<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2442</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Químicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Quím.]]></abbrev-journal-title>
<issn>2221-2442</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24422021000100060</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Purificación de la mezcla de los isómeros 3´ ,4´ y 4´ ,6´ isopropilidén de la lactosa]]></article-title>
<article-title xml:lang="en"><![CDATA[Purification of the mixture of the isomers 3´, 4´ and 4´, 6´ lactose isopropyliden]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González León]]></surname>
<given-names><![CDATA[Denia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesa Ramos]]></surname>
<given-names><![CDATA[Liber]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vázquez Madera]]></surname>
<given-names><![CDATA[Idalis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdespino Tesillo]]></surname>
<given-names><![CDATA[Yasmani]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Edreira]]></surname>
<given-names><![CDATA[Mercedes]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruíz García]]></surname>
<given-names><![CDATA[José]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Tecnológica de La Habana José Antonio Echevarría Facultad de Ingeniería Química ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Finlay de Vacunas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>52</volume>
<numero>1</numero>
<fpage>60</fpage>
<lpage>71</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24422021000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24422021000100060&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24422021000100060&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En la síntesis de aceptores de lactosa que serán utilizados para formar parte de oligisacaridos y glicoconjugados, es necesario la protección de las posiciones 3´,4´ de la lactosa con grupo isopropilidén. En la reacción química de protección de estas posiciones se obtienen varios productos colaterales que son necesarios separar del isómero de interés. Se ha reportado la realización de dos purificaciones en columna cromatográfica y una cristalización final. El presente trabajo propone la sustitución de la primera purificación cromatográfica por dos extracciones: una líquido-líquido y una líquido-sólido. Además, se realizó un diseño de experimento para determinar las mejores condiciones en las dos extracciones. En la extracción líquido-líquido se utilizó como disolvente diclorometano con una relación entre el disolvente orgánico y la fase acuosa en el nivel + 1, una velocidad de agitación en el nivel +1 y se repitió la operación ocho veces. En la extracción líquido-sólido se utilizó como disolvente acetona con una relación líquido-sólido en el nivel +1, una velocidad de agitación en el nivel -1 y la operación se repitió 12 veces. Se comparó el método de purificación de la literatura y la propuesta realizada y en ambos se obtienen cantidades similares de la mezcla de los isómeros 3´,4´ y 4´,6´ isopropilidén de lactosa, pero en la propuesta se alcanza en un tiempo menor y con una notable reducción del consumo de reactivos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In the synthesis of lactose acceptor that will be used to take part of oligisacarides and glicoconjugate it is necessary the protection of the 3´,4´ lactose positions with the isopropylidene group. In the chemical reaction, several collateral products are also obtained that must be separated from the isomer of interest. Two chromatographic column purifications and one final crystallization have been reported. In this work, the first chromatographic purification is replaced by two extractions: one liquid-liquid and one solid-liquid. Besides, an experimental design was also made to identify the best operation conditions for the extractions. In the liquid- liquid extraction dichloromethane was used with a liquid-liquid ratio at level +1 and a stirring speed at level +1. The operation was repeated eight times. In the solid-liquid extraction, acetone was used with a liquid-solid ratio at level +1 and a stirring speed at level -1. The operation was repeated 12 times. The purification method described in the literature and the method proposed in the present work were compared, and both obtained similar amounts of the mixture of the 3 ', 4' and 4 ', 6' isopropylidene lactose isomers. Following the proposed method, the results are obtained in a shorter time and with a notable reduction in the consumption of reagents.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[extracción líquido-sólido]]></kwd>
<kwd lng="es"><![CDATA[3´,4´-isopropilidén and de lactosa]]></kwd>
<kwd lng="es"><![CDATA[extracción líquido-líquido]]></kwd>
<kwd lng="en"><![CDATA[liquid-solid extraction]]></kwd>
<kwd lng="en"><![CDATA[3´]]></kwd>
<kwd lng="en"><![CDATA[4´-isopropylidene and lactose]]></kwd>
<kwd lng="en"><![CDATA[liquid-liquid extraction]]></kwd>
</kwd-group>
</article-meta>
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