<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2221-2450</journal-id>
<journal-title><![CDATA[Revista CENIC Ciencias Biológicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. CENIC Cienc. Biol]]></abbrev-journal-title>
<issn>2221-2450</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Investigaciones Científicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2221-24502023000100260</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[DEGRADACIÓN CON OZONO DE ANTIBIOTICOS BETALACTAMICOS]]></article-title>
<article-title xml:lang="en"><![CDATA[DEGRADATION WITH OZONE OF BETA LACTAMIC ANTIBIOTICS]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bataller Venta]]></surname>
<given-names><![CDATA[Mayra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Veliz Lorenzo]]></surname>
<given-names><![CDATA[Eliet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ledea Lozano]]></surname>
<given-names><![CDATA[Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bonet Fernández]]></surname>
<given-names><![CDATA[Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva Ferrer]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Torres]]></surname>
<given-names><![CDATA[Irán]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Piloto Ferrer]]></surname>
<given-names><![CDATA[Janet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ortega Peña]]></surname>
<given-names><![CDATA[Niubis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Nacional de Investigaciones Científicas  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>54</volume>
<fpage>260</fpage>
<lpage>274</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2221-24502023000100260&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2221-24502023000100260&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2221-24502023000100260&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN En fuentes de abasto de agua y ecosistemas se ha detectado la presencia de compuestos farmacéuticos, denominados contaminantes emergentes, que constituye un riesgo potencial. Los antibióticos reciben atención dada la aparición de resistencia bacteriana. Se reconoce la eficacia de la ozonización para su degradación, pero se debate la toxicidad de los subproductos de reacción. El objetivo del estudio fue establecer las condiciones de ozonización de soluciones modelo de antibióticos betalactámicos para evaluar la degradación, actividad genotóxica y antimicrobiana de muestras ozonizadas y proponer una alternativa de tratamiento de las aguas residuales industriales. Se aplicó un diseño experimental 23 con concentración de ozono en el gas de entrada (CO3(g): 70 y 100 mg/L), pH (7 y 12) y tiempos de contacto (30 y 60 min - amoxicilina / 15 y 30 min - oxacilina). La amoxicilina se redujo más del 99% en cinco min y se observaron dos grupos de subproductos, uno se degradó a los 10 min y el otro fue persistente. La oxacilina alcanzó más del 97% de degradación en dos min y se generaron subproductos que no se degradaron por completo. Las muestras ozonizadas no presentaron actividad antimicrobiana y genotoxicidad, la DQO y AbsUV-254 disminuyeron. Esto indicó que los subproductos se degradaron parcialmente y transformaron en compuestos más oxidados e inocuos. Para el tratamiento de aguas residuales industriales se propone: CO3(g): 70 mg/L, pH: 7 con 15 y 30 min. La Empresa Farmacéutica de producción de antibióticos ha iniciado un proceso inversionista en la planta de tratamiento con la incorporación de un sistema de ozonización.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT In water supply sources and ecosystems has been detected the pharmaceutical compounds presence, called emerging contaminants. This constitutes a potential risk to the environment. Antibiotics receive attention given the emergence of bacterial resistance. The effectiveness of ozonation for its degradation is recognized, but the toxicity of the reaction by-products is debated. The objective of the study was to establish the ozonation conditions of beta-lactam antibiotic model solutions to evaluate the degradation, genotoxic and antimicrobial activity of ozonated samples and propose an alternative treatment for industrial wastewater. An experimental design 23 was applied with ozone concentration in the inlet gas (CO3(g): 70 and 100 mg/L), pH (7 and 12) and contact times (30 and 60 min - amoxicillin / 15 and 30 min - oxacillin). Amoxicillin was reduced by more than 99% in 5 min and two groups of by-products were observed, one degraded within 10 min and the other remained. Oxacillin reached more than 97% degradation in two min and by-products were generated, which were not completely degraded. The ozonated samples did not present antimicrobial activity and genotoxicity, the COD and AbsUV-254 values &#8203;&#8203;decreased. This indicated that the by-products were partially degraded and transformed into more oxidized and innocuous compounds. For the treatment of industrial wastewater are proposed: CO3(g): 70 mg/L, pH: 7 with 15 and 30 min. The Pharmaceutical Company for the production of antibiotics has started an investment process in the treatment plant with the incorporation of an ozonation system.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Contaminantes emergentes]]></kwd>
<kwd lng="es"><![CDATA[antibióticos]]></kwd>
<kwd lng="es"><![CDATA[amoxicilina]]></kwd>
<kwd lng="es"><![CDATA[oxacilina]]></kwd>
<kwd lng="es"><![CDATA[antibióticos betalactámicos]]></kwd>
<kwd lng="en"><![CDATA[Emerging contaminants]]></kwd>
<kwd lng="en"><![CDATA[antibiotics]]></kwd>
<kwd lng="en"><![CDATA[amoxicillin]]></kwd>
<kwd lng="en"><![CDATA[oxacillin]]></kwd>
<kwd lng="en"><![CDATA[ozonation]]></kwd>
<kwd lng="en"><![CDATA[beta lactam antibiotics]]></kwd>
</kwd-group>
</article-meta>
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