<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-5421</journal-id>
<journal-title><![CDATA[Revista Cubana de Química]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cub Quim]]></abbrev-journal-title>
<issn>2224-5421</issn>
<publisher>
<publisher-name><![CDATA[Ediciones UO, Universidad de Oriente]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-54212023000100029</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nanopartículas de Gd2O3 conjugadas a Amylovis®-204, con potencial afinidad por las placas &#946;-amiloides. Parte II]]></article-title>
<article-title xml:lang="en"><![CDATA[Gd2O3 nanoparticles grafted to Amylovis®-204, with potential affinity for &#946;-amyloid plaques. Part II]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Guerrero-Porras]]></surname>
<given-names><![CDATA[Gabriel Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sablón-Carrazana]]></surname>
<given-names><![CDATA[Marquiza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-García]]></surname>
<given-names><![CDATA[Alicia M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Tanty]]></surname>
<given-names><![CDATA[Chryslaine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Laboratorio de Bioinorgánica, Departamento de Química General e Inorgánica,]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Neurociencias de Cuba Dirección de Neurociencias Moleculares Laboratorio de Síntesis Orgánica, Departamento de Neuroquímica]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2023</year>
</pub-date>
<volume>35</volume>
<numero>1</numero>
<fpage>29</fpage>
<lpage>45</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-54212023000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-54212023000100029&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-54212023000100029&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Para la visualización por Resonancia Magnética de Imágenes (RMI) de los marcadores moleculares &#8212;péptido &#946;-amiloide (&#946;A)&#8212; de la enfermedad de Alzheimer, es necesario el empleo de agentes de contrastes (ACs). En la práctica clínica, la obtención de nanopartículas de óxido de gadolinio(III) (Gd2O3NPs) como ACs es un campo de investigación muy activo. En este trabajo se conjugó a Gd2O3NPs uno de los compuestos Amylovis®, derivados del naftaleno, obtenidos en CNEURO, con gran afinidad por el &#946;A. Las Gd2O3NPs se caracterizaron por FT-IR, TEM, TGA, DLS y Potencial &#950;. Por FT-IR y TEM, respectivamente. Se corroboró la funcionalización con grupos carboxilos y el tamaño de las Gd2O3NPs (&lt; 10 nm). Si bien la cantidad de Amylovis®-204 que se conjuga pude disminuir la estabilidad coloidal de las Gd2O3NPs, los valores de diámetros hidrodinámicos (&lt; 200 nm) y relaxitividad longitudinal de las Gd2O3NPs, justifican su empleo potencial como AC para el fin propuesto.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT For Magnetic Resonance Imaging (MRI) visualization of molecular markers &#8212;&#946;-amyloid peptide (&#946;A)&#8212; of Alzheimer's disease, the use of contrast agents (CAs) is necessary. In clinical practice, obtaining gadolinium(III) oxide nanoparticles (Gd2O3NPs) as ACs is a very active field of research. In this work, one of the Amylovis® compounds, naphthalene derivatives obtained at CNEURO with high affinity for &#946;A, was conjugated to Gd2O3NPs. The Gd2O3NPs were characterized by FT-IR, TEM, TGA, DLS and &#950;-potential. By FT-IR and TEM, respectively, the functionalization with carboxyl groups and the size of the Gd2O3NPs (&lt; 10 nm) were corroborated. Although the amount of Amylovis®-204 conjugated could decrease the colloidal stability of Gd2O3NPs, the values of hydrodynamic diameters (&lt; 200 nm) and longitudinal relaxivity of Gd2O3NPs justify their potential use as AC for the proposed purpose.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[nanopartículas de óxido de gadolinio(III)]]></kwd>
<kwd lng="es"><![CDATA[agente de contraste]]></kwd>
<kwd lng="es"><![CDATA[Amylovis®]]></kwd>
<kwd lng="es"><![CDATA[enfermedad de Alzheimer.]]></kwd>
<kwd lng="en"><![CDATA[gadolinium(III) oxide nanoparticles]]></kwd>
<kwd lng="en"><![CDATA[MRI contrast agent]]></kwd>
<kwd lng="en"><![CDATA[Amylovis®]]></kwd>
<kwd lng="en"><![CDATA[Alzheimer&#8217;s disease.]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[ESTRADA RODRÍGUEZ]]></surname>
<given-names><![CDATA[A. E.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Papel de la agregación del péptido Beta amiloide en la enfermedad de Alzheimer]]></article-title>
<source><![CDATA[Revista de Educación Bioquímica (REB)]]></source>
<year>2017</year>
<volume>36</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>2-11</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SÁNCHEZ-MÁRQUEZ]]></surname>
<given-names><![CDATA[N. I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dinámica familiar de pacientes con enfermedad de Alzheimer antes y después del inicio de la enfermedad]]></article-title>
<source><![CDATA[Pensando Psicología]]></source>
<year>2018</year>
<volume>14</volume>
<numero>24</numero>
<issue>24</issue>
<page-range>1-17</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SALERNO]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Alzheimer's disease: The use of contrast agents for magnetic resonance imaging to detect amyloid beta peptide inside the brain]]></article-title>
<source><![CDATA[Coordination Chemistry Reviews]]></source>
<year>2016</year>
<volume>327</volume>
<page-range>27-34</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AZRIA]]></surname>
<given-names><![CDATA[D.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer's disease diagnosis]]></article-title>
<source><![CDATA[Journal of Materials Chemistry B]]></source>
<year>2017</year>
<volume>5</volume>
<numero>35</numero>
<issue>35</issue>
<page-range>7216-37</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[SABLÓN CARRAZANA]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Drug development in conformational diseases: A novel family of chemical chaperones that bind and stabilise several polymorphic amyloid structures]]></article-title>
<source><![CDATA[PLOS ONE]]></source>
<year>2015</year>
<volume>10</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[BENCOMO MARTÍNEZ]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Identificación y caracterización in silico de la zona de interación entre el péptido beta-amiloide y compuestos derivados del naftaleno]]></article-title>
<source><![CDATA[Revista CENIC. Ciencias Químicas]]></source>
<year>2012</year>
<volume>43</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[RIVERA MARRERO]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[[18F]Amylovis as a Potential PET Probe for &#946;-Amyloid Plaque: Synthesis, in Silico, in vitro and in vivo Evaluations]]></article-title>
<source><![CDATA[Current Radiopharmaceuticals]]></source>
<year>2019</year>
<volume>12</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>58-71</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[FERNÁNDEZ GÓMEZ]]></surname>
<given-names><![CDATA[I.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diabetes drug discovery: hIAPP1-37 polymorphic amyloid structures as novel therapeutic targets]]></article-title>
<source><![CDATA[Molecules]]></source>
<year>2018</year>
<volume>23</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>686</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[RIVERA MARRERO]]></surname>
<given-names><![CDATA[S.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síntesis de nuevos derivados del naftaleno]]></article-title>
<source><![CDATA[Revista CENIC. Ciencias Químicas]]></source>
<year>2011</year>
<volume>42</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-32</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LAGAR SOSA]]></surname>
<given-names><![CDATA[Á.]]></given-names>
</name>
</person-group>
<source><![CDATA[Nanopartículas de óxido de hierro conjugadas con Amylovis por reacción de Ugi con potenciales aplicaciones como agente de contraste]]></source>
<year>2019</year>
<publisher-name><![CDATA[Universidad de La Habana]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GUZMÁN RODRÍGUEZ]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Síntesis y caracterización de nanopartículas de óxido de hierro funcionalizadas con derivados de Amylovis]]></article-title>
<source><![CDATA[Revista Cubana de Química]]></source>
<year>2022</year>
<volume>34</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>49-68</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[RODRÍGUEZ-IZQUIERDO]]></surname>
<given-names><![CDATA[J. R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Nanopartículas de Gd2O3 pegiladas y conjugadas a Amylovis con potencial aplicación en la detección de Alzheimer mediante RMI]]></article-title>
<source><![CDATA[Revista Cubana de Química]]></source>
<year>2021</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>3-22</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[GAYATHRI]]></surname>
<given-names><![CDATA[T.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gadolinium Oxide Nanoparticles for Magnetic Resonance Imaging and Cancer Theranostics]]></article-title>
<source><![CDATA[Journal of Bionanoscience]]></source>
<year>2015</year>
<volume>9</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>409-23</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AHRÉN]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A simple polyol-free synthesis route to Gd2O3 nanoparticles for MRI applications: an experimental and theoretical study]]></article-title>
<source><![CDATA[Journal of nanoparticle research]]></source>
<year>2012</year>
<volume>14</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1006</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[NAKAMOTO]]></surname>
<given-names><![CDATA[K.]]></given-names>
</name>
</person-group>
<source><![CDATA[Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic and Bioinorganic Chemistry]]></source>
<year>2009</year>
<publisher-name><![CDATA[John Wiley &amp; Sons, Inc. ed.; Wiley]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[PÉREZ MARTÍNEZ]]></surname>
<given-names><![CDATA[C. S.]]></given-names>
</name>
</person-group>
<source><![CDATA[Espectroscopia]]></source>
<year>2010</year>
<publisher-name><![CDATA[Ed. Féliz Varela]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[CAO]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gadolinium-based nanoscale MRI contrast agents for tumor imaging]]></article-title>
<source><![CDATA[Journal of Materials Chemistry B]]></source>
<year>2017</year>
<volume>5</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>3431-61</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[KIM]]></surname>
<given-names><![CDATA[H.-K.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gadolinium as an MRI contrast agent]]></article-title>
<source><![CDATA[Future Medicinal Chemistry]]></source>
<year>2018</year>
<volume>10</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>639-61</page-range></nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[FAUCHER]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rapid Synthesis of PEGylated Ultrasmall Gadolinium Oxide Nanoparticles for Cell Labeling and Tracking with MRI]]></article-title>
<source><![CDATA[ACS Applied Materials and Interfaces]]></source>
<year>2012</year>
<volume>4</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>4506-15</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[LI]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Gadolinium oxide nanoparticles and aptamer-functionalized silver nanoclusters-based multimodal molecular imaging nanoprobe for optical/magnetic resonance cancer cell imaging]]></article-title>
<source><![CDATA[Analytical Chemistry]]></source>
<year>2014</year>
<volume>86</volume>
<numero>22</numero>
<issue>22</issue>
<page-range>11306-11</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[AHMAD]]></surname>
<given-names><![CDATA[M. W.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Bovine serum albumin (BSA) and cleaved-BSA conjugated ultrasmall Gd2O3 nanoparticles: Synthesis, characterization, and application to MRI contrast agents]]></article-title>
<source><![CDATA[Colloids and Surfaces A: Physicochemical and Engineering Aspects]]></source>
<year>2014</year>
<volume>450</volume>
<page-range>67-75</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
