<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502021000200129</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Toxicología especial de la sustancia lipídica del fruto de Acrocomia crispa (D-005) en ratas Sprague Dawley. Morfología de la cabeza del espermatozoide]]></article-title>
<article-title xml:lang="en"><![CDATA[Special toxicology of lipid substance of fruit of Acrocomia crispa (D-005) in Sprague Dawley rats. Sperm head morphology]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez Martínez]]></surname>
<given-names><![CDATA[Ariadne]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gámez Menéndez]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meneau Hernández]]></surname>
<given-names><![CDATA[Rosa Ibis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Nodal Flores]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bucarano Lliteras]]></surname>
<given-names><![CDATA[Isury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Goicochea Carrero]]></surname>
<given-names><![CDATA[Edy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas Centro de Productos Naturales Grupo de Toxicología]]></institution>
<addr-line><![CDATA[Playa Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>52</volume>
<numero>2</numero>
<fpage>129</fpage>
<lpage>136</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502021000200129&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502021000200129&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502021000200129&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El D-005, sustancia lipídica del fruto de Acrocomia crispa (palma corojo), contiene una mezcla de ácidos grasos, principalmente láurico, oleico, mirístico y palmítico y ha mostrado efectos antiinflamatorios y antioxidantes en roedores. El objetivo de este trabajo fue determinar si el D-005 induce cambios en la frecuencia de aparición de formas anómalas en la cabeza del espermatozoide y/o provoca alteraciones en la concentración de espermatozoides. Se usaron ratas Sprague Dawley machos, provenientes de un estudio de toxicidad subcrónica (90 días de tratamiento), distribuidos aleatoriamente en cuatro grupos experimentales de ocho animales cada uno: un control tratado solo con el vehículo y tres administrados con D-005 (200, 500 y 1000 mg/kg). A las 24 horas de la última administración, a cada animal se le realizó la necropsia y se extrajo el epidídimo derecho para obtener las muestras. Se calculó la concentración de espermatozoides y para el análisis de la morfología de la cabeza del espermatozoide, se siguió el criterio de clasificación basado en cabezas normales y anormales que incluye amorfas, banana, sin gancho y dos colas. No ocurrieron muertes ni se detectaron signos de toxicidad. La concentración de espermatozoides de los animales tratados con D-005 fue estadísticamente similar a la del grupo control. Los promedios de espermatozoides normales, anormales totales y de diferentes formas anómalas en los grupos tratados fueron similares a los del grupo control, indicando la inocuidad genotóxica del D-005 sobre las células germinales masculinas. El tratamiento oral con D-005 (200, 500 y 1000 mg/kg) durante el período de espermatogénesis no redujo el número total de espermatozoides ni aumentó la frecuencia de formas anómalas, por lo cual dicha sustancia en estudio no presenta potencial citotóxico ni genotóxico sobre las células germinales masculinas de ratas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT D-005, lipid substance from the fruit of Acrocomia crispa (corojo palm), contains a mixture of fatty acids, mainly lauric, oleic, myristic and palmitic and has shown anti-inflammatory and antioxidant effects in rodents. The objective of this work was to determine if D-005 induces changes in the frequency of appearance of abnormal forms in the sperm head and/or causes alterations in the sperm concentration. Male Sprague Dawley rats from an oral subchronic toxicity study (90 days of treatment) were used, randomly distributed into four experimental groups of eight animals each: a control treated only with the vehicle and three administered with D- 005 (200, 500 and 1000 mg/kg). Twenty-four hours after the last administration, each animal was necropsied and the right epididymis was extracted to obtain the samples. The sperm concentration was calculated. For the analysis of the morphology of the sperm head, the classification criterion was followed based on normal and abnormal heads that includes amorphous, banana, without hook and two tails. No deaths occurred and no signs of toxicity were detected. The sperm concentration of the animals treated with D-005 were statistically similar to those of the control group. The averages of normal, total abnormal and different abnormal sperm in the treated groups were similar to those of the control group, indicating the genotoxic safety of D-005 on male germ cells. Oral treatment with D-005 (200, 500 and 1000 mg/kg) during the period of spermatogenesis did not reduce the total number of sperm or increase the frequency of abnormal forms, therefore, this substance under study does not have cytotoxic neither genotoxic potential on male germ cells of rats.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácidos grasos]]></kwd>
<kwd lng="es"><![CDATA[cabeza del espermatozoide]]></kwd>
<kwd lng="es"><![CDATA[morfología]]></kwd>
<kwd lng="es"><![CDATA[ratas]]></kwd>
<kwd lng="es"><![CDATA[toxicología]]></kwd>
<kwd lng="en"><![CDATA[fatty acids]]></kwd>
<kwd lng="en"><![CDATA[sperm head]]></kwd>
<kwd lng="en"><![CDATA[morphology]]></kwd>
<kwd lng="en"><![CDATA[rats]]></kwd>
<kwd lng="en"><![CDATA[toxicology]]></kwd>
</kwd-group>
</article-meta>
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