<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272023000200363</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Neuralgia del trigémino, fisiopatología. Consideraciones en su etiología]]></article-title>
<article-title xml:lang="en"><![CDATA[Trigeminal neuralgia, pathophysiology. Considerations in its etiology]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lahera Fernández]]></surname>
<given-names><![CDATA[Ena Luisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Falcón]]></surname>
<given-names><![CDATA[Marisol]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz López]]></surname>
<given-names><![CDATA[Odalis Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>2</numero>
<fpage>363</fpage>
<lpage>373</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272023000200363&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272023000200363&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272023000200363&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la neuralgia del trigémino ha sido referida desde la antigüedad como uno de los dolores faciales más intensos; su etiología es controversial y su prevalencia asciende junto con la expectativa de vida.  Objetivo:  integrar criterios sobre la etiología de la neuralgia trigeminal.  Métodos:  revisión documental a través de una búsqueda automatizada en las bases de datos PubMed/Medline, Cochrane Library, Scielo, Medigraphic y Science Direct, mediante el motor de búsqueda Google Académico, durante el período de marzo de 2021 hasta igual mes de 2022. Se seleccionaron 31 artículos relacionados con el objetivo propuesto; 23 (74,2%) están actualizados.  Resultados:  los factores causales de la neuralgia trigeminal (traumatismos, enfermedades infecciosas y compresión por estructuras anatómicas vecinas o tumores) promueven un proceso inflamatorio en el tejido conectivo que compone al nervio, la liberación de productos leucocitarios provoca su destrucción y el tejido nervioso queda expuesto; se desencadenan potenciales de acción que ocasionan los síntomas dolorosos propios de la enfermedad.  Conclusiones:  el desarrollo de un proceso inflamatorio en el tejido conectivo constituyente del nervio trigémino ocasiona una disminución en el umbral de excitabilidad de las fibras afectadas y provoca dolor ante diversos estímulos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  trigeminal neuralgia has been referred since ancient times as one of the most intense facial pains; its etiology is controversial and its prevalence rises along with life expectancy.  Objective:  to integrate criteria on the etiology of trigeminal neuralgia.  Methods:  documentary review through an automated search in the databases PubMed/Medline, Cochrane Library, Scielo, Medigraphic and Science Direct, using the Google Scholar search engine, during the period from March 2021 to the same month of 2022. Thirty-one articles related to the proposed objective were selected; 23 (74.2%) are updated.  Results:  the causal factors of trigeminal neuralgia (trauma, infectious diseases and compression by neighboring anatomical structures or tumors) promote an inflammatory process in the connective tissue that composes the nerve, the release of leukocyte products causes its destruction and the nervous tissue is exposed; action potentials are triggered that cause the painful symptoms typical of the disease.  Conclusions:  the development of an inflammatory process in the connective tissue constituent of the trigeminal nerve causes a decrease in the excitability threshold of the affected fibers and provokes pain in response to different stimuli.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="es"><![CDATA[neuralgia]]></kwd>
<kwd lng="es"><![CDATA[trigémino]]></kwd>
<kwd lng="es"><![CDATA[V par craneal]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
<kwd lng="en"><![CDATA[neuralgia]]></kwd>
<kwd lng="en"><![CDATA[trigeminal]]></kwd>
<kwd lng="en"><![CDATA[V cranial nerve]]></kwd>
</kwd-group>
</article-meta>
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