<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962020000400005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Avances en la terapia basada en ácido hialurónico para pacientes con osteoartritis]]></article-title>
<article-title xml:lang="en"><![CDATA[Advances in hyaluronic acid-based therapy for patients with osteoarthritis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Taipe Reinoso]]></surname>
<given-names><![CDATA[Cynthia Estefanía]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guano Sinchiguano]]></surname>
<given-names><![CDATA[Carina Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quisilema Pulupa]]></surname>
<given-names><![CDATA[Cristian Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vallejo Piedra]]></surname>
<given-names><![CDATA[Maura Lilian]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Central del Ecuador  ]]></institution>
<addr-line><![CDATA[Pichincha ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de las Américas  ]]></institution>
<addr-line><![CDATA[Pichincha ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2020</year>
</pub-date>
<volume>22</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962020000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962020000400005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962020000400005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La osteoartritis se considera una de las principales causas de discapacidad funcional. Es una enfermedad crónica y degenerativa que presenta un pico de incidencia en personas mayores de 60 años. El propósito de este trabajo es mostrar los avances en la terapia de pacientes con osteoartritis basada en ácido hialurónico para pacientes con osteoartritis. El ácido hialurónico posee funciones en la articulación que abarcan la lubricación, servir como relleno de espacio para permitir que la articulación permanezca abierta y la regulación de actividades celulares como la unión de proteínas. Cada vez hay más pruebas de que, dentro del espectro de derivados disponibles del ácido hialurónico, la eficacia de los productos de ácido hialurónico con un alto peso molecular es superior a la eficacia de los derivados con un bajo peso molecular. Aprovechando el control espacial de ciertos tipos de hidrogeles de ácido hialurónico, se están desarrollando sistemas de microdispositivos que pueden encapsular células madre embrionarias viables y luego recuperarlas mediante interrupción mecánica. Estas células madre podrían usarse para el tratamiento de enfermedades como la osteoartritis. El ácido hialurónico es un fármaco que puede para ayudar a reducir los efectos secundarios de la osteoartritis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Osteoarthritis is considered one of the main causes of functional disability. Osteoarthritis conceptualized as a chronic and degenerative disease that presents a peak incidence in people older than 60 years. To show advances in hyaluronic acid-based therapy for patients with osteoarthritis. Hyaluronic acid has functions in the joint that include lubrication, which serves as a filling of space to allow the joint to remain open and the regulation of cellular activities such as protein binding. Hyaluronic acid is a potential drug to help reduce the side effects of osteoarthritis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[lubricación]]></kwd>
<kwd lng="es"><![CDATA[ácido hialurónico]]></kwd>
<kwd lng="es"><![CDATA[tratamiento]]></kwd>
<kwd lng="es"><![CDATA[osteoartritis]]></kwd>
<kwd lng="en"><![CDATA[lubrication]]></kwd>
<kwd lng="en"><![CDATA[hyaluronic acid]]></kwd>
<kwd lng="en"><![CDATA[treatment]]></kwd>
<kwd lng="en"><![CDATA[osteoarthritis]]></kwd>
</kwd-group>
</article-meta>
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