<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272020000300376</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La COVID-19 en pacientes pediátricos, los dos primeros casos diagnosticados en la Provincia de Villa Clara]]></article-title>
<article-title xml:lang="en"><![CDATA[COVID-19 in pediatric patients, first two cases diagnosed in Villa Clara]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Sandeliz]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Machado Díaz]]></surname>
<given-names><![CDATA[Marbin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Marrero]]></surname>
<given-names><![CDATA[Fidel Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Pediátrico Universitario &#8220;José Luis Miranda&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>14</volume>
<numero>3</numero>
<fpage>376</fpage>
<lpage>382</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272020000300376&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272020000300376&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272020000300376&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la epidemia por el nuevo coronavirus fue informada en diciembre de 2019 en Wuhan, China, y declarada en marzo una emergencia internacional por la Organización Mundial de la Salud; progresó a pandemia y está asociada a unas altas morbilidad y mortalidad.  Información del paciente:  se presentan los dos primeros casos clínicos de adolescentes, ambas femeninas, del Municipio de Camajuaní, que fueron diagnosticadas como positivos al coronavirus. Se realizó una revisión actualizada del tema y de las diferentes opciones de tratamiento. Ambas pacientes fueron tratadas con oseltamivir y azitromicina según el protocolo vigente en ese momento al diagnóstico. Las pacientes presentaron reacción en cadena de polimerasa con transcriptasa reversa negativa para el virus a los 15 días de iniciados los síntomas.  Conclusiones:  en ambos casos se constataron manifestaciones inespecíficas y predominaron los síntomas respiratorios altos, hubo historia epidemiológica positiva para casos confirmados previamente y presentaron evolución satisfactoria sin complicaciones.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  the new coronavirus epidemic was reported in December 2019 in Wuhan, China, and declared an international emergency by the World Health Organization in March; it progressed to a pandemic and is associated with high morbidity and mortality.  Case report:  the first two clinical cases of adolescents, both female, from the Municipality of Camajuaní, were diagnosed as positive for the coronavirus. An updated review of the subject and of the different treatment options was carried out. Both patients were treated with oseltamivir and azithromycin according to the protocol in force at the time of diagnosis. The patients presented polymerase chain reaction with negative reverse transcriptase for the virus 15 days after the onset of symptoms.  Conclusions:  in both cases, non-specific manifestations were found and high respiratory symptoms were predominant, there was a positive epidemiological history for previously confirmed cases and they presented satisfactory evolution without complications.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[infecciones por Coronavirus]]></kwd>
<kwd lng="es"><![CDATA[Covid-19]]></kwd>
<kwd lng="es"><![CDATA[pediatría]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico]]></kwd>
<kwd lng="en"><![CDATA[Coronavirus infections]]></kwd>
<kwd lng="en"><![CDATA[Covid-19]]></kwd>
<kwd lng="en"><![CDATA[pediatrics]]></kwd>
<kwd lng="en"><![CDATA[diagnosis]]></kwd>
</kwd-group>
</article-meta>
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