<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502020000300164</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluaciones Conductuales en un modelo de bebedor social en ratas Wistar]]></article-title>
<article-title xml:lang="en"><![CDATA[Behavioral assessments in a social drinker model in Wistar rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Duquesne Chávez]]></surname>
<given-names><![CDATA[Alicia de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Soto]]></surname>
<given-names><![CDATA[María Teresa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto de Farmacia y Alimentos  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>51</volume>
<numero>3</numero>
<fpage>164</fpage>
<lpage>172</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502020000300164&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502020000300164&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502020000300164&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En los últimos años se ha señalado la importancia del estudio de las características inherentes a las etapas que conllevan al alcoholismo. La escasez de estos estudios es un factor controvertido ya que el desarrollo de modelos que abarquen la relevancia de estas etapas podrían ser sumamente importantes en la búsqueda del ¨punto crítico¨ en que se puede identificar el momento en que un individuo en etapas avanzadas de la adicción pueda desarrollar alcoholismo, o en el que un bebedor social se convierta en un bebedor de riesgo,meramente basándose en la particularidadde los cambios conductuales que presente. El presente trabajo tiene como objetivo evaluar las afectaciones conductuales relacionadas con el estado neuronal en un modelo de bebedor social en ratas Wistar, las cuales fueron distribuidas en 2 grupos Control (Agua) y grupo Etanol que fue administrado por el método caja-hogar &#8220;ad libitum&#8221; a diferentes concentraciones (5%, 10%, 15% y 20%.) 2 veces por semana durante siete semanas. Fueron aplicados el Laberinto Acuático de Morris, el Laberinto Elevado en Cruz y el Test de Irwin. El modelo desarrollado mimetiza el comportamiento de bebedor social en humanos en cuanto al consumo de etanol. Se concluyó que existieron afectaciones relacionadas con el estado de ansiedad en el Laberinto Elevado en Cruz además de una afectación incipiente de la transmisión dopaminérgicamediante el test de Irwin y el consumo de etanol no existiendo afectación de la memoria medida en el laberinto Acuático de Morris. Estos resultados señalan el incipiente desequilibrio neuronal que caracteriza al bebedor social.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  In recent years the importance of the study of the characteristics inherent to the stages that lead to alcoholism has been pointed out. The scarcity of these studies is a controversial factor since the development of models that encompass the relevance of these stages could be extremely important in the search for the &#8220;critical point&#8221; in which the moment in which an individual in advanced stages of the process can be identified addiction can develop alcoholism, or in which a social drinker becomes a risky drinker, merely based on the particularity of the behavioral changes that he presents. The present work has as objective to evaluate the behavioral affectations related to the neuronal state in a model of social drinker in Wistar rats which were distributed in 2 Control groups (Water) and Ethanol group that was administered by the cash-home method &#8220;ad libitum&#8221;At different concentrations (5%, 10%, 15% and 20%.) 2 times a week for seven weeks. The Morris Water Labyrinth, the Elevated Cross Labyrinth and the Irwin Test were applied. The model developed mimics the behavior of social drinkers in humans in terms of ethanol consumption. It was concluded that there were affectations related to the state of anxiety in the Elevated Labyrinth in Cruz in addition to an incipient affectation of the dopaminergic transmission by means of the Irwin test and the consumption of ethanol, there being no affectation of the memory measured in the Aquatic labyrinth of Morris. These results indicate the incipient neuronal imbalance that characterizes the social drinker.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[etanol]]></kwd>
<kwd lng="es"><![CDATA[bebedor social]]></kwd>
<kwd lng="es"><![CDATA[test conductuales]]></kwd>
<kwd lng="en"><![CDATA[ethanol]]></kwd>
<kwd lng="en"><![CDATA[social drinker]]></kwd>
<kwd lng="en"><![CDATA[behavioral test]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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