<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2434</journal-id>
<journal-title><![CDATA[Revista Finlay]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. Finlay]]></abbrev-journal-title>
<issn>2221-2434</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos. Centro Provincial de información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24342020000100022</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización cardiovascular en niños y adolescentes con anemia drepanocítica]]></article-title>
<article-title xml:lang="en"><![CDATA[Cardiovascular Characterization of Children and Adolescents with Sickle Cell Anemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vales,]]></surname>
<given-names><![CDATA[Nancy González]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Graña,]]></surname>
<given-names><![CDATA[Ximena Laura]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morejón,]]></surname>
<given-names><![CDATA[Lucía Díaz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estrada,]]></surname>
<given-names><![CDATA[Tamara Sánchez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jorge,]]></surname>
<given-names><![CDATA[Belkis Rodríguez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Caride.]]></surname>
<given-names><![CDATA[Ifraín Machín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto.  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto.  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto.  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af6">
<institution><![CDATA[,Hospital Pediátrico Universitario Paquito González Cueto  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>10</volume>
<numero>1</numero>
<fpage>22</fpage>
<lpage>32</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24342020000100022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24342020000100022&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24342020000100022&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento la anemia drepanocítica es una anemia hemolítica crónica severa con alto índice de morbimortalidad. Es bien tolerada por el sistema cardiovascular durante largo tiempo, pero con el decursar de los años se afecta la función cardíaca.  Objetivo determinar las alteraciones cardiovasculares en pacientes con drepanocitosis. Métodos: se realizó un estudio descriptivo y de corte transversal en las consultas de hematología y cardiología del Hospital Pediátrico Universitario Paquito González Cueto de Cienfuegos en el período comprendido entre el 1ro de julio del 2011 al 31 de julio del 2012. Las variables analizadas fueron: edad, sexo, hemoglobina basal media, estado nutricional, interrogatorio y examen físico, presión arterial, electrocardiograma, radiografía de tórax a distancia de tele, ecocardiograma.  Resultados:  el grupo etáreo predominante fue el de 7 a 10 años, con un 52,4 %, sobresaliendo el sexo masculino, la hemoglobina basal entre 80 y 90,9g/l representó un 57 %. El 85,7 % presentaron hepatomegalia y en el 71,4 % hubo danza arterial, 57,1 % manifestaron soplo sistólico y el 23,8 % latido supraesternal. El 100 % de los casos presentaron electrocardiograma y ecocardiograma normales. La correlación entre la hemoglobina basal y el estado nutricional demostró una prevalencia del 66,7 % para los niños eutróficos, predominando la SB talasemia con 80 %. El 57 % presentó repercusión cardiovascular principalmente el grupo de 7 a 10 años con 63,6 %.  Conclusiones: se lograron identificar alteraciones cardiovasculares a través de la clínica, encontrándose repercusión ligera, corroborada solo por el telecardiograma, donde se identificó la presencia de cardiomegalia grado l-ll.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Foundation:  sickle cell anemia is a severe chronic hemolytic anemia with a high morbidity and mortality rate. It is well tolerated by the cardiovascular system for a long time, but as years pass, cardiac function is affected.  Objective:  to determine the cardiovascular disturbances in patients with sickle cell disease.  Methods:  a descriptive and cross-sectional study was conducted in the hematology and cardiology consultations of the Paquito González Cueto de Cienfuegos University Pediatric Hospital from July 1, 2011 to July 31, 2012. The variables analyzed were: age, sex, mean baseline hemoglobin, nutritional status, interrogation and physical examination, blood pressure, electrocardiogram, remote chest radiography, echocardiogram.  Results:  the predominant age group was 7 to 10 years old, with 52.4 %, with a predominance male sex standing out, baseline hemoglobin between 80 and 90.9g / l represented 57 %. 85.7 % had hepatomegaly and in 71.4 % there was arterial dance, 57.1 % showed systolic murmur and 23.8 % suprasternal beat. 100 % of the cases presented normal electrocardiogram and echocardiogram. The correlation between baseline hemoglobin and nutritional status showed a prevalence of 66.7 % for eutrophic children, with SB thalassemia predominating with 80 %. 57 % presented cardiovascular repercussion mainly the group of 7 to 10 years with 63.6 %.  Conclusions:  it was possible to identify cardiovascular disturbances through clinic features and a slight impact was observed, confirmed only by the telecardiogram, where the presence of grade l-ll cardiomegaly was identified.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[niños]]></kwd>
<kwd lng="es"><![CDATA[adolescentes]]></kwd>
<kwd lng="es"><![CDATA[anemia]]></kwd>
<kwd lng="es"><![CDATA[sistema cardiovascular]]></kwd>
<kwd lng="en"><![CDATA[children]]></kwd>
<kwd lng="en"><![CDATA[adolescent]]></kwd>
<kwd lng="en"><![CDATA[anemia]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular system]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<collab>New Englans Pediatric Sickle Cell Consortium.</collab>
<source><![CDATA[La anemia falciforme en bebés y niños pequeños]]></source>
<year>2017</year>
<publisher-loc><![CDATA[New England ]]></publisher-loc>
<publisher-name><![CDATA[NPSCC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Braunstein]]></surname>
<given-names><![CDATA[E.]]></given-names>
</name>
</person-group>
<source><![CDATA[Anemia de células falciformes]]></source>
<year>2017</year>
<publisher-loc><![CDATA[E.U ]]></publisher-loc>
<publisher-name><![CDATA[Merck Sharp]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Svarch]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Ballester]]></surname>
<given-names><![CDATA[JM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La drepanocitosis en Cuba]]></article-title>
<source><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></source>
<year>2004</year>
<volume>20</volume>
<numero>2</numero>
<issue>2</issue>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Svarch]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Marcheco]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Machín]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Menéndez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Nordet]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Arencibia]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[La drepanocitosis en Cuba. Estudio en niños.]]></article-title>
<source><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></source>
<year>2011</year>
<volume>27</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Arango]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Cedré]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comportamiento de las alteraciones renales en pacientes pediátricos con drepanocitosis.]]></article-title>
<source><![CDATA[Acta Médica del Centro]]></source>
<year>2016</year>
<volume>11</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zivot]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Apollonsky]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Gracely]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Raybagkar]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Body Mass Index and the Association With Vaso occlusive Crises in Pediatric Sickle Cell Disease]]></article-title>
<source><![CDATA[J Pediatr Hematol Oncol]]></source>
<year>2017</year>
<volume>39</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>314-7</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rojas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Calderón]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Vidal]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Arroyo]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Torres]]></surname>
<given-names><![CDATA[LM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Crisis drepanocítica y tratamiento del dolor.]]></article-title>
<source><![CDATA[Rev Soc Esp Dolor]]></source>
<year>2015</year>
<volume>22</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ayala]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
<name>
<surname><![CDATA[David]]></surname>
<given-names><![CDATA[GJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Anemia de células falciformes: una revisión.]]></article-title>
<source><![CDATA[Salud Uninorte]]></source>
<year>2016</year>
<volume>32</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Jitraruch]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Autoimmune Liver Disease in Children with Sickle Cell Disease]]></article-title>
<source><![CDATA[J Pediatr]]></source>
<year>2017</year>
<numero>1</numero>
<issue>1</issue>
<page-range>189:79-85</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Aloni]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acute Crises and Complications of Sickle Cell Anemia Among Patients Attending a Pediatric Tertiary Unit in Kinshasa, Democratic Republic Of Congo]]></article-title>
<source><![CDATA[Hematol Rep]]></source>
<year>2017</year>
<volume>9</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>6952</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Woods]]></surname>
<given-names><![CDATA[GM]]></given-names>
</name>
<name>
<surname><![CDATA[Sharma]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Creary]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Venous Thromboembolism in Children with Sickle Cell Disease A Retrospective Cohort Study]]></article-title>
<collab>O&amp;aposBrien S.Stanek J.Hor K</collab>
<source><![CDATA[J Pediatr]]></source>
<year>2018</year>
<volume>197</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>30165-3</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="book">
<collab>Mayo Clinic</collab>
<source><![CDATA[Sickle cell Anemia]]></source>
<year>2016</year>
<publisher-loc><![CDATA[Minnesota ]]></publisher-loc>
<publisher-name><![CDATA[MC]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Caldas]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
<name>
<surname><![CDATA[Meira]]></surname>
<given-names><![CDATA[ZA]]></given-names>
</name>
<name>
<surname><![CDATA[Barbosa]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of 107 patients with sickle cell anemia through tissue Doppler and myocardial performance index]]></article-title>
<source><![CDATA[J Am Soc Echocardiogr]]></source>
<year>2008</year>
<volume>21</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1163-7</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zilberman]]></surname>
<given-names><![CDATA[MV]]></given-names>
</name>
<name>
<surname><![CDATA[Du]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Das]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Sarnaik]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of left Ventricular diastolic function in pediatric sickle cell disease patients]]></article-title>
<source><![CDATA[Am J Hematol]]></source>
<year>2007</year>
<volume>82</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>433-8</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Batra]]></surname>
<given-names><![CDATA[AS]]></given-names>
</name>
<name>
<surname><![CDATA[Acherman]]></surname>
<given-names><![CDATA[RJ]]></given-names>
</name>
<name>
<surname><![CDATA[Wong]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Chan]]></surname>
<given-names><![CDATA[LS]]></given-names>
</name>
<name>
<surname><![CDATA[Ramicone]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Abnormalities in Children With Sickle Cell Anemia]]></article-title>
<source><![CDATA[J Am Journal Hematol]]></source>
<year>2002</year>
<volume>70</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>306-12</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kato]]></surname>
<given-names><![CDATA[GJ]]></given-names>
</name>
<name>
<surname><![CDATA[Onyekwere]]></surname>
<given-names><![CDATA[OC]]></given-names>
</name>
<name>
<surname><![CDATA[Gladwin]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pulmonary hypertension in sickle cell disease Relevance to Children]]></article-title>
<source><![CDATA[Pediatr Hematol Oncol]]></source>
<year>2007</year>
<volume>24</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>159-70</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Barsaoui]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Ben Ameur]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Maherzi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Oueslati]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bousnina]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cardiac manifestations of sickle cell disease]]></article-title>
<source><![CDATA[Med Trop (Mars)]]></source>
<year>1992</year>
<volume>52</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>187-90</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Klinefelter]]></surname>
<given-names><![CDATA[HF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The heart in sickle cell anaemia]]></article-title>
<source><![CDATA[Am J Med Sci]]></source>
<year>2002</year>
<volume>203</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>34-51</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Balfour]]></surname>
<given-names><![CDATA[IC]]></given-names>
</name>
<name>
<surname><![CDATA[Covitz]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Davis]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Rao]]></surname>
<given-names><![CDATA[PS]]></given-names>
</name>
<name>
<surname><![CDATA[Strong]]></surname>
<given-names><![CDATA[WB]]></given-names>
</name>
<name>
<surname><![CDATA[Alpert]]></surname>
<given-names><![CDATA[BS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cardiac size and function in children with sickle cell anemia]]></article-title>
<source><![CDATA[Am Heart J]]></source>
<year>1984</year>
<volume>108</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>345-50</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
