<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212021000200003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nanopartículas de Gd2O3 pegiladas y conjugadas a amylovis con potencial aplicación en la detección de alzheimer mediante RMI]]></article-title>
<article-title xml:lang="en"><![CDATA[Nanoparticles of Gd2O3 pegylated and conjugated to amylovis with potential application in the detection of alzheimer by MRI]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Izquierdo]]></surname>
<given-names><![CDATA[Julio Ricardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paneque-Quevedo]]></surname>
<given-names><![CDATA[Armando Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sablón-Carrazana]]></surname>
<given-names><![CDATA[Marquiza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Tanty]]></surname>
<given-names><![CDATA[Chryslaine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-García]]></surname>
<given-names><![CDATA[Alicia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Dalmau]]></surname>
<given-names><![CDATA[Evelio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Laboratorio de Bioinorgánica Departamento de Química General e Inorgánica]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Neurociencias de Cuba Departamento de Neuroquímica ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro de Neurociencias de Cuba Departamento de Resonancia Magnética ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2021</year>
</pub-date>
<volume>33</volume>
<numero>2</numero>
<fpage>3</fpage>
<lpage>22</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212021000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212021000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212021000200003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Los agentes de contrastes específicos facilitan el empleo de la Resonancia Magnética de Imágenes (RMI) en el diagnóstico precoz de la enfermedad de Alzheimer (EA). En el presente trabajo se desarrolla un procedimiento de síntesis de un potencial agente de contraste para IRM basado en partículas de Gd2O3 pegiladas para conjugarlas a Amylovis®, familia de compuestos que ha mostrado una alta afinidad por las estructuras patológicas presentes en la EA. Los productos obtenidos se caracterizaron por FT-IR, ICP, TGA, DLS y SEM. Las partículas de Gd2O3 funcionalizadas con Amylovis mostraron una morfología esférica, con un diámetro hidrodinámico promedio de 2,5 &#956;m. Dichas partículas presentaron un adecuado valor de la relación entre las relaxitividades longitudinal (r1) y transversal (r2) (r2/r1 = 2.4). Lo anterior sugiere que una vez logrado que dichas partículas presenten un diámetro hidrodinámico menor que 200 nm, pudieran ser empleadas como un potencial agente de contraste para IRM.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Specific contrast agents facilitate the use of Magnetic Resonance Imaging (MRI) in the early diagnosis of Alzheimer's disease (AD). In the present work, a procedure for the synthesis of a potential MRI contrast agent based on PEGylated Gd2O3 particles is developed for conjugation to Amylovis®, a family of compounds that has shown a high affinity for the pathological structures present in AD. The products obtained were characterized by FT-IR, ICP, TGA, DLS and SEM. Amylovis-functionalized Gd2O3 particles showed a spherical morphology, with an average hydrodynamic diameter of 2.5 &#956;m. These particles presented an adequate value of the ratio between the longitudinal (r1) and transversal (r2) relaxivities (r2/r1 = 2.4). This suggests that once these particles have a hydrodynamic diameter smaller than 200 nm, they could be used as a potential contrast agent for MRI.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad de alzheimer]]></kwd>
<kwd lng="es"><![CDATA[agentes de contraste]]></kwd>
<kwd lng="es"><![CDATA[nanopartículas]]></kwd>
<kwd lng="es"><![CDATA[óxido de gadolinio]]></kwd>
<kwd lng="es"><![CDATA[IRM]]></kwd>
<kwd lng="en"><![CDATA[alzheimer disease]]></kwd>
<kwd lng="en"><![CDATA[contrast agent]]></kwd>
<kwd lng="en"><![CDATA[nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[gadolinium oxide]]></kwd>
<kwd lng="en"><![CDATA[MRI]]></kwd>
</kwd-group>
</article-meta>
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<page-range>3</page-range></nlm-citation>
</ref>
</ref-list>
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</article>
