<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272023000200212</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hepatopatías crónicas en la edad pediátrica]]></article-title>
<article-title xml:lang="en"><![CDATA[Chronic liver diseases in the pediatric age]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz Ramos]]></surname>
<given-names><![CDATA[Anisbel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abreu Duarte]]></surname>
<given-names><![CDATA[Rafael]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Coello Rodríguez]]></surname>
<given-names><![CDATA[Marianelis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Meras Valdesuso]]></surname>
<given-names><![CDATA[Ángel Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lara Martín]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gómez Vera]]></surname>
<given-names><![CDATA[Ivis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Pediátrico Universitario &#8220;José Luis Miranda&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Provincial de Higiene, Epidemiología y Microbiología  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Policlínico Docente &#8220;50 Aniversario&#8221;  ]]></institution>
<addr-line><![CDATA[Manicaragua Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>212</fpage>
<lpage>221</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272023000200212&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272023000200212&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272023000200212&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  las hepatopatías crónicas son un grupo de enfermedades que a mediano o largo plazo producen alteraciones estructurales y funcionales en el hígado, el niño afectado puede padecer un espectro de complicaciones, con algunas similitudes respecto al adulto, pero con diferencias notables.  Objetivo:  caracterizara los pacientes pediátricos con hepatopatías crónicas atendidos en el Servicio de Gastroenterología del Hospital &#8220;José Luis Miranda&#8221; en el período de enero de 2019 a diciembre de 2020.  Métodos:  se realizó un estudio descriptivo transversal en pacientes pediátricos con diagnóstico de hepatopatías crónicas ingresados en el Servicio de Gastroenterología del Hospital &#8220;José Luis Miranda&#8221; enmarcado en el período enero de 2019 a diciembre de 2020. La población quedó constituida por 32 pacientes.  Resultados:  hubo un predominio de los menores de seis meses (50%) y del sexo femenino (59,39%). Entre las causas de hepatopatía la atresia de las vías biliares extra hepáticas se diagnosticó en el 18,75% de los pacientes a término, con adecuado peso al nacer. La hipertransaminasemia estuvo presente en el 100% de los casos como hallazgo de laboratorio predominante. Los principales tratamientos empleados fueron las vitaminas liposolubles y los quelantes de sales biliares.  Conclusiones:  las hepatopatías crónicas predominaron en el menor de seis meses, del sexo femenino. La atresia biliar extrahepática, la hepatotoxicidad y el síndrome de Alagille fueron las principales hepatopatías crónicas encontradas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  chronic liver diseases are a group of diseases that in the medium or long term produce structural and functional alterations in the liver, the affected child may suffer a spectrum of complications, with some similarities with respect to adults, but with notable differences.  Objective:  to characterize pediatric patients with chronic hepatopathies seen at the Gastroenterology Service of the &#8220;José Luis Miranda&#8221; Hospital in the period from January 2019 to December 2020.  Methods:  a cross-sectional descriptive study was conducted in pediatric patients with a diagnosis of chronic liver disease admitted to the Gastroenterology Department of the &#8220;José Luis Miranda&#8221; Hospital from January 2019 to December 2020. The population consisted of 32 patients.  Results:  there was a predominance of patients younger than six months (50%) and female sex (59.39%). Among the causes of liver disease, atresia of the extrahepatic biliary tract was diagnosed in 18.75% of patients at term, with adequate birth weight. Hypertransaminasemia was present in 100% of cases as the predominant laboratory finding. The main treatments used were fat-soluble vitamins and bile salt chelators.  Conclusions:  chronic hepatopathies were predominant in female children under six months of age. Extrahepatic biliary atresia, hepatotoxicity and Alagille syndrome were the main chronic liver diseases found.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hepatopatía crónica]]></kwd>
<kwd lng="es"><![CDATA[paciente pediátrico, tratamientos]]></kwd>
<kwd lng="en"><![CDATA[chronic liver disease]]></kwd>
<kwd lng="en"><![CDATA[pediatric patient, treatments]]></kwd>
</kwd-group>
</article-meta>
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