<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962019000100012</article-id>
<article-id pub-id-type="doi">10.5281/zenodo.2555184</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Granulomatosis de Wegener, una afección poco frecuente]]></article-title>
<article-title xml:lang="en"><![CDATA[Quality of life related to health in patients with osteoarthritis of the Riobamba canton]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yambay Latta]]></surname>
<given-names><![CDATA[Mónica Fabiola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Solorzano Vela]]></surname>
<given-names><![CDATA[Jorge Stalin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Facultad de Salud Pública Carrera de Medicina ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Andino Chimborazo  ]]></institution>
<addr-line><![CDATA[Riobamba Chimborazo]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962019000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962019000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962019000100012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la granulomatosis de Wegener es una vasculitis sistémica, poco frecuente, cuyo sustrato etiopatogénico es la inflamación de los vasos sanguíneos impidiendo la libre circulación del flujo sanguíneo. Clinicamente se caracteriza por presencia de manifestaciones respiratorias, nasales, auditivas y renales; frecuentemente se asocian trastornos infecciosos y alérgicos.  Objetivo:  socializar los principales elementos etiopatogénicos, manifestaciones clínicas y exámenes complementarios que permiten definir el granulomatosis de Wegener.  Caso clínico:  se presenta el caso de una paciente de 32 años de edad la cual es referida desde la atención primaria de salud, por presentar manifestaciones clínicas y de laboratorio que permiten confirmar el diagnóstico de una granulomatosis de Wegener. Conclusiones: la granulomatosis de Wegener es una rara enfermedad que, aunque se presenta fundamentalmente en pacientes femeninas entre 40 y 50 años, puede presentarse en pacientes de cualquier edad sin distinguir preferencia por el sexo. Sus principales manifestaciones clínicas son la toma respiratoria y renal acompañada de manifestaciones generales. El uso de esteroides constituye la piedra angular del tratamiento, al cual se adicionan medicamentos para el control de la enfermedad como es el caso del methotrexate.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Wegener's granulomatosis is a rare systemic vasculitis, whose etiopathogenic substrate is the inflammation of the blood vessels, preventing the free circulation of blood flow. Clinically it is characterized by the presence of respiratory, nasal, auditory and renal manifestations; Infectious and allergic disorders are frequently associated.  Objective:  to socialize the main etiopathogenic elements, clinical manifestations and complementary examinations that allow us to define Wegener's granulomatosis.  Clinical case:  the case of a 32-year-old female patient is reported from primary health care, due to clinical and laboratory manifestations that confirm the diagnosis of Wegener's granulomatosis.  Conclusions:  Wegener's granulomatosis is a rare disease that, although it occurs mainly in female patients between 40 and 50 years, can occur in patients of any age without distinguishing preference for sex. Its main clinical manifestations are respiratory and renal uptake accompanied by general manifestations. The use of steroids is the cornerstone of the treatment, to which are added medications for the control of the disease such as methotrexate.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[calidad de vida]]></kwd>
<kwd lng="es"><![CDATA[granulomatosis de Wegener]]></kwd>
<kwd lng="es"><![CDATA[vasculitis sistémica]]></kwd>
<kwd lng="en"><![CDATA[quality of life]]></kwd>
<kwd lng="en"><![CDATA[Wegener's granulomatosis]]></kwd>
<kwd lng="en"><![CDATA[systemic vasculitis]]></kwd>
</kwd-group>
</article-meta>
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