<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2074-8647</journal-id>
<journal-title><![CDATA[Biotecnología Vegetal]]></journal-title>
<abbrev-journal-title><![CDATA[Biot. Veg.]]></abbrev-journal-title>
<issn>2074-8647</issn>
<publisher>
<publisher-name><![CDATA[Instituto de Biotecnología de las PlantasUniversidad Central Marta Abreu de Las Villas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2074-86472019000200127</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Optimización del medio de cultivo y las condiciones de fermentación para la producción de un biofertilizante a base de Pseudomonas fluorescens]]></article-title>
<article-title xml:lang="en"><![CDATA[Optimization of the culture medium and fermentation conditions for Pseudomonas fluorescens-based biofertilizers production]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Peñaranda]]></surname>
<given-names><![CDATA[María Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oramas García]]></surname>
<given-names><![CDATA[Julio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sotolongo Valdés]]></surname>
<given-names><![CDATA[Emilio Arcadio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda Galuzzo]]></surname>
<given-names><![CDATA[Alina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Román Tabio]]></surname>
<given-names><![CDATA[Yoandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Soto]]></surname>
<given-names><![CDATA[Alain]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Unidad de Desarrollo-Innovación del Grupo Empresarial Laboratorios Biológicos Farmacéuticos (LABIOFAM)  ]]></institution>
<addr-line><![CDATA[Boyeros La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Tecnológica de La Habana Facultad de Ingeniería Química ]]></institution>
<addr-line><![CDATA[La Habana Marianao]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Unidad Empresarial de Base VIMANG-LABIOFAM  ]]></institution>
<addr-line><![CDATA[Arroyo Naranjo La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>19</volume>
<numero>2</numero>
<fpage>127</fpage>
<lpage>138</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2074-86472019000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2074-86472019000200127&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2074-86472019000200127&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En Cuba se ha desarrollado un biofertilizante a base de una cepa de Pseudomonas fluorescens, solubilizadora de fosfatos. Ante la necesidad de estandarizar su escalado industrial este trabajo tuvo por objetivo optimizar el medio de cultivo y las condiciones de fermentación. Primero se realizaron ensayos a escala de zaranda y posteriormente en un fermentador. En cada caso se realizó una validación experimental. Para la optimización del medio de cultivo se empleó un diseño compuesto central para ajustar superficies de respuesta. Se aplicó un diseño factorial 23 con puntos estrellas equidistantes y seis repeticiones en el centro del plan considerado como cero. Se realizaron un total de 20 corridas experimentales, con tres repeticiones cada una y se determinó la ecuación de regresión. Como variable de respuesta se determinó el crecimiento celular por densidad óptica &#955; =600 nm (DO600). Para optimizar del crecimiento microbiano en función de la velocidad de agitación y el flujo de aire se empleó un fermentador de 12 litros de volumen total con 8.5 litros de volumen efectivo con un diseño factorial 22, tomando como variable de respuesta la DO600. Se comprobó que para la producción industrial de P. fluorescens y la formulación del bioproducto puede emplearse un medio de cultivo semisintético optimizado, sin melaza, que unido al empleo de una velocidad de agitación y flujo de aire óptimos permiten incrementar el contenido de biomasa bacteriana. Las nuevas condiciones permitieron reducir el tiempo de fermentación a 12 horas con respecto a las 20 a 22 horas que se empleaban en el esquema de producción. Además, se redujo el 29%, 50% y 40%, respectivamente de las fuentes de carbono, nitrógeno y fósforo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In Cuba, a biofertilizer has been developed based on a Pseudomonas fluorescens strain phosphate solubilizer. Given the need to standardize its industrial scale up, this work aimed to optimize the culture medium and the fermentation conditions. First, tests in the shaker were carried out and then in a fermenter. In each case an experimental validation was performed. For the optimization of the culture medium, a central composite design was used to adjust response surfaces. A 23 factorial design with equidistant star points and six repetitions in the center of the plan considered zero was applied. A total of 20 experimental runs were performed, with three repetitions each and the regression equation was determined. As a response variable, cell growth was determined by optical density &#955; = 600 nm (OD600). To optimize microbial growth based on agitation speed and air flow, a 12-liter total volume fermenter with 8.5 liters of effective volume with a factorial design 22 was used, taking OD600 as the response variable. It was found that for the industrial production of P. fluorescens and the formulation of the bioproduct, an optimized semisynthetic culture medium can be used, without molasses. Together with the employed of optimal agitation speed and air flow, the bacterial biomass content can be increased. The new conditions allowed reducing the fermentation time to 12 hours compared to the 20 to 22 hours used in the production scheme. In addition, 29%, 50% and 40%, respectively, of carbon, nitrogen and phosphorus sources were reduced.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[bioproducto]]></kwd>
<kwd lng="es"><![CDATA[diseño compuesto central]]></kwd>
<kwd lng="es"><![CDATA[metodología de superficie respuesta]]></kwd>
<kwd lng="en"><![CDATA[bioproduct]]></kwd>
<kwd lng="en"><![CDATA[central composite design]]></kwd>
<kwd lng="en"><![CDATA[response surface methodology]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abdel-Fattah]]></surname>
<given-names><![CDATA[YR]]></given-names>
</name>
<name>
<surname><![CDATA[Olama]]></surname>
<given-names><![CDATA[ZA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[L-asparaginase production by Pseudomonas aeruginosa in solid-state culture: evaluation and optimization of culture conditions using factorial designs]]></article-title>
<source><![CDATA[Process Biochemistry]]></source>
<year>2002</year>
<volume>38</volume>
<page-range>115-22</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abo-Zaid]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Wagih]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
<name>
<surname><![CDATA[Matar]]></surname>
<given-names><![CDATA[SM]]></given-names>
</name>
<name>
<surname><![CDATA[Ashmawy]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Hafez]]></surname>
<given-names><![CDATA[EE]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimization of pyocyanin production from Pseudomonas aeruginosa JY21 using statistical experimental designs]]></article-title>
<source><![CDATA[International Journal of ChemTech Research]]></source>
<year>2015</year>
<volume>8</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>137-48</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aguado-Santacruz]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
</person-group>
<source><![CDATA[Introducción al uso y manejo de Biofertilizantes en la agricultura]]></source>
<year>2012</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[INIFAP/SAGARPA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bach]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fosforina, ¿solo una alternativa para la fertilizacion fosfórica?]]></article-title>
<source><![CDATA[Agricultura orgánica]]></source>
<year>2002</year>
<volume>2</volume>
<page-range>31-2</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Becerra]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<source><![CDATA[Optimización de un medio de cultivo para la producción de biomasa de la cepa Pseudomonas putida UA 44 aislada del suelo bananero de Uraba-Antioquía]]></source>
<year>2007</year>
<publisher-loc><![CDATA[Medellín, Colombia ]]></publisher-loc>
<publisher-name><![CDATA[Universidad EAFIT]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bezerra]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Santelli]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
<name>
<surname><![CDATA[Oliveira]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Villar]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Escaleira]]></surname>
<given-names><![CDATA[LA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Response surface methodology (RSM) as a tool for optimization in analytical chemistry]]></article-title>
<source><![CDATA[Talanta]]></source>
<year>2008</year>
<volume>76</volume>
<page-range>965-77</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Box]]></surname>
<given-names><![CDATA[EP]]></given-names>
</name>
<name>
<surname><![CDATA[Hunter]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
<name>
<surname><![CDATA[Hunter]]></surname>
<given-names><![CDATA[WG]]></given-names>
</name>
</person-group>
<source><![CDATA[Statistics for Experimenters: Design, Innovation, and Discovery]]></source>
<year>2005</year>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[Wiley-Interscience]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chojnacka]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Innovative bio-products for agriculture]]></article-title>
<source><![CDATA[Open Chem]]></source>
<year>2015</year>
<volume>13</volume>
<page-range>932-7</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cuervo]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<source><![CDATA[Aislamiento y caracterización de Bacillus spp. como fijadores biológicos de nitrógeno y solubilizadores de fosfatos en dos muestras de biofertilizantes comerciales]]></source>
<year>2010</year>
<publisher-loc><![CDATA[Bogotá, Colombia ]]></publisher-loc>
<publisher-name><![CDATA[Pontificia Universidad Javeriana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz-Blanco]]></surname>
<given-names><![CDATA[PO]]></given-names>
</name>
<name>
<surname><![CDATA[Márquez-Reina]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Validación de los biofertilizantes Azotobacter, Rhizobium y fosforina en cuatro sistemas de cultivos en condiciones de producción]]></article-title>
<source><![CDATA[Avances]]></source>
<year>2011</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Doran]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
</person-group>
<source><![CDATA[Bioprocess engineering principles]]></source>
<year>2013</year>
<publisher-loc><![CDATA[London ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier Ltd]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dibut]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez-Viera]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Fey]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Ortega]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Un siglo de investigaciones y comercialización de biofertilizantes en Cuba]]></article-title>
<source><![CDATA[Agrotecnia de Cuba]]></source>
<year>2006</year>
<volume>30</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>79-90</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dutta]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Dutta]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
<name>
<surname><![CDATA[Banerjee]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimization of culture parameters for extracellular protease production from a newly isolated Pseudomonas sp. using response surface and artificial neural network models]]></article-title>
<source><![CDATA[Process Biochem]]></source>
<year>2004</year>
<volume>39</volume>
<page-range>2193-8</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gagreda-Cabrera]]></surname>
<given-names><![CDATA[OA]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz-Franco]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Peña-Cabriales]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Vera-Niñez]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Impacto de los biofertilizantes en la agricultura]]></article-title>
<source><![CDATA[Revista Mexicana de Ciencias Agrícolas]]></source>
<year>2012</year>
<volume>3</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1261-74</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kulkarni]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[Studies on lipase enzyme from Pseudomonas fluorescens NS2W]]></source>
<year>2002</year>
<publisher-loc><![CDATA[Maharashtra, India ]]></publisher-loc>
<publisher-name><![CDATA[University of Pune]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Miller]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of Dinitrosalicilic Acid Reagent for Determination of Reducing Sugar]]></article-title>
<source><![CDATA[Analytical Chemistry]]></source>
<year>1959</year>
<volume>31</volume>
<page-range>426-8</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Otieno]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lally]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Kiwanuka]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Lloyd]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Ryan]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Germaine]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Dowling]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Plant growth promotion induced by phosphate solubilizing endophytic Pseudomonas isolates]]></article-title>
<source><![CDATA[Frontiers in Microbiology]]></source>
<year>2015</year>
<volume>6</volume>
<page-range>745-56</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Patil]]></surname>
<given-names><![CDATA[MD]]></given-names>
</name>
<name>
<surname><![CDATA[Shinde]]></surname>
<given-names><![CDATA[KD]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Chisti]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Banerjee]]></surname>
<given-names><![CDATA[UC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Use of response surface method for maximizing the production of arginine deiminase by Pseudomonas putida]]></article-title>
<source><![CDATA[Biotechnology Reports]]></source>
<year>2016</year>
<volume>10</volume>
<page-range>29-37</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[KJ]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Rhee]]></surname>
<given-names><![CDATA[SK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Statistical optimization of medium for the production of recombinant hirudin from Saccharomyces cerevisiae using response surface methodology]]></article-title>
<source><![CDATA[Process Biochemistry]]></source>
<year>2000</year>
<volume>35</volume>
<page-range>639-47</page-range></nlm-citation>
</ref>
<ref id="B20">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scragg]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
</person-group>
<source><![CDATA[Biotecnología para los ingenieros: Sistemas biológicos en procesos tecnológicos]]></source>
<year>1997</year>
<publisher-loc><![CDATA[México ]]></publisher-loc>
<publisher-name><![CDATA[ed LIMUSA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B21">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sun]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Ramsay]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Guay]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Ramsay]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Automated feeding strategies for high-cell-density fed-batch cultivation of Pseudomonas putida KT2440]]></article-title>
<source><![CDATA[Microbiol Biotechnol]]></source>
<year>2006</year>
<volume>71</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>423-31</page-range></nlm-citation>
</ref>
<ref id="B22">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tapia]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La disponibilidad del fósforo es producto de la actividad bacteriana en el suelo en ecosistemas oligotróficos: una revisión crítica]]></article-title>
<source><![CDATA[Terra Latinoamericana]]></source>
<year>2013</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>231-42</page-range></nlm-citation>
</ref>
<ref id="B23">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tanyol]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Uslu]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Yönten]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimization of lipase production on agro-industrial residue medium by Pseudomonas fluorescens (NRLL B-2641) using response surface methodology]]></article-title>
<source><![CDATA[Biotechnol Biotechnol Equip]]></source>
<year>2015</year>
<volume>29</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>64-71</page-range></nlm-citation>
</ref>
<ref id="B24">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[van Keulen]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Siebring]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dijkhuizen]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Central Carbon Metabolic Pathways in Streptomyces]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Dyson]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Streptomyces: Molecular Biology and Biotechnology]]></source>
<year>2011</year>
<page-range>105-24</page-range><publisher-loc><![CDATA[Norfolk ]]></publisher-loc>
<publisher-name><![CDATA[Caister Academic Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B25">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wan]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Experimental design methods for fermentative hydrogen production: A review]]></article-title>
<source><![CDATA[International Journal of Hydrogen Energy]]></source>
<year>2009</year>
<volume>34</volume>
<page-range>235-44</page-range></nlm-citation>
</ref>
<ref id="B26">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiong]]></surname>
<given-names><![CDATA[ZQ]]></given-names>
</name>
<name>
<surname><![CDATA[Tu]]></surname>
<given-names><![CDATA[XR]]></given-names>
</name>
<name>
<surname><![CDATA[Tu]]></surname>
<given-names><![CDATA[GQ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Optimization of medium composition for actinomycin X2 production by Streptomyces spp. JAU4234 using response surface methodology]]></article-title>
<source><![CDATA[J Ind Microbiol Biotechnol]]></source>
<year>2008</year>
<volume>35</volume>
<numero>7</numero>
<issue>7</issue>
<page-range>729-34</page-range></nlm-citation>
</ref>
<ref id="B27">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhu]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Whelan]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Phosphorus activators contribute to legacy phosphorus availability in agricultural soils: A review]]></article-title>
<source><![CDATA[Science of the Total Environment]]></source>
<year>2018</year>
<volume>612</volume>
<page-range>522-37</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
