<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2307-2113</journal-id>
<journal-title><![CDATA[Revista Cubana de Información en Ciencias de la Salud]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. cuba. inf. cienc. salud]]></abbrev-journal-title>
<issn>2307-2113</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2307-21132021000200005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nextstrain: una herramienta que analiza la epidemiología molecular del SARS-CoV-2]]></article-title>
<article-title xml:lang="en"><![CDATA[Nextstrain: a tool to analyze the molecular epidemiology of SARS-CoV-2]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Iglesias-Osores]]></surname>
<given-names><![CDATA[Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Alcántara-Mimbela]]></surname>
<given-names><![CDATA[Miguel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arce-Gil]]></surname>
<given-names><![CDATA[Zhandra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Córdova-Rojas]]></surname>
<given-names><![CDATA[Lizbeth M.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-López]]></surname>
<given-names><![CDATA[Elmer]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rafael-Heredia]]></surname>
<given-names><![CDATA[Arturo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Pedro Ruiz Gallo Facultad de Ciencias Biológicas ]]></institution>
<addr-line><![CDATA[ Lambayeque]]></addr-line>
<country>Perú</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Católica Santo Toribio de Mogrovejo Facultad de Medicina Humana ]]></institution>
<addr-line><![CDATA[ Chiclayo]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Jaén  ]]></institution>
<addr-line><![CDATA[ Cajamarca]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad Señor de Sipán Facultad de Medicina Humana ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af5">
<institution><![CDATA[,Facultad de Medicina Humana de la Universidad Nacional de Ucayali  ]]></institution>
<addr-line><![CDATA[ Ucayali]]></addr-line>
<country>Perú</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>32</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2307-21132021000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2307-21132021000200005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2307-21132021000200005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La preocupación mundial por el nuevo coronavirus (2019-nCoV), como una amenaza global para la salud pública, fue el motor para que los análisis filogenéticos sufrieran un crecimiento exponencial. El objetivo de esta revisión fue describir el modo de funcionamiento y las bondades de la herramienta Nextstrain, así como el secuenciamiento del virus SARS-CoV-2 en el mundo. Se uso la interfaz de la página de Nextstrain para mostrar sus funcionalidades y los modos de visualización de datos, y se descargaron estos de la web GISAID para mostrar la cantidad de secuenciamientos del SARS-CoV-2 hasta la fecha. Nextstrain es un proyecto de código abierto creado por biólogos bioinformáticos, para aprovechar el potencial científico y de salud pública de los datos de genomas de patógenos. Nextstrain consiste en un conjunto de herramientas que toman secuencias sin procesar (en formato FASTA). Nextstrain realiza una alineación de secuencia de los datos de entrada en alineación de secuencia múltiple basada en la transformación rápida de Fourier. Se basa en el uso de dos softwares: Augur y Auspice. Nextstrain es una herramienta eficaz para mostrar datos epidemiológicos de manera simple para un público no especializado. Puede ser usado en la salud pública, ya que muestra datos en tiempo real de las epidemias y su distribución geográfica. Se puede usar para dar seguimiento a los brotes como es el caso del COVID-19.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Worldwide concern about the novel coronavirus (2019-nCoV) as a global threat to public health is the reason for the exponential growth of phylogenetic analyses. The purpose of this review was to describe the mode of operation and advantages of the tool Nextstrain, as well as the sequencing of the SARS-CoV-2 virus worldwide. The interface of the Nextstrain page was used to show its functions and data visualization modes. These were downloaded from the website GISAID to show the number of SARS-CoV-2 sequencing processes performed so far. Nextstrain is an open code project created by bioinformatics biologists to make good use of the scientific and public health potential of data about genomes of pathogens. Nextstrain consists in a set of tools operating with unprocessed sequences (in FASTA format). Nextstrain performs a sequence alignment of the input data into a multiple sequence alignment based on fast Fourier transform. Its use is based on two software applications: Augur and Auspice. Nextstrain is an efficient tool by which lay people may obtain epidemiological data in a simple manner. It may be used in the public health sector, since it shows real time data about epidemics and their geographic distribution. It may also be used to follow-up outbreaks, as is the case with COVID-19.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Filogenética]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[Nexstrain]]></kwd>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="en"><![CDATA[Phylogenetics]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV-2]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[Nextstrain]]></kwd>
<kwd lng="en"><![CDATA[epidemiology]]></kwd>
</kwd-group>
</article-meta>
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