<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272021000200176</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Respuesta terapéutica de la hipoplasia de timo con biomodulina T]]></article-title>
<article-title xml:lang="en"><![CDATA[Therapeutic response of thymus hypoplasia with biomodulin T]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Madrigal Mora]]></surname>
<given-names><![CDATA[Liovesky]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Naranjo Herrera]]></surname>
<given-names><![CDATA[Yralys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[León Márquez]]></surname>
<given-names><![CDATA[Cándido Marcos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yanes Milián]]></surname>
<given-names><![CDATA[Belkis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Del Sol Fabregat]]></surname>
<given-names><![CDATA[Luis Alberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Martínez]]></surname>
<given-names><![CDATA[Eudaldo Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Provincial Universitario &#8220;Camilo Cienfuegos Gorriarán&#8221;  ]]></institution>
<addr-line><![CDATA[Sancti Spíritus Sancti Spíritus]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>15</volume>
<numero>2</numero>
<fpage>176</fpage>
<lpage>187</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272021000200176&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272021000200176&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272021000200176&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  las inmunodeficiencias congénitas son defectos génicos que con frecuencia se manifiestan precozmente, durante la lactancia o la infancia, aunque a veces se detectan clínicamente en fases posteriores de la vida. Dentro de sus trastornos se encuentran los relacionados con uno de los órganos primarios de la respuesta inmune, el timo.  Objetivo:  describir el resultado del tratamiento con biomodulina T y los factores asociados que afectan a la población en estudio.  Métodos:  se realizó una investigación de desarrollo, descriptiva, longitudinal y prospectiva en niños de seis meses a siete años con infecciones recurrentes e hipoplasia del timo diagnosticado en las Consultas de Inmunología de la Provincia de Sancti Spíritus en el período comprendido desde noviembre de 2017 hasta octubre de 2020. La muestra quedó conformada por un total de 49 pacientes. Se utilizó como técnica el ultrasonido de timo, un cuestionario elaborado al efecto y la aplicación de la biomodulina T como tratamiento inmunomodulador.  Resultados:  predominaron los pacientes con hipoplasia de timo moderada, del sexo masculino, en el grupo etario pre-escolar, con infecciones respiratorias recurrentes no complicadas y antecedentes prenatales de sepsis urinaria. La mayoría de los pacientes mostraron una respuesta satisfactoria, tanto clínica como imagenológica, al tratamiento con biomodulina T.  Conclusiones:  la utilización de biomodulina T como terapia inmunomoduladora mostró resultados satisfactorios, tanto clínicos como imagenológicos, en la mayoría de los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  congenital immunodeficiencies are gene defects that often manifest early, during infancy or childhood, although sometimes they are clinically detected later in life. Among their disorders are those related to one of the primary organs of the immune response, the thymus.  Objective:  to describe the outcome of treatment with biomodulin T and the associated factors affecting the study population.  Methods:  a developmental, descriptive, longitudinal and prospective research was carried out in children from six months to seven years old with recurrent infections and hypoplasia of the thymus diagnosed in the Immunology Consultations of Sancti Spíritus Province in the period from November 2017 to October 2020. The sample was conformed by a total of 49 patients. Thymus ultrasound, a questionnaire elaborated for this purpose and the application of biomodulin T as immunomodulatory treatment were used as a technique.  Results:  patients with moderate thymus hypoplasia, male, in the preschool age group, with recurrent uncomplicated respiratory infections and prenatal history of urinary sepsis predominated. Most of the patients showed a satisfactory clinical and imaging response to treatment with T biomodulin.  Conclusions:  the use of biomodulin T as immunomodulatory therapy showed satisfactory results, both clinical and imaging, in most patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hipoplasia del timo]]></kwd>
<kwd lng="es"><![CDATA[Biomodulina T]]></kwd>
<kwd lng="es"><![CDATA[inmunomodulador]]></kwd>
<kwd lng="es"><![CDATA[ultrasonido de timo]]></kwd>
<kwd lng="en"><![CDATA[thymus hypoplasia]]></kwd>
<kwd lng="en"><![CDATA[Biomodulin T]]></kwd>
<kwd lng="en"><![CDATA[immunomodulator]]></kwd>
<kwd lng="en"><![CDATA[thymus ultrasound]]></kwd>
</kwd-group>
</article-meta>
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