<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2223-4861</journal-id>
<journal-title><![CDATA[Centro Azúcar]]></journal-title>
<abbrev-journal-title><![CDATA[cen. az.]]></abbrev-journal-title>
<issn>2223-4861</issn>
<publisher>
<publisher-name><![CDATA[Editorial Feijóo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2223-48612022000100115</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[MODELOS MATEMÁTICOS EN LA CINÉTICA ENZIMÁTICA. UNA REVISIÓN]]></article-title>
<article-title xml:lang="en"><![CDATA[A REVIEW OF MATHEMATICAL MODELS IN ENZYME KINETICS]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maisincho Asqui]]></surname>
<given-names><![CDATA[Maritza Paola]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Delgado Demera]]></surname>
<given-names><![CDATA[María Hipatia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cedeño Palacios]]></surname>
<given-names><![CDATA[Carlos Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Técnica de Manabí Instituto de Posgrado ]]></institution>
<addr-line><![CDATA[Portoviejo Manabí]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Técnica de Manabí Facultad de Ciencias Veterinarias Departamento de Ciencias Veterinarias]]></institution>
<addr-line><![CDATA[Portoviejo Manabí]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Técnica de Manabí Facultad de Ciencias Matemáticas, Físicas y Químicas Departamento de Procesos Químicos]]></institution>
<addr-line><![CDATA[Portoviejo Manabí]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2022</year>
</pub-date>
<volume>49</volume>
<numero>1</numero>
<fpage>115</fpage>
<lpage>131</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2223-48612022000100115&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2223-48612022000100115&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2223-48612022000100115&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: A nivel industrial la utilización de enzimas se ha ido incrementando a medida que se han optimizado sus procesos de producción, estabilización y condiciones operativas de la mano de la minimización de los costos asociados a su uso y de la sustentabilidad ambiental. El uso de la modelación matemática ha sido un factor clave para este avance, por lo que es un área de gran interés científico.  Objetivo: Conocer el estado del arte en esta área del conocimiento, resaltando los hallazgos más exitosos y promisorios publicados recientemente.  Materiales y Métodos: Se realizó una búsqueda sistemática de publicaciones recientes de alto impacto entre el 2015 y el 2021 en bases de datos reconocidas internacionalmente, y se llevó a cabo un análisis cualitativo/comparativo de los enfoques y contribuciones de la literatura seleccionada.  Resultados y Discusión: Se evidenció que la mayoría de los modelos matemáticos desarrollados parten de la ecuación cinética de Michaelis-Menten pero las simplificaciones asumidas, las condiciones operativas evaluadas y los métodos utilizados para la resolución de estos sistemas, definen la singularidad y complejidad de cada investigación, lo que hace compleja su comparación o implementación de manera estandarizada.  Conclusiones: En todos los casos, los modelos planteados se ajustaron a resultados experimentales o se observó concordancia al utilizar diferentes métodos de resolución matemática, lo que puede aportar valiosa información en la mejora de procesos y en el diseño de equipos, minimizando costos y tiempo de experimentación, a través de estrategias más amigables con el medio ambiente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Industrially, the use of enzymes has increased over time, as their production processes, stabilization and operating conditions have been optimized. Meanwhile associated with their use are minimized with environmental sustainability. The use of mathematical modeling has been a key factor in this advance, making it an &#8203;&#8203;great scientific interest area.  Objective: To know the state of the art in this area of knowledge, highlighting the most successful and promising findings at present.  Materials and Methods: A systematic search of recent high-impact publications between 2015 and 2021 was carried out in internationally recognized databases. A qualitative/comparative analysis of the approaches and contributions of the selected literature was carried out.  Results and Discussion: It was evidenced that most of the mathematical models was developed from the Michaelis-Menten kinetic equation, but the simplifications assumed, the operating conditions and the mathematical methods used to solve these systems define the singularity and complexity of each investigation, which makes complex their comparison or implementation in a standardized way.  Conclusions: In all cases, the proposed models were adjusted to experimental results or they agreed when different mathematical resolution methods were used. These results can provide valuable information for processes improvement and for equipment design, minimizing costs and time of experimentation and being more friendly to the environment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[cinética]]></kwd>
<kwd lng="es"><![CDATA[enzimas]]></kwd>
<kwd lng="es"><![CDATA[Michaelis-Menten]]></kwd>
<kwd lng="es"><![CDATA[modelación]]></kwd>
<kwd lng="es"><![CDATA[modelos matemáticos]]></kwd>
<kwd lng="en"><![CDATA[kinetics]]></kwd>
<kwd lng="en"><![CDATA[enzyme]]></kwd>
<kwd lng="en"><![CDATA[Michaelis-Menten]]></kwd>
<kwd lng="en"><![CDATA[Modeling]]></kwd>
<kwd lng="en"><![CDATA[Mathematical Models]]></kwd>
</kwd-group>
</article-meta>
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