<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2442</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Químicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Quím.]]></abbrev-journal-title>
<issn>2221-2442</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24422023000100044</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[ESTUDIO DE ESTABILIDAD PRELIMINAR DE DOS CREMAS PARA EL TRATAMIENTO DEL ACNÉ]]></article-title>
<article-title xml:lang="en"><![CDATA[PRELIMINARY STABILITY STUDY OF TWO CREAMS FOR ACNE TREATMENT]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerra Collazo]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hakim Rodríguez]]></surname>
<given-names><![CDATA[Dania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cordero Hernández]]></surname>
<given-names><![CDATA[Manuel Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cima Sotolongo]]></surname>
<given-names><![CDATA[Gonzalo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iglesias Torriente]]></surname>
<given-names><![CDATA[Shesie]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández García]]></surname>
<given-names><![CDATA[Lidia Asela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>54</volume>
<fpage>44</fpage>
<lpage>51</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24422023000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24422023000100044&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24422023000100044&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Entre los factores actualmente identificados en la aparición del acné se encuentra la proliferación bacteriana de Cutibacterium acnes debida a la seborrea y la hiperqueratosis. Los tratamientos tópicos para el acné son estrictamente necesarios y van desde antibióticos hasta ácido salicílico dependiendo siempre del tipo de acné que se desee tratar. Los mecanismos de acción principales de los productos de uso tópico para esta enfermedad van encaminados a eliminar el exceso de bacterias de la piel y reducir el proceso de enrojecimiento y la inflamación. Para el tratamiento de esta enfermedad se desarrollaron dos cremas utilizando dos concentraciones de OLEOZON® tópico como ingrediente farmacéutico activo, con polisorbato 80 como agente emulgente y otros excipientes. Se realizó un estudio de estabilidad durante seis meses, el cual mostró su comportamiento a las dos temperaturas de almacenamiento (2-8&#730;C y 30&#730;C) desde el punto de vista organoléptico, físico-químico y microbiológico. Este último demostró una marcada actividad antimicrobiana y ausencia de microrganismos en las muestras durante los seis meses de estudio. Las propiedades organolépticas mostraron mejores resultados a bajas temperaturas de almacenamiento, ya que se mantuvieron uniformes en cuanto a color, olor y textura; de igual forma la evaluación físico-química corroboró un mejor comportamiento para las cremas almacenadas a bajas temperaturas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Among the factors currently identified in the appearance of acne is the bacterial proliferation of Cutibacterium acnes due to seborrhea and hyperkeratosis. Topical acne treatments are strictly necessary and range from antibiotics to salicylic acid depending on the type of acne to be treated. The main mechanisms of action of topical products for this disease are aimed at eliminating excess bacteria from the skin and reducing the process of redness and inflammation. For the treatment of this disease, two creams were developed using two concentrations of topical OLEOZON® as active pharmaceutical ingredient, with polysorbate 80 as emulsifying agent and other excipients. A stability study was performed for six months, which showed its behavior at the two storage temperatures (2-8&#730;C and 30&#730;C) from the organoleptic, physicochemical and microbiological point of view, the latter showed a marked antimicrobial activity and absence of microorganisms in the samples during the six months of study. The organoleptic properties showed better results at low storage temperatures, since they remained uniform in terms of color, odor and texture; likewise, the physicochemical evaluation corroborated a better performance for the creams stored at low temperatures.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[crema]]></kwd>
<kwd lng="es"><![CDATA[acné]]></kwd>
<kwd lng="es"><![CDATA[estabilidad]]></kwd>
<kwd lng="es"><![CDATA[formulación]]></kwd>
<kwd lng="es"><![CDATA[aceite ozonizado]]></kwd>
<kwd lng="en"><![CDATA[cream]]></kwd>
<kwd lng="en"><![CDATA[acne]]></kwd>
<kwd lng="en"><![CDATA[stability]]></kwd>
<kwd lng="en"><![CDATA[formulation]]></kwd>
<kwd lng="en"><![CDATA[ozonized oil]]></kwd>
</kwd-group>
</article-meta>
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