<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212020000100061</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Triterpenes with anti-inflammatory activity isolated from the bark of the endemic species Maytenus elaeodendroides, Griseb]]></article-title>
<article-title xml:lang="es"><![CDATA[Triterpenos con actividad anti-inflamatoria aislados de la corteza de la especie endémica Maytenus elaeodendroides, Griseb]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández-Bobey]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández-Torriente]]></surname>
<given-names><![CDATA[Airovict]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-Pérez]]></surname>
<given-names><![CDATA[Trina Haydee]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Spengler-Salabarría]]></surname>
<given-names><![CDATA[Iraida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Centro de Estudios de Productos Naturales]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2020</year>
</pub-date>
<volume>32</volume>
<numero>1</numero>
<fpage>61</fpage>
<lpage>73</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212020000100061&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212020000100061&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212020000100061&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Several species from Maytenus genus (Celastraceae family) show anti-inflammatory activity associated to terpene presence. Thus we intend to isolate and characterize triterpenes having potential anti-inflammatory activity from the bark of Maytenus elaeodendroides Griseb. Isolation, purification and structural elucidation of such compounds were achieved by maceration with petroleum ether/diethyl ether (1:1), followed by chromatographic and spectroscopic methods. Anti-inflammatory activity was evaluated by inhibition of Croton oil- induced ear edema in mice. The triterpenes isolated were: 28-hydroxy-3-oxo-20(29)-lupene, 16-hydroxy-3-oxo-20(29)-lupene (herein found for the first time in the Celastraceae family), 3dihydroxy-20(29)-lupene and acid 3-oxo-20(29)-lupene-28-oic. At certain doses the obtained extract showed an anti-inflammatory effect as potent as that exhibited by diclofenac (reference drug). This is the first time it is reported an anti-inflammatory activity for 16-hydroxy-3-oxo-20(29)-lupene. An increase in the anti-inflammatory activity of this last terpene is probably related to the presence of carbonile group in C-3.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Varias especies del género Maytenus (Celastraceae) presentan actividad anti-inflamatoria atribuida a metabolitos del tipo triterpenoides. Por ello, el objetivo de este trabajo fue aislar y caracterizar triterpenos con potencial actividad anti-inflamatoria a partir de la corteza del Maytenus elaeodendroides Griseb. El aislamiento, purificación y elucidación estructural de tales compuestos se realizó mediante maceración con éter de petróleo/ éter dietílico (1:1), diferentes métodos cromatográficos y espectroscópicos. La actividad anti-inflamatoria fue evaluada mediante la inhibición en ratones del edema del oído, inducido por aceite de Croton. Los triterpenos aislados fueron: 28-hidroxi-3-oxo-20(29)-lupeno, 16-hidroxi-3-oxo-20(29)-lupeno (por primera vez aislado en la familia Celastraceae); 3dihidroxi-20(29)-lupeno y el ácido 3-oxo-20(29)-lupeno-28-oico. A ciertas dosis el extracto obtenido mostró efecto anti-inflamatorio tan potente como el mostrado por el diclofenaco (fármaco de referencia). Por primera vez se reporta actividad anti-inflamatoria del 16-hidroxi-3-oxo-20(29)-lupeno. El incremento en la actividad antinflamatoria de este triterpeno está relacionado con la presencia de un grupo carbonilo en C-3.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[maytenus elaeodendroides]]></kwd>
<kwd lng="en"><![CDATA[triterpenes]]></kwd>
<kwd lng="en"><![CDATA[anti-inflammatory activity]]></kwd>
<kwd lng="en"><![CDATA[Croton oil]]></kwd>
<kwd lng="es"><![CDATA[maytenus elaeodendroides]]></kwd>
<kwd lng="es"><![CDATA[triterpenos]]></kwd>
<kwd lng="es"><![CDATA[actividad anti-inflamatoria]]></kwd>
<kwd lng="es"><![CDATA[aceite de Croton]]></kwd>
</kwd-group>
</article-meta>
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