<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2224-7920</journal-id>
<journal-title><![CDATA[Revista de Producción Animal]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. prod. anim.]]></abbrev-journal-title>
<issn>2224-7920</issn>
<publisher>
<publisher-name><![CDATA[Ediciones Universidad de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2224-79202022000300056</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Evaluación de la toxicidad por dosis única oral de extractos de Dichrostachys cinerea en ratas]]></article-title>
<article-title xml:lang="en"><![CDATA[Toxicity Evaluation of a Single Oral Dose of Dichrostachys cinerea Extract in Rats]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Borges Espinosa]]></surname>
<given-names><![CDATA[Aida Yanet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marrero Chang]]></surname>
<given-names><![CDATA[Osmany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Seijo Wals]]></surname>
<given-names><![CDATA[Mirieisy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Díaz]]></surname>
<given-names><![CDATA[Aliette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lazo Pérez]]></surname>
<given-names><![CDATA[Leonel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reinoso Pérez]]></surname>
<given-names><![CDATA[Mario]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Departamento de Sanidad Animal de Villa Clara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Central &#8220;Marta Abreu&#8221; de Las Villas Laboratorio de Toxicología. Centro de Bioactivos Químicos ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Central &#8220;Marta Abreu&#8221; de Las Villas Departamento de Medicina Veterinaria y Zootecnia Facultad de Ciencias Agropecuarias]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>34</volume>
<numero>3</numero>
<fpage>56</fpage>
<lpage>64</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2224-79202022000300056&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2224-79202022000300056&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2224-79202022000300056&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Antecedentes:  El uso de la biomasa comestible de Dichrostachys cinerea podría ser una alternativa eficaz para el control de parasitosis en animales.  Objetivo.  Evaluar la toxicidad a dosis límite de un extracto de legumbres, rebrote y hojas de planta adulta de D. cinerea en ratas.  Métodos: Se utilizaron ratas adultas jóvenes de la especie Rattus norvegicus (variedad albina), de la línea o cepa Sprague Dawley (Cenp: SD), de ambos sexos, con un peso entre 150 y 200 g, consanguíneas y heteroxénicas. Se evaluaron tres extractos acuosos mediante maceración al 20% de biomasa vegetal de, rebrotes, hojas de planta adulta y legumbres, mediante el ensayo de toxicidad oral por dosis límite de 2000 mg / kg de masa corporal. Se controló la ocurrencia de mortalidad y la aparición de síntomas o signos de toxicidad. Se practicó necropsia y análisis macroscópico a los animales al final del estudio en busca de lesiones. Se empleó el paquete estadístico STATISTICA, versión 10 y se aplicaron los ensayos no paramétricos de Pares de Wilcoxon y U de Mann Whitney, para comparar el peso inicial y final por sexos y el incremento por sexos, respectivamente.  Resultados: Las ratas de ambos sexos incrementaron su masa corporal, lo que demuestra la no influencia negativa por la administración del extracto. Se observó diferencias significativas en el incremento de peso entre hembras y machos, no se observaron lesiones macroscópicas o alteraciones patológicas relacionadas o achacables a la administración del producto.  Conclusiones: El extracto acuoso de legumbres, rebrote y hojas de la planta D. cinerea, no resulta tóxico a dosis límite oral en ratas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  The utilization of edible biomass of Dichrostachys cinerea could become an effective alternative for the control of animal parasitosis.  Aim.  To evaluate toxicity at a limit dose of an extract of legumes, reshoots, and leaves of adult D. cinerea plants in rats.  Methods: The study comprised young-adult albino consanguineous and heteroxenic rats (Rattus norvegicus) of the Sprague Dawley (Cenp: SD) line, of both sexes, weighing between 150 and 200 g. Three aqueous extracts by 20% crushing from plant biomass, reshoots from the adult plants, and legumes were evaluated through an oral toxicity test with a limit dose of 2000 mg/kg body mass. Mortality and symptoms or signs of toxicity were controlled. A necropsy and microscopic analysis of the animals at the end of the study was performed to detect lesions. STATISTICA, version 10, was used, and the Wilcoxon and Man Whitney U non-parametric paired tests were performed to compare the initial and final weights by sexes, and weight gains by sexes, respectively.  Results: The rats from both sexes increased their body weight, demonstrating that the extract caused no negative effect. There were significant differences in weight gains between the males and females; no macroscopic lesions or pathological alterations associated with the administration of the product were observed.  Conclusions: The aqueous extract of legumes, reshoots, and leaves of adult D. cinerea plants administered to rats orally was not toxic at the limit oral dose in rats.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[dosis límite]]></kwd>
<kwd lng="es"><![CDATA[legumbre]]></kwd>
<kwd lng="es"><![CDATA[planta]]></kwd>
<kwd lng="es"><![CDATA[rebrote]]></kwd>
<kwd lng="en"><![CDATA[limit dose]]></kwd>
<kwd lng="en"><![CDATA[legume]]></kwd>
<kwd lng="en"><![CDATA[plant]]></kwd>
<kwd lng="en"><![CDATA[reshoots]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<nlm-citation citation-type="">
<collab>Animals Resources Centre</collab>
<source><![CDATA[Rodent Reference Information. Rat and Mice Weights]]></source>
<year>2021</year>
</nlm-citation>
</ref>
<ref id="B2">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Arece]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Roche]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[López]]></surname>
<given-names><![CDATA[Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Molina]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Efecto in vitro del extracto acuoso de Dichrostachys cinerea (L.) Wight &amp; Arn. en el desarrollo de las fases exógenas de estrongílidos gastrointestinales de ovinos]]></article-title>
<source><![CDATA[Pastos y Forrajes]]></source>
<year>2012</year>
<volume>35</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>301-10</page-range></nlm-citation>
</ref>
<ref id="B3">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Borges Espinosa]]></surname>
<given-names><![CDATA[A. Y.]]></given-names>
</name>
<name>
<surname><![CDATA[Reinoso Pérez]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Espinosa Ruiz]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
<name>
<surname><![CDATA[Avello Oliver]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actividad antihelmíntica &#8220;in vitro&#8221; de extractos acuosos obtenidos a partir de la biomasa comestible de Dichrostachys cinerea (L.) Wight et Arn]]></article-title>
<source><![CDATA[Revista de Producción Animal]]></source>
<year>2020</year>
<volume>32</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>92-102</page-range></nlm-citation>
</ref>
<ref id="B4">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dorta Contreras]]></surname>
<given-names><![CDATA[A. J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Aporte de Cuba al estudio de Angiostrongylus cantonensis]]></article-title>
<source><![CDATA[Acimed]]></source>
<year>2007</year>
<volume>16</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>0</page-range></nlm-citation>
</ref>
<ref id="B5">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Epe]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
<name>
<surname><![CDATA[Kaminsky]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[New advancement in anthelmintic drugs in veterinary medicine]]></article-title>
<source><![CDATA[TRENDS in Parasitology]]></source>
<year>2013</year>
<volume>29</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>129-34</page-range></nlm-citation>
</ref>
<ref id="B6">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hernández-Alvarado]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
<name>
<surname><![CDATA[Zaragoza-Bastida]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[López-Rodríguez]]></surname>
<given-names><![CDATA[G.]]></given-names>
</name>
<name>
<surname><![CDATA[Peláez-Acero]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Olmedo-Juárez]]></surname>
<given-names><![CDATA[A.]]></given-names>
</name>
<name>
<surname><![CDATA[Rivero-Perez]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Actividad antibacteriana y sobre nematodos gastrointestinales de metabolitos secundarios vegetales: enfoque en Medicina Veterinaria]]></article-title>
<source><![CDATA[Abanico veterinario]]></source>
<year>2018</year>
<volume>8</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>14-27</page-range></nlm-citation>
</ref>
<ref id="B7">
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Medina]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
<name>
<surname><![CDATA[Guevara]]></surname>
<given-names><![CDATA[F.]]></given-names>
</name>
<name>
<surname><![CDATA[La O]]></surname>
<given-names><![CDATA[M.]]></given-names>
</name>
<name>
<surname><![CDATA[Ojeda]]></surname>
<given-names><![CDATA[N.]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Resistencia antihelmíntica en ovinos: una revisión de informes del sureste de México y alternativas disponibles para el control de nemátodos gastrointestinales]]></article-title>
<source><![CDATA[Pastos y Forrajes]]></source>
<year>2014</year>
<volume>37</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>257-63</page-range></nlm-citation>
</ref>
<ref id="B8">
<nlm-citation citation-type="">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Repetto]]></surname>
<given-names><![CDATA[J.M.]]></given-names>
</name>
<name>
<surname><![CDATA[Repetto]]></surname>
<given-names><![CDATA[K.G]]></given-names>
</name>
</person-group>
<source><![CDATA[Toxicología fundamental. Cuarta Edición. Ediciones Díaz de Santo]]></source>
<year>2012</year>
<page-range>43</page-range></nlm-citation>
</ref>
<ref id="B9">
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Satyajit]]></surname>
<given-names><![CDATA[D.S.]]></given-names>
</name>
<name>
<surname><![CDATA[Lutfun]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
</person-group>
<source><![CDATA[An Introduction to Natural Products Isolation. En: Satyajit DS, Lutfun N. (eds.). Natural Products Isolation, Methods in Molecular Biology]]></source>
<year>2012</year>
<edition>3ra ed</edition>
<page-range>864</page-range><publisher-loc><![CDATA[UK ]]></publisher-loc>
<publisher-name><![CDATA[Humana Press Inc]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
