<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272023000200332</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tumor de células gigantes malignizado: a propósito de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Malignant transformation of a Giant Cell Tumor: a case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Álvarez López]]></surname>
<given-names><![CDATA[Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Delgado]]></surname>
<given-names><![CDATA[Maikel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Lorenzo]]></surname>
<given-names><![CDATA[Yenima de la Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Creagh García]]></surname>
<given-names><![CDATA[Johenis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Pediátrico Universitario &#8220;Dr. Eduardo Agramonte Piña&#8221;  ]]></institution>
<addr-line><![CDATA[Camagüey Camagüey]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Manuel Ascunce Domenech&#8221;  ]]></institution>
<addr-line><![CDATA[Camagüey Camagüey]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Policlínico Universitario &#8220;Tula Aguilera&#8221;  ]]></institution>
<addr-line><![CDATA[Camagüey Camagüey]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>332</fpage>
<lpage>339</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272023000200332&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272023000200332&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272023000200332&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la rodilla es la región anatómica en la que asientan la mayor cantidad de tumores benignos y malignos que afectan el esqueleto humano, entre ellos el tumor de células gigantes.  Información del paciente:  masculino, de 28 años de edad, blanco, sin antecedentes mórbidos de salud, que acudió a la Consulta externa de Ortopedia y Traumatología por presentar una tumoración a nivel de la rodilla derecha acompañada de dolor que apareció hace dos años, pero ha incrementado su tamaño de forma rápida en los últimos dos meses. Se le realizaron exámenes imagenológicos y toma de biopsia incisional para confirmar el diagnóstico. El equipo multidisciplinario decidió la amputación de la extremidad.  Conclusiones:  el tumor de células gigantes es una enfermedad que se presenta con mayor frecuencia desde la tercera a la quinta décadas de la vida, sus complicaciones principales son la recidiva, las metástasis pulmonares y la transformación maligna. Los enfermos con esta última complicación necesitan de procedimientos como la amputación de la extremidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  the knee is the anatomical region where most benign and malignant tumors affecting the human skeleton are found, including giant cell tumor.  Patient information:  male, 28 years old, white, with no morbid health history, who came to the Orthopedics and Traumatology outpatient clinic for presenting a tumor at the level of the right knee accompanied by pain that appeared two years ago, but has increased in size rapidly in the last two months. Imaging tests and incisional biopsy were performed to confirm the diagnosis. The multidisciplinary team decided to amputate the limb.  Conclusions:  giant cell tumor is a disease that occurs more frequently from the third to the fifth decade of life; its main complications are recurrence, pulmonary metastasis and malignant transformation. Patients with the latter complication require procedures such as limb amputation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tumor de células gigantes]]></kwd>
<kwd lng="es"><![CDATA[transformación maligna]]></kwd>
<kwd lng="es"><![CDATA[amputación]]></kwd>
<kwd lng="en"><![CDATA[giant cell tumor]]></kwd>
<kwd lng="en"><![CDATA[malignant transformation]]></kwd>
<kwd lng="en"><![CDATA[amputation]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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