<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272022000400782</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[COVID-19 pediátrico: respuesta inmune y cuadro clínico]]></article-title>
<article-title xml:lang="en"><![CDATA[Pediatric COVID-19: immune response and clinical picture]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Moldón]]></surname>
<given-names><![CDATA[Yarimi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés Cabodevilla]]></surname>
<given-names><![CDATA[Regla Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leyva Montero]]></surname>
<given-names><![CDATA[María de los Ángeles]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Escuela Superior Politécnica de Chimborazo  ]]></institution>
<addr-line><![CDATA[Riobamba ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>16</volume>
<numero>4</numero>
<fpage>782</fpage>
<lpage>797</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272022000400782&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272022000400782&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272022000400782&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la COVID-19 afecta menos a los niños que a las personas adultas. La respuesta inmune innata y adaptativa juega un papel importante en el control de la infección por el SARS-CoV-2.  Objetivo:  describir las características de la respuesta inmune en los niños con la COVID-19 y los principales síntomas clínicos.  Métodos:  se realizó una revisión bibliográfica, se seleccionaron los descriptores COVID-19 y SARS-CoV-2, se buscaron artículos completos en inglés y español en Google Académico, PubMed Central y SciELO. Se revisaron artículos de revistas y páginas de organizaciones internacionales reconocidas.  Desarrollo:  se analiza el papel de la respuesta inmune innata y adquirida en la resistencia de la población pediátrica a la infección al SARS-CoV-2. La primera línea de defensa la aporta la inmunidad innata a nivel de las mucosas, luego actúan la inmunidad humoral con la síntesis por los linfocitos B (activados a células plasmáticas) de anticuerpos o inmunoglobulinas contra el virus y la inmunidad celular con la activación de los linfocitos T.  Conclusiones: a diferencia de las infecciones de las vías respiratorias causadas por otros virus, el SARS-CoV-2 tiene un menor impacto en la salud de los niños en comparación con los adultos; sin embargo, se han observado casos de enfermedad grave. El resultado favorable de la infección por SARS-CoV-2 en los niños sugiere que una respuesta inmunitaria innata robusta y temprana podría desempeñar un papel importante. La experiencia adquirida con la COVID-19 será muy importante para la prevención y la atención de otras infecciones que afectan a los niños y para los patógenos que causarán futuras pandemias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  COVID-19 affects children less than adults. The innate and adaptive immune response plays an important role in the control of SARS-CoV-2 infection.  Objective:  to describe the characteristics of the immune response in children with COVID-19 and the main clinical symptoms.  Methods:  a literature review was performed, the descriptors COVID-19 and SARS-CoV-2 were selected, full articles in English and Spanish were searched in Google Scholar, PubMed Central and SciELO. Journal articles and pages of recognized international organizations were reviewed.  Development:  the role of the innate and acquired immune response in the resistance of the pediatric population to SARS-CoV-2 infection is analyzed. The first line of defense is provided by innate immunity at mucosal level, followed by humoral immunity with the synthesis by B lymphocytes (activated to plasma cells) of antibodies or immunoglobulins against the virus and cellular immunity with the activation of T lymphocytes.  Conclusions:  in contrast to respiratory tract infections caused by other viruses, SARS-CoV-2 has less impact on the health of children compared to adults; however, cases of severe disease have been observed. The favorable outcome of SARS-CoV-2 infection in children suggests that a robust early innate immune response may play an important role. The experience gained with Covid-19 will be very important for the prevention and care of other infections affecting children and for pathogens that will cause future pandemics.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Covid-19]]></kwd>
<kwd lng="es"><![CDATA[respuesta inmune]]></kwd>
<kwd lng="es"><![CDATA[sintomatología]]></kwd>
<kwd lng="es"><![CDATA[síndrome inflamatorio multisistémico]]></kwd>
<kwd lng="en"><![CDATA[Covid-19]]></kwd>
<kwd lng="en"><![CDATA[immune response]]></kwd>
<kwd lng="en"><![CDATA[symptomatology]]></kwd>
<kwd lng="en"><![CDATA[multisystem inflammatory syndrome]]></kwd>
</kwd-group>
</article-meta>
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</ref>
</ref-list>
</back>
</article>
