<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962019000200005</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Systemic Lupus Erythematosus, Ten years of follow up]]></article-title>
<article-title xml:lang="es"><![CDATA[Lupus Eritematoso Sistémico. 10 años de Seguimiento]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez Marrero]]></surname>
<given-names><![CDATA[Witjal Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vizcaino Luna]]></surname>
<given-names><![CDATA[Yanelis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fusté Jiménez]]></surname>
<given-names><![CDATA[Celestino]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez Marrero]]></surname>
<given-names><![CDATA[William Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Otero]]></surname>
<given-names><![CDATA[Zoe Alina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández García]]></surname>
<given-names><![CDATA[Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,University of Medical Sciences of Villa Clara Arnaldo Milián Castro Clinical Surgical University Hospital Department of Internal Medicine and Geriatric Medicine]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Medical Sciences of Villa Clara Santa Clara Clinic ]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,University of Medical Sciences of Villa Clara Division of Pediatric Rheumatology José Luis Miranda Pediatric University Hospital Department of Pediatric Cardiology]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962019000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962019000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962019000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Systemic Lupus Erythematosus is a relatively frequent disease of universal distribution. Its incidence varies according to the characteristics of the studied population such as age, gender and ethno. It is a chronic and autoimmune disease, which cause is not clear at all.  Objective: to characterize clinically and epidemiologically the patients with systemic lupus erythematosus.  Methods:  A descriptive investigation of 112 patients with diagnosis of systemic lupus erythematosus assisted at Arnaldo Milián Castro University Hospital was carried out from January 2008 to December 2017.  Results:  patients between 30 and 39 years of age were the most representative with a higher incidence in the female sex. High blood pressure prevailed as previous history and coffee as toxic habit. There was a higher affection of the osteomyoarticular system followed by skin and mucosa. The combination of Prednisone and Azathioprine was the most used treatment. Infections were the main cause of death.  Conclusions:  systemic Lupus Erythematosus is present with major frequency in female young patients, with a high risk of systemic affection as well as presenting a life-threatening evolution secondary to infections.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: el lupus eritematoso sistémico, es una enfermedad relativamente frecuente y de distribución universal. La incidencia varía según las características de la población estudiada, como la edad, el género y la etnia. Es una enfermedad crónica y autoinmune, cuya causa no está esclarecida del todo.  Objetivo:  caracterizar clínica y epidemiológicamente a los pacientes con lupus eritematoso sistémico.  Métodos:  se realizó una investigación descriptiva de 112 pacientes con diagnóstico de lupus eritematoso sistémico, atendidos en el Hospital Universitario Clínico Quirúrgico Arnaldo Milián Castro, entre enero del 2008 y diciembre del 2017.  Resultados:  los pacientes entre 30 y 39 años de edad fueron los más representativos, con mayor incidencia en el sexo femenino. Predominó la hipertensión arterial como antecedente patológico personal y el café como hábito tóxico. Existió mayor afectación del sistema osteomioarticular seguido por piel y mucosas. La combinación de prednisona y azatioprina fue el tratamiento más usado. La principal causa de muerte fueron las infecciones.  Conclusiones:  el lupus eritematoso sistémico se presenta con mayor frecuencia en pacientes jóvenes y del sexo femenino, con alto riesgo de afectación sistémica así como a presentar evolución tórpida secundaria a infecciones.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[autoimmune]]></kwd>
<kwd lng="en"><![CDATA[autoantibodies]]></kwd>
<kwd lng="en"><![CDATA[aoutoantigens]]></kwd>
<kwd lng="es"><![CDATA[lupus eritematoso sistémico]]></kwd>
<kwd lng="es"><![CDATA[autoinmune]]></kwd>
<kwd lng="es"><![CDATA[autoanticuerpos]]></kwd>
<kwd lng="es"><![CDATA[autoantígenos]]></kwd>
</kwd-group>
</article-meta>
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