<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2304-0106</journal-id>
<journal-title><![CDATA[Anales de la Academia de Ciencias de Cuba]]></journal-title>
<abbrev-journal-title><![CDATA[Anales de la ACC]]></abbrev-journal-title>
<issn>2304-0106</issn>
<publisher>
<publisher-name><![CDATA[Academia de Ciencias de Cuba]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2304-01062024000300009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Complejos metálicos con propiedades anticancerígenas de aciltioureas]]></article-title>
<article-title xml:lang="en"><![CDATA[Metal complexes with anticancer properties of acyl thioureas]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Plutín Stevens]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Azevedo Batista]]></surname>
<given-names><![CDATA[Alzir]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos Cairo]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mocelo Castell]]></surname>
<given-names><![CDATA[Raúl Oscar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castellano]]></surname>
<given-names><![CDATA[Eduardo E.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cominetti]]></surname>
<given-names><![CDATA[Marcia R.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Flores Muñoz]]></surname>
<given-names><![CDATA[Daniela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Química Laboratorio de Síntesis Orgánica]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Federal de San Carlos Departamento de Química Laboratorio de Estructura y Reactividad de Compuestos Inorgánicos]]></institution>
<addr-line><![CDATA[ Sao Paulo]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidade de Sao Paulo Instituto de Física de San Carlos ]]></institution>
<addr-line><![CDATA[ Sao Paulo]]></addr-line>
<country>Brasil</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidade Federal de San Carlos Departamento de Gerontología ]]></institution>
<addr-line><![CDATA[ Sao Paulo]]></addr-line>
<country>Brasil</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2024</year>
</pub-date>
<volume>14</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2304-01062024000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2304-01062024000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2304-01062024000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Introducción: Los iones metálicos y sus complejos son vitales en el sistema biológico humano. Están diseñados para apuntar a sitios biológicos específicos debido a su amplia gama de geometrías, características de coordinación e interactúan con las moléculas biológicas. Muchos compuestos quimioterapéuticos clásicos han demostrado no solo actividades antitumorales, sino también una acción antiviral inesperada.  Objetivo: Obtener, caracterizar, determinar la estructura y evaluar la actividad citotóxica de complejos y ligandos.  Métodos: Las aciltioureas y complejos metálicos reportados se aislaron y caracterizaron mediante técnicas espectroscópicas, y se evaluó la actividad citotóxica de ligandos y complejos; para uno de los complejos se realizó el experimento tridimensional para células tumorales en cultivos.  Resultados: Se sintetizaron N-alquil- y N,N-dialquil-N&#8242;-aciltioureas para la obtención de complejos metálicos con diferentes precursores, análisis elemental, conductividad molar, voltametría cíclica, Espectroscopia Infrarroja, Resonancia Magnética Nuclear (1H, 13C { 31P{1H }), y difracción de rayos X. La citotoxicidad de los compuestos fue evaluada en líneas celulares de tumores de pulmón, próstata y mama.  Conclusiones: Se sintetizaron 38 complejos metálicos de Pd(II), Pt(II), Ni(II), Cu(I), Ru(II), con aciltioureas. Las coordinaciones más comunes para estos compuestos son a través del átomo de azufre, oxígeno del grupo tioureido. Los complejos muestran una alta citotoxicidad contra las células tumorales probadas, cuando se comparan con el IC50 reportado para el cisplatino y el complejo encapsulado trans ENT#091;Ru(PPh3)2(N,N-dimetil-N&#8242;-tiofeniltioureato- k2O,S)(bipy)ENT#093; PF6 presentó una mayor citotoxicidad, selectividad y es una estrategia prometedora para aumentar su solubilidad, administración y bioacumulación en tumores de mama.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Metal ions and their complexes are vital in the human biological system. They are designed to target specific biological sites due to their wide range of geometries, coordination characteristics, and interaction with biological molecules. Many classical chemotherapeutic compounds have demonstrated not only antitumor activities but also unexpected antiviral action.  Objective: To obtain, characterize, determine the structure and evaluate the cytotoxic activity of complexes and ligands.  Methods: The reported acylthioureas and metal complexes were isolated and characterized by spectroscopic techniques, and the cytotoxic activity of ligands and complexes was evaluated and for one of the complexes, the experiment was carried out in three-dimensional cultures for tumor cells.  Results: N-alkyl- and N,N- dialkyl-N&#8242;-acylthioureas were synthesized to obtain metal complexes with different precursors, elemental analysis, molar conductivity, cyclic voltammetry, Insulin Resistance, Nuclear Magnetic Resonance (1H, 13C {31P{1H}), and X-ray diffraction. The cytotoxicity of the compounds was evaluated in lung, prostate and breast tumor cell lines.  Conclusions: Thirty-eight metal complexes of Pd(II), Pt(II), Ni(II), Cu(I), Ru(II) with acylthioureas were synthesized. The most common coordination for these compounds is through the sulfur oxygen atom of the thioureide group. The complexes show high cytotoxicity against the tumor cells tested, when compared to the IC50 reported for cisplatin and the trans-encapsulated complex ENT#091;Ru(PPh3)2(N,N-dimethyl-N&#8242;-thiophenylthiourate-k2O,S)( bipy)ENT#093;PF6 presented greater cytotoxicity, selectivity and is a promising strategy to increase its solubility, delivery and bioaccumulation in breast tumors.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[aciltiourea]]></kwd>
<kwd lng="es"><![CDATA[complejo metálico]]></kwd>
<kwd lng="es"><![CDATA[citotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[fosfina]]></kwd>
<kwd lng="es"><![CDATA[microemulsión]]></kwd>
<kwd lng="en"><![CDATA[acylthiourea]]></kwd>
<kwd lng="en"><![CDATA[metal complexes]]></kwd>
<kwd lng="en"><![CDATA[cytotoxicity]]></kwd>
<kwd lng="en"><![CDATA[phosphine]]></kwd>
<kwd lng="en"><![CDATA[microemulsion]]></kwd>
</kwd-group>
</article-meta>
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