<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272023000200349</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Hurler. Informe de caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Hurler syndrome. Case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaviano Cárdenas]]></surname>
<given-names><![CDATA[Yailén]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Céspedes Cárdenas]]></surname>
<given-names><![CDATA[Jarvis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Calvo]]></surname>
<given-names><![CDATA[María Dolores]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Policlínico Docente &#8220;José Ramón León Acosta&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>349</fpage>
<lpage>355</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272023000200349&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272023000200349&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272023000200349&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el síndrome de Hurler pertenece a un grupo de enfermedades llamadas muco polisacaridosis y es una rara enfermedad en la edad pediátrica.  Información del paciente:  adolescente masculino de 12 años de edad, producto de parto normal, que a los dos años comenzó con pérdida del habla y babeo constante. Fue valorado por el Especialista en Genética que, debido a sus características fenotípicas, sospechó un posible síndrome de Hurler. Se presenta un caso interesante, no comúnmente visto en la práctica médica, con el objetivo de dar a conocer a estudiantes y profesionales de la salud las características físicas del paciente, que ha tenido una supervivencia mayor de los 10 años de vida.  Conclusiones:  el diagnóstico se confirmó por estudio de cromatografía de mucopolisacáridos realizado en el Centro Nacional de Genética. Los pacientes a menudo mueren en la primera década de la vida debido a complicaciones respiratorias y cardíacas, el trasplante de precursores hematopoyéticos y la terapia enzimática con alfa-L-iduronidasa pueden mejorar la esperanza de vida.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Hurler syndrome belongs to a group of diseases called muco polysaccharidosis and is a rare disease in pediatric age.  Patient information:  12-year-old male adolescent, product of normal delivery, who at the age of two years started with loss of speech and constant drooling. He was evaluated by the Genetics Specialist who, due to his phenotypic characteristics, suspected a possible Hurler syndrome. We present an interesting case, not commonly seen in medical practice, with the aim of informing students and health professionals about the physical characteristics of the patient, who has survived more than 10 years of life.  Conclusions:  the diagnosis was confirmed by mucopolysaccharide chromatography study performed at the National Genetics Center. Patients often die in the first decade of life due to respiratory and cardiac complications, hematopoietic precursor transplantation and enzyme therapy with alpha-L-iduronidase can improve life expectancy.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[mucopolisacaridosis I]]></kwd>
<kwd lng="es"><![CDATA[síndrome de Hurler]]></kwd>
<kwd lng="es"><![CDATA[alfa-L-iduronidasa]]></kwd>
<kwd lng="en"><![CDATA[mucopolysaccharidosis I]]></kwd>
<kwd lng="en"><![CDATA[Hurler syndrome]]></kwd>
<kwd lng="en"><![CDATA[alpha-L-iduronidase]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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