoartritis Características sociodemográficas]]></article-title>
<source><![CDATA[Rev Cubana Reumatol]]></source>
<year>2014</year>
<volume>16</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>97-103</page-range></nlm-citation>
</ref>
<ref id="B32">
<label>32</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Comas]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Sala]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Román]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Hoffmeistery]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Castells]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Variaciones en la estimación de la prevalencia de artrosis de rodilla según los criterios diagnósticos utilizados en los estudios poblacionales]]></article-title>
<source><![CDATA[Gac Sanit]]></source>
<year>2010</year>
<volume>24</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>28-32</page-range></nlm-citation>
</ref>
<ref id="B33">
<label>33</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Couceiro]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
<name>
<surname><![CDATA[Cotón]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estudio multicéntrico de la eficacia del tratamiento intraarticular con ácido hialurónico (Adant(r)) en artrosis de rodilla]]></article-title>
<source><![CDATA[Rev Esp Reumatol]]></source>
<year>2003</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>57-65</page-range></nlm-citation>
</ref>
<ref id="B34">
<label>34</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Solis]]></surname>
<given-names><![CDATA[U]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Prada]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[de Armas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ulloa]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calidad de vida relacionada con la salud en pacientes con osteoartritis]]></article-title>
<source><![CDATA[Rev Cubana Reumatol]]></source>
<year>2013</year>
<volume>15</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>153-9</page-range></nlm-citation>
</ref>
<ref id="B35">
<label>35</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Monerris]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Martí]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Roca]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Rincón]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Hinojosa]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jiménez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis]]></article-title>
<source><![CDATA[Rev Soc Esp Dolor]]></source>
<year>2012</year>
<volume>19</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>259-63</page-range></nlm-citation>
</ref>
<ref id="B36">
<label>36</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López Alonso]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Sánchez]]></surname>
<given-names><![CDATA[CM]]></given-names>
</name>
<name>
<surname><![CDATA[Romero Cañadillas]]></surname>
<given-names><![CDATA[AB]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro Casado]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[González Rojo]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Propiedades métricas del cuestionario WOMAC y de una versión reducida para medir la sintomatología y la discapacidad física]]></article-title>
<source><![CDATA[Aten Primaria]]></source>
<year>2009</year>
<volume>41</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>613-20</page-range></nlm-citation>
</ref>
<ref id="B37">
<label>37</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castañeda]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Kuroiwa]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Castañeda]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Manche-Kuroiwa]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Priori]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluación de la eficacia y seguridad del ácido hialurónico por vía oral asociado con glucosamina sulfato, condroitín sulfato y metilsulfonilmetano comparado con la asociación por vía oral de glucosamina sulfato, condroitín sulfato y metilsulfonilmetano en la osteoartritis de rodilla]]></article-title>
<source><![CDATA[Acta Médica Perú]]></source>
<year>2014</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>157-64</page-range></nlm-citation>
</ref>
<ref id="B38">
<label>38</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borrás-Verdera]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Calcedo-Bernal]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Ojeda-Levenfeld]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Clavel-Sainz]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eficacia y seguridad de una única inyección intraarticular de ácido hialurónico al 2% más manitol en artrosis de rodilla durante un periodo de 6 meses]]></article-title>
<source><![CDATA[Rev Esp Cir Ortopédica Traumatol]]></source>
<year>2012</year>
<volume>56</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>274-80</page-range></nlm-citation>
</ref>
<ref id="B39">
<label>39</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castellano]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evidencia de la eficacia del ácido hialurónico intraarticular en el tratamiento de la artrosis de rodilla]]></article-title>
<source><![CDATA[Rev Soc Val Reuma]]></source>
<year>2007</year>
<volume>2</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>61-2</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
