<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1817-5996</journal-id>
<journal-title><![CDATA[Revista Cubana de Reumatología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cuba Reumatol]]></abbrev-journal-title>
<issn>1817-5996</issn>
<publisher>
<publisher-name><![CDATA[Editorial CIMEQ]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1817-59962022000100004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores asociados a la aparición de aterosclerosis subclínica en lupus eritematoso sistémico]]></article-title>
<article-title xml:lang="en"><![CDATA[Factors associated with the appearance of subclinical atherosclerosis in systemic lupus erythematosus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Muñiz]]></surname>
<given-names><![CDATA[Yanileydys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dedieu Montero]]></surname>
<given-names><![CDATA[Diosmary]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pozo Abreu]]></surname>
<given-names><![CDATA[Silvia María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carrillo Reyes]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mederos Castellanos]]></surname>
<given-names><![CDATA[Ailyn]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Centro de Referencias para las Enfermedades reumáticas ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Hospital Docente Clínico Quirúrgico 10 de Octubre ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>24</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1817-59962022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1817-59962022000100004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1817-59962022000100004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El lupus eritematoso sistémico es una enfermedad inflamatoria, crónica, multisistémica, que se define por sus múltiples rasgos clínicos y por la casi invariable presencia de autoanticuerpos dirigidos contra uno o más componentes del núcleo celular.  Objetivo: Caracterizar a los pacientes con lupus eritematoso sistémico e identificar su posible relación con la aterosclerosis subclínica.  Métodos: Se realizó un estudio transversal, descriptivo, de pacientes con diagnóstico de lupus eritematoso sistémico, atendidos en el Centro de Reumatología en La Habana, durante el periodo comprendido entre octubre del 2015 a octubre del 2017. La muestra fue no probabilística y estuvo formada por 50 pacientes. Se empleó estadística descriptiva e inferencial.  Resultados:  Del total de pacientes el 54,0 % (n = 27) presentaba aterosclerosis subclínica. Los factores de riesgo tradicionales que mostraron asociación con la presencia de placa en pacientes con LES fueron la hipercolesterolemia, 70,4 % (n = 19) e hipertrigliceridemia 55,6 % (n = 15). Se observó relación entre el tiempo de evolución, presencia de daño acumulado, compromiso renal, cifras de PCR y dosis acumulada de esteroides, con la presencia de aterosclerosis subclínica.  Conclusiones:  Se constató en pacientes con LES y presencia de placa un promedio de edad mayor. Los factores de riesgo tradicionales que mostraron asociación con la presencia de placa aterosclerótica fueron hipercolesterolemia e hipertrigliceridemia. Se comprobó asociación entre el tiempo de evolución, daño acumulado, compromiso renal, cifras de PCR y dosis acumulada de esteroides, con la presencia de placa. En los pacientes del estudio el uso de cloroquina estuvo asociado a la no aparición de aterosclerosis subclínica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Systemic lupus erythematosus is an inflammatory, chronic, multisystemic disease, which is defined by its multiple clinical features and by the almost invariable presence of autoantibodies directed against one or more components of the cell nucleus.  Objective: To characterize patients with Systemic Lupus Erythematosus and to identify its possible relationship with subclinical atherosclerosis.  Methods: A descriptive cross-sectional study of patients diagnosed with Systemic Lupus Erythematosus, treated at the Rheumatology Center in Havana, was carried out during the period from October 2015 to October 2017. The sample was non-probabilistic and consisted of 50 patients. Descriptive and inferential statistics were used.  Results: Of the total number of patients, 54.0% (n=27) had subclinical atherosclerosis. The traditional risk factors that showed association with the presence of plaque in patients with SLE were hypercholesterolemia, 70.4% (n=19) and hypertriglyceridemia 55.6% (n=15). A relationship was observed between the time of evolution, the presence of accumulated damage, renal compromise, CRP figures and accumulated dose of steroids, with the presence of subclinical atherosclerosis.  Conclusions: A higher average age was found in patients with SLE and presence of plaque. The traditional risk factors that showed association with the presence of atherosclerotic plaque were hypercholesterolemia and hypertriglyceridemia. An association was found between the time of evolution, the presence of accumulated damage, renal compromise, CRP figures and the accumulated dose of steroids, with the presence of plaque. In the study patients, the use of chloroquine was associated with the absence of subclinical atherosclerosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[aterosclerosis subclínica]]></kwd>
<kwd lng="es"><![CDATA[lupus eritematoso sistémico]]></kwd>
<kwd lng="es"><![CDATA[factor de riesgo]]></kwd>
<kwd lng="en"><![CDATA[subclinical atherosclerosis]]></kwd>
<kwd lng="en"><![CDATA[systemic lupus erythematosus]]></kwd>
<kwd lng="en"><![CDATA[risk factor]]></kwd>
</kwd-group>
</article-meta>
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