<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502023000100158</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[MICROPARTÍCULAS DE POLICAPROLACTONA EN TERMOGEL DE QUITOSANA/PLURONIC PARA LA LIBERACIÓN DE DEXAMETASONA]]></article-title>
<article-title xml:lang="en"><![CDATA[POLYCAPROLACTONE MICROPARTICLES IN CHITOSAN/PLURONIC THERMOGEL FOR DEXAMETHASONE DELIVERY]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Tomás Oviedo]]></surname>
<given-names><![CDATA[Miriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Couce]]></surname>
<given-names><![CDATA[Jomarien]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fuentes Estévez]]></surname>
<given-names><![CDATA[Gastón]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amirall La Serna]]></surname>
<given-names><![CDATA[Amisel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Ricondo]]></surname>
<given-names><![CDATA[Luis Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,BioCubaFarma Empresa Laboratorios Aica Unidad I+D]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de la Habana Centro de Biomateriales ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Leiden Centro Médico ]]></institution>
<addr-line><![CDATA[ Leiden]]></addr-line>
<country>Países Bajos</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>54</volume>
<fpage>158</fpage>
<lpage>171</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502023000100158&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502023000100158&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502023000100158&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La terapia localizada mediante inyección intraarticular se utiliza en las últimas décadas para el tratamiento de la osteoartritis, siendo necesario aplicarla frecuentemente para lograr un efecto antinflamatorio adecuado, lo que provoca molestias físicas y en ocasiones daños psicológicos en los pacientes. Una posible solución a esta problemática es el empleo de un sistema inyectable de liberación controlada que permita reducir la frecuencia de aplicación. El objetivo de este trabajo es desarrollar un sistema basado en partículas de policaprolactona cargadas con dexametasona dispersas en un hidrogel termosensible de quitosana/Pluronic® F-127. Las micropartículas fueron obtenidas mediante la técnica de doble emulsión/ evaporación del disolvente. El hidrogel se preparó a partir de una mezcla física de quitosana y Pluronic® F127 a una concentración de 1 y 25 % respectivamente. El sistema fue preparado dispersando 50 mg de las micropartículas en 2 mL del hidrogel líquido. Se caracterizaron las muestras mediante espectroscopía infrarroja (FTIR, en inglés) y microscopía electrónica de barrido (MEB), se evaluó su citocompatibilidad empleando la línea celular C-28 de condrocitos humanos a través del ensayo de 3- (4,5-dimetiltiazol-2-il) -5- (3-carboximetoxifenil) -2- (4-sulfofenil) -2H-tetrazolio (MTS) y se llevó a cabo un estudio de liberación de dexametasona en disolución tampón fosfato salina (PBS) durante 7 días. Las micropartículas obtenidas presentaron forma esférica definida y un tamaño entre 4-14 µm. La caracterización mediante espectroscopía infrarroja evidenció que no existen interacciones químicas entre los polímeros que conforman el hidrogel. Todas las muestras analizadas demostraron ser citocompatibles con la línea celular C-28. El estudio de liberación demostró que el sistema presenta un mayor control de la liberación de dexametasona con respecto a las micropartículas lo que evidencia ser una opción prometedora para el desarrollo de sistemas de administración intraarticular en el tratamiento farmacológico de la osteoartritis.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The use of local intra-articular injection therapy for the treatment of osteoarthritis has experienced an increase in recent decades. With this treatment, frequent injections are necessary to obtain an adequate anti-inflammatory effect, which implies greater inconveniences for the patients. An alternative could be use injectable controlled release systems that allow to reduce the frequency of application. The aim of this research is to develop a system based on dexamethasone-loaded polycaprolactone particles dispersed in a thermosensitive chitosan/Pluronic® F-127 hydrogel. The microparticles were obtained by the double emulsion / solvent evaporation technique. The hydrogel is prepared from a physical mixture of chitosan and Pluronic® F127. The microparticle / hydrogel system was prepared by dispersing 50 mg of particles in 2 mL of the liquid hydrogel. The samples were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The cytocompatibility of the samples was evaluated using the C-28 cell line of human chondrocytes by the 3- (4,5-dimethylthiazol-2-yl) -5- (3-carboxymethoxyphenyl) -2- (4-sulfophenyl) -2H-tetrazolium (MTS) assay and a study of dexamethasone release in phosphate buffered saline solution (PBS) was carried out for 7 days. The particles have a defined spherical shape and a size between 4-14 µm. The characterization by Fourier transform infrared spectroscopy showed that there are no chemical interactions between chitosan and Pluronic® F127 in the hydrogel. All the analyzed samples were cytocompatible with the C-28 cell line. The release study showed that the system has greater control over dexamethasone release. The system proves to be a promising option as an intra-articular administration system in the pharmacological treatment of osteoarthritis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[micropartículas]]></kwd>
<kwd lng="es"><![CDATA[hidrogeles]]></kwd>
<kwd lng="es"><![CDATA[policaprolactona]]></kwd>
<kwd lng="es"><![CDATA[quitosana]]></kwd>
<kwd lng="es"><![CDATA[pluronic]]></kwd>
<kwd lng="es"><![CDATA[dexametasona]]></kwd>
<kwd lng="en"><![CDATA[microparticles]]></kwd>
<kwd lng="en"><![CDATA[hydrogels]]></kwd>
<kwd lng="en"><![CDATA[polycaprolactone]]></kwd>
<kwd lng="en"><![CDATA[chitosan]]></kwd>
<kwd lng="en"><![CDATA[pluronic]]></kwd>
<kwd lng="en"><![CDATA[dexamethasone]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ahsan]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Thomas]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Reddy]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Sooraparaju]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Asthana]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Bhatnagar]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitosan as biomaterial in drug delivery and tissue engineering]]></article-title>
<source><![CDATA[International Journal of Biological Macromolecules]]></source>
<year>2018</year>
<volume>110</volume>
<page-range>97-109</page-range></nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ali]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ahmed]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A review on chitosan and its nanocomposites in drug delivery]]></article-title>
<source><![CDATA[International Journal of Biological Macromolecules]]></source>
<year>2018</year>
<volume>109</volume>
<page-range>273-86</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ho]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Choi]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Kang]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Recent advances in intra-articular drug delivery systems to extend drug retention in joint]]></article-title>
<source><![CDATA[Journal of Pharmaceutical Investigation]]></source>
<year>2019</year>
<volume>49</volume>
<page-range>9-15</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arunkumar]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Indulekha]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Vijayalakshmi]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Srivastava]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis]]></article-title>
<source><![CDATA[Materials Science and Engineering: C]]></source>
<year>2016</year>
<volume>61</volume>
<page-range>534-44</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bodratti]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Alexandridis]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Formulation of poloxamers for drug delivery]]></article-title>
<source><![CDATA[Journal of functional biomaterials]]></source>
<year>2018</year>
<volume>9</volume>
<page-range>11</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Chen]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration]]></article-title>
<source><![CDATA[Journal of Controlled Release]]></source>
<year>2012</year>
<volume>162</volume>
<page-range>628-35</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fattahpour]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Shamanian]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Tavakoli]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Fathi]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Sadeghi-aliabadi]]></surname>
<given-names><![CDATA[H.]]></given-names>
</name>
<name>
<surname><![CDATA[Sheykhi]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Fesharaki]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fattahpour]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[An injectable carboxymethyl chitosan-methylcellulose-pluronic hydrogel for the encapsulation of meloxicam loaded nanoparticles]]></article-title>
<source><![CDATA[International Journal of Biological Macromolecules]]></source>
<year>2020</year>
<volume>151</volume>
<page-range>220-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Q.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery]]></article-title>
<source><![CDATA[Annals of Biomedical Engineering]]></source>
<year>2016</year>
<volume>44</volume>
<page-range>2049-61</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Tomás]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Fuentes]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Que]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Almirall]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitosan/Pluronic F127 thermosensitive hydrogel as an injectable dexamethasone delivery carrier]]></article-title>
<source><![CDATA[Gels]]></source>
<year>2022</year>
<volume>8</volume>
<page-range>44</page-range></nlm-citation>
</ref>
<ref id="B10">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gegel]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Shipovskaya]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Belyaeva]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Khaptsev]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Radionov]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Kharlamov]]></surname>
<given-names><![CDATA[V.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermosensitive Chitosan-Containing Hydrogels: Their Formation, Properties, Antibacterial Activity, and Veterinary Usage]]></article-title>
<source><![CDATA[Gels]]></source>
<year>2022</year>
<volume>8</volume>
<page-range>93</page-range></nlm-citation>
</ref>
<ref id="B11">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gerwin]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Hops]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Lucke]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intraarticular Drug Delivery in Osteoarthritis]]></article-title>
<source><![CDATA[Advanced drug delivery reviews]]></source>
<year>2006</year>
<volume>58</volume>
<page-range>226-42</page-range></nlm-citation>
</ref>
<ref id="B12">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hashemnejad]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
<name>
<surname><![CDATA[Badruddoza]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Zarket]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Castaneda]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Doyle]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Thermoresponsive nanoemulsion-based gel synthesized through a low-energy process]]></article-title>
<source><![CDATA[Nat. Commun]]></source>
<year>2019</year>
<volume>10</volume>
<page-range>2749</page-range></nlm-citation>
</ref>
<ref id="B13">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Heard]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
<name>
<surname><![CDATA[Barton]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
<name>
<surname><![CDATA[Chung]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Achari]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Shrive]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Frank]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Single intra&#8208;articular dexamethasone injection immediately post&#8208;surgery in a rabbit model mitigates early inflammatory responses and post&#8208;traumatic osteoarthritis&#8208;like alterations]]></article-title>
<source><![CDATA[Journal of Orthopaedic Research]]></source>
<year>2015</year>
<volume>33</volume>
<page-range>1826-34</page-range></nlm-citation>
</ref>
<ref id="B14">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Iolascon]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Gimigliano]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Moretti]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[de Sire]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Migliore]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Brandi]]></surname>
<given-names><![CDATA[M. L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Early osteoarthritis: How to define, diagnose, and manage. A systematic review]]></article-title>
<source><![CDATA[European Geriatric Medicine]]></source>
<year>2017</year>
<volume>8</volume>
<page-range>383-96</page-range></nlm-citation>
</ref>
<ref id="B15">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martínez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Cortez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ezquerra]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Graciano]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rodriguez]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Chitosan composite films: Thermal, structural, mechanical and antifungal properties]]></article-title>
<source><![CDATA[Carbohydrate Polymers]]></source>
<year>2010</year>
<volume>82</volume>
<page-range>305-15</page-range></nlm-citation>
</ref>
<ref id="B16">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mondal]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[Griffith]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Venkatraman]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Polycaprolactone-based biomaterials for tissue engineering and drug delivery: Current scenario and challenges]]></article-title>
<source><![CDATA[International Journal of Polymeric Materials and Polymeric Biomaterials]]></source>
<year>2016</year>
<volume>65</volume>
<page-range>255-65</page-range></nlm-citation>
</ref>
<ref id="B17">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Qi]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Qin]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Qin]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[W.]]></given-names>
</name>
<name>
<surname><![CDATA[Luan]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intra-articular Administration of Chitosan Thermosensitive In Situ Hydrogels Combined With Diclofenac Sodium-Loaded Alginate Microspheres]]></article-title>
<source><![CDATA[Journal of Pharmaceutical Sciences]]></source>
<year>2016</year>
<volume>105</volume>
<page-range>122-30</page-range></nlm-citation>
</ref>
<ref id="B18">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Solis]]></surname>
<given-names><![CDATA[U.]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
<name>
<surname><![CDATA[Prada]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
<name>
<surname><![CDATA[de Armas]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Ulloa]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Calidad de vida relacionada con la salud en pacientes con osteoartritis]]></article-title>
<source><![CDATA[Revista Cubana de Reumatología]]></source>
<year>2013</year>
<volume>15</volume>
<page-range>153-9</page-range></nlm-citation>
</ref>
<ref id="B19">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[Z.]]></given-names>
</name>
<name>
<surname><![CDATA[Wei]]></surname>
<given-names><![CDATA[X.]]></given-names>
</name>
<name>
<surname><![CDATA[Gao]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Guo]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intra-articular injection of cross-linked hyaluronic acid-dexamethasone hydrogel attenuates osteoarthritis: an experimental study in a rat model of osteoarthritis]]></article-title>
<source><![CDATA[International Journal of Molecular Sciences]]></source>
<year>2016</year>
<volume>17</volume>
<page-range>411</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
