<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962019000100008</article-id>
<article-id pub-id-type="doi">10.5281/zenodo.2555337</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Anestesia local en pacientes reumáticos. Avances y perspectivas]]></article-title>
<article-title xml:lang="en"><![CDATA[Local anesthesia in rheumatic patients. Progress and perspectives]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vanegas Mendieta]]></surname>
<given-names><![CDATA[Jenny Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fierro Díaz]]></surname>
<given-names><![CDATA[Gissela Alejandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Beltrán Gallegos]]></surname>
<given-names><![CDATA[Alba Belén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Estatal de Cuenca Universidad San Francisco de Quito Hospital Carlos Andrade Marín]]></institution>
<addr-line><![CDATA[ Pichincha]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Central del Ecuador Universidad San Francisco de Quito Hospital Carlos Andrade Marín]]></institution>
<addr-line><![CDATA[ Pichincha]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Escuela Latinoamericana de Medicina Universidad San Francisco de Quito Hospital Carlos Andrade Marín]]></institution>
<addr-line><![CDATA[ Pichincha]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962019000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962019000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962019000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  las enfermedades reumáticas y muscoloesqueléticas se manifiestan por alteraciones en el aparato locomotor, aunque detrás de ellas puede haber un trastorno de la respuesta inmunológica que conlleva a que la atención de estos pacientes no se deba centrar solo en los aspectos locales, sino también en su valoración sistémica por la afectación de órganos y sistemas de órganos como el cardiovascular, respiratorio, renal y digestivo.  Objetivo:  revisar los avances y tendencias actuales del uso de la anestesia local en pacientes con enfermedades reumáticas.  Desarrollo:  el tratamiento de estas enfermedades está constituido fundamentalmente por glucocorticoides los antinflamatorios no esteroideos y los fármacos modificadores de enfermedad, además de que cada vez más están disponibles medicamentos antirreumáticos, aunque algunos aún requieren de mayor evidencia para su utilización generalizada.  Conclusiones:  la anestesia local es una de las alternativas terapéuticas que generalmente, por vía intra articular, se emplea en los pacientes reumáticos, al igual que otros medicamentos. En la búsqueda de nuevas sustancias que induzcan mayores períodos de analgesia se ha incursionado en el empleo de adyuvantes o aditivos, que son medicamentos que se asocian de manera de sinérgica con los anestésicos locales y prolongan la duración del bloqueo sensorio-motor, atenuando la sensación dolorosa y esto permite restringir la dosis acumulativa requerida de anestésicos locales. Se reportan importantes avances en este sentido y se amplían las perspectivas por los resultados de las investigaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  rheumatic diseases and musculoskeletal diseases are manifested by alterations in the locomotors system, although behind them there may be a disorder of the immune response that leads to the attention of these patients should not focus only on the local aspects, but also in its systemic assessment for the involvement of organs and organ systems such as cardiovascular, respiratory, renal and digestive.  Objective:  To review current advances and trends in the use of local anesthesia in patients with rheumatic diseases.  Development:  The treatment of these diseases consists mainly of glucocorticoids, non-steroidal antiinflammatory drugs and disease modifying drugs, in addition to which antirheumatic drugs are increasingly available, although some still require more evidence for its widespread use.  Conclusions:  Local anesthesia is one of the therapeutic alternatives that is generally used intraarticularly in rheumatic patients, as well as other medications. In the search for new substances that induce longer periods of analgesia has been intruded into the use of adjuvants or additives, which are drugs that are associated in a synergistic manner with local anesthetics and prolong the duration of sensorimotor block, attenuating the sensation painful and this allows to restrict the required cumulative dose of local anesthetics. Important advances are reported in this regard and perspectives are broadened by the results of the investigations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedades reumáticas]]></kwd>
<kwd lng="es"><![CDATA[terapéutica]]></kwd>
<kwd lng="es"><![CDATA[anestesia local]]></kwd>
<kwd lng="es"><![CDATA[adyuvantes de anestesia local]]></kwd>
<kwd lng="es"><![CDATA[perspectivas investigativas]]></kwd>
<kwd lng="en"><![CDATA[rheumatic diseases]]></kwd>
<kwd lng="en"><![CDATA[therapeutic]]></kwd>
<kwd lng="en"><![CDATA[local anesthesia]]></kwd>
<kwd lng="en"><![CDATA[adjuvants of local anesthesia]]></kwd>
<kwd lng="en"><![CDATA[investigative perspectives]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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