<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962019000200007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Medición de la actividad lúpica y daño acumulado en pacientes con lupus eritematoso sistémico]]></article-title>
<article-title xml:lang="en"><![CDATA[Measurement of lupus activity and cumulative damage in patients with systemic lupus erythematosus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vera-Rivero]]></surname>
<given-names><![CDATA[Daniel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chirino-Sánchez]]></surname>
<given-names><![CDATA[Leonel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Lastre]]></surname>
<given-names><![CDATA[Ariel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara Hospital Universitario "Mártires del 9 de Abril" ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara Hospital Universitario "Arnaldo Milián Castro" ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962019000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962019000200007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962019000200007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  medir la actividad de la enfermedad y el daño irreversible en pacientes con lupus eritematoso sistémico es de vital importancia para evaluar las medidas de desenlace del paciente y su pronóstico, las diferencias entre grupos de pacientes y las respuestas a nuevos tratamientos.  Objetivo:  determinar el grado de actividad lúpica y daño acumulado en un grupo de pacientes con lupus eritematoso sistémico.  Método:  se realizó un estudio observacional, descriptivo, de corte transversal, en el Hospital Universitario &#8220;Mártires del 9 de Abril&#8221; de Sagua la Grande, provincia Villa Clara, en el periodo comprendido de enero de 2013 a septiembre de 2018. La muestra, seleccionada de manera no probabilística por criterios, quedó conformada por 53 pacientes con diagnóstico de lupus eritematoso sistémico.  Resultados:  la media de puntajes de la escala MEX-SLEDAI fue de 5.8±3.7 puntos (rango 1-17 puntos). El 37.7 % de los pacientes presentó actividad leve, sólo el 1.9 % presentó actividad muy severa y el 17 % se encontraba en remisión o sin actividad. Los dominios del índice SLICC/ACR más afectados fueron el musculoesquelético (17.0 %), el cardiovascular (17.0 %) y el cutáneo (15.1 %).  Conclusiones:  los pacientes estudiados mostraron un predominio de actividad leve a moderada de la enfermedad según MEX-SLEDAI. La presencia de daño cardiovascular fue superior a la reportada por otros estudios. Se encontró correlación significativa entre la presencia de actividad lúpica y daño acumulado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  measuring the activity of the disease and the irreversible damage in patients with systemic lupus erythematosus is of vital importance to evaluate the outcome measures of the patient and their prognosis, the differences between groups of patients and the responses to new treatments.  Objective:  to determine the degree of lupus activity and accumulated damage in a group of patients with systemic lupus erythematosus.  Method:  an observational, descriptive, cross-sectional study was conducted at the "Mártires del 9 de Abril" University Hospital in Sagua la Grande, Villa Clara province, in the period from January 2013 to September 2018. The sample, selected in a non-probabilistic manner by criteria, was composed of 53 patients with a diagnosis of systemic lupus erythematosus.  Results:  the mean score of the MEX-SLEDAI scale was 5.8 ± 3.7 points (range 1-17 points). 37.7 % of the patients presented mild activity, only 1.9 % presented very severe activity and 17 % were in remission or without activity. The most affected areas of the SLICC / ACR index were musculoskeletal (17.0 %), cardiovascular (17.0 %) and cutaneous (15.1 %).  Conclusions:  the patients studied showed a predominance of mild to moderate disease activity according to MEX-SLEDAI. The presence of cardiovascular damage was higher than that reported by other studies. A significant correlation was found between the presence of lupus activity and accumulated damage.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[lupus eritematoso sistémico]]></kwd>
<kwd lng="es"><![CDATA[actividad de la enfermedad]]></kwd>
<kwd lng="es"><![CDATA[daño]]></kwd>
<kwd lng="es"><![CDATA[MEX-SLEDAI]]></kwd>
<kwd lng="es"><![CDATA[validación]]></kwd>
<kwd lng="en"><![CDATA[systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[disease activity]]></kwd>
<kwd lng="en"><![CDATA[damage]]></kwd>
<kwd lng="en"><![CDATA[MEX-SLEDAI]]></kwd>
<kwd lng="en"><![CDATA[validation]]></kwd>
</kwd-group>
</article-meta>
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