<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>2709-7927</journal-id>
<journal-title><![CDATA[Acta Médica del Centro]]></journal-title>
<abbrev-journal-title><![CDATA[Acta méd centro]]></abbrev-journal-title>
<issn>2709-7927</issn>
<publisher>
<publisher-name><![CDATA[Hospital Provincial Clínico Quirúrgico Universitario Arnaldo Milián Castro]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S2709-79272023000300557</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Hipertrofia congénita del epitelio pigmentario de la retina, un hallazgo casual]]></article-title>
<article-title xml:lang="en"><![CDATA[Congenital hypertrophy of the retinal pigment epithelium, a casual discovery]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Márquez Falcón]]></surname>
<given-names><![CDATA[Adonis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cabanes Goy]]></surname>
<given-names><![CDATA[Lidaisy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Clínico Quirúrgico Universitario &#8220;Arnaldo Milián Castro&#8221;  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2023</year>
</pub-date>
<volume>17</volume>
<numero>3</numero>
<fpage>557</fpage>
<lpage>563</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S2709-79272023000300557&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S2709-79272023000300557&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S2709-79272023000300557&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la hipertrofia congénita del epitelio pigmentario de la retina es un hamartoma congénito del epitelio pigmentario de la retina. Se observa como una lesión pigmentada del fondo de ojo típicamente benigna. En ocasiones, en su forma de presentación única-solitaria, puede confundirse con una lesión pigmentada maligna del fondo de ojo.  Información del paciente:  dos pacientes acudieron a la Consulta de retina del Hospital &#8220;Arnaldo Milián Castro&#8221; por diferentes enfermedades. Por protocolo se les realizó el examen de rutina y se les diagnosticó, de forma casual, una hipertrofia congénita del epitelio pigmentario de la retina en su variante única-solitaria.  Conclusiones:  la hipertrofia congénita del epitelio pigmentario de la retina en su forma de presentación única-solitaria no se asocia con alguna otra enfermedad ocular o sistémica. Su diagnóstico es casual, en un examen de rutina. Lo esencial es no confundirla con otras lesiones pigmentadas malignas del fondo de ojo. El seguimiento con retinografía a color y la observación periódica son lo recomendado.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  congenital hypertrophy of the retinal pigment epithelium is a congenital hamartoma of the retinal pigment epithelium. It is seen as a typically benign pigmented fundus lesion. Sometimes, in its single-solitary presentation, it can be confused with a malignant pigmented lesion of the fundus.  Patient information:  two patients attended the retina clinic of the &#8220;Arnaldo Milián Castro&#8221; Hospital for different diseases. Per protocol, they underwent routine examination and were diagnosed, by chance, with congenital hypertrophy of the retinal pigment epithelium in its unique-solitary variant.  Conclusions:  congenital hypertrophy of the retinal pigment epithelium in its single-solitary form of presentation is not associated with any other ocular or systemic disease. Its diagnosis is casual, in a routine examination. The essential thing is not to confuse it with other malignant pigmented lesions of the fundus. Follow-up with color retinography and periodic observation are recommended.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hipertrofia congénita del epitelio pigmentario de la retina]]></kwd>
<kwd lng="es"><![CDATA[diagnóstico]]></kwd>
<kwd lng="en"><![CDATA[congenital hypertrophy of the retinal pigment epithelium]]></kwd>
<kwd lng="en"><![CDATA[diagnosis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kiernan]]></surname>
<given-names><![CDATA[FD]]></given-names>
</name>
<name>
<surname><![CDATA[Tripathy]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Ortiz-Morales]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Vernon Stuart]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Bhagat]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Lim]]></surname>
<given-names><![CDATA[JI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital hypertrophy of the retinal pigment epithelium]]></article-title>
<source><![CDATA[American Academy of Ophthalmology. EyeWiki]]></source>
<year>2020</year>
<publisher-loc><![CDATA[San Francisco ]]></publisher-loc>
<publisher-name><![CDATA[American Academy of Ophthalmology]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Raval]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Dalal]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Doshi]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Multimodal imaging of congenital hypertrophy of retinal pigment epithelium (chrpe) lesions at different presentations]]></article-title>
<source><![CDATA[Ophthalmology Case Rep]]></source>
<year>2019</year>
<volume>3</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>1-4</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Steffen Novelli]]></surname>
<given-names><![CDATA[PC]]></given-names>
</name>
<name>
<surname><![CDATA[Stachewski Russo]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Real Martinez]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
<name>
<surname><![CDATA[Guilherme Campos]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The significance and interpretation of congenital hypertrophy of the retinal pigment epithelium (CHRPE) diagnosed in patients with Familial Adenomatous Polyposis: A review]]></article-title>
<source><![CDATA[New Front Ophthalmol]]></source>
<year>2018</year>
<volume>4</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>1-3</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cherney]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital hypertrophy of the retinal pigment epithelium]]></article-title>
<source><![CDATA[Ophthalmol Rep]]></source>
<year>2013</year>
<volume>6</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>55-9</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ireland]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Rodman]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Congenital Hypertrophy of Retinal Pigment Epithelium]]></source>
<year>2023</year>
<publisher-loc><![CDATA[Treasure Island (FL) ]]></publisher-loc>
<publisher-name><![CDATA[StatPearls Publishing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meyer]]></surname>
<given-names><![CDATA[CH]]></given-names>
</name>
<name>
<surname><![CDATA[Rodrigues]]></surname>
<given-names><![CDATA[EB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital Hypertrophy of the Retinal Pigment Epithelium]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Sadda]]></surname>
<given-names><![CDATA[SR]]></given-names>
</name>
<name>
<surname><![CDATA[Sarraf]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Freund]]></surname>
<given-names><![CDATA[KB]]></given-names>
</name>
<name>
<surname><![CDATA[Hinton]]></surname>
<given-names><![CDATA[DR]]></given-names>
</name>
<name>
<surname><![CDATA[Schachat]]></surname>
<given-names><![CDATA[AP]]></given-names>
</name>
<name>
<surname><![CDATA[Wilkinson]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
<name>
<surname><![CDATA[Wiedemann]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<source><![CDATA[Ryan's Retina]]></source>
<year>2022</year>
<edition>7</edition>
<page-range>2633-8</page-range><publisher-loc><![CDATA[Toronto ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Shanmugam]]></surname>
<given-names><![CDATA[PM]]></given-names>
</name>
<name>
<surname><![CDATA[Konana]]></surname>
<given-names><![CDATA[VK]]></given-names>
</name>
<name>
<surname><![CDATA[Ramanjulu]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Mishra]]></surname>
<given-names><![CDATA[KCD]]></given-names>
</name>
<name>
<surname><![CDATA[Sagar]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Simakurthy]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Ocular coherence tomography angiography features of congenital hypertrophy of retinal pigment epithelium]]></article-title>
<source><![CDATA[Indian J Ophthalmol]]></source>
<year>2019</year>
<volume>67</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>563-6</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vélez Montoya]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[García Aguirre]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital Hypertrophy of the Retinal Pigment Epithelium]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Torres Soriano]]></surname>
<given-names><![CDATA[ME]]></given-names>
</name>
<name>
<surname><![CDATA[García Aguirre]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gordon]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kon Graversen]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<source><![CDATA[Ophthalmology: Current and Future Developments. Diagnostic Atlas of Retinal Diseases]]></source>
<year>2017</year>
<volume>3</volume>
<page-range>195-201</page-range><publisher-loc><![CDATA[Sharjah, UAE ]]></publisher-loc>
<publisher-name><![CDATA[Bentham Science Publishers]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Amit]]></surname>
<given-names><![CDATA[SN]]></given-names>
</name>
<name>
<surname><![CDATA[Pushpanjali]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Smitesh]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital hypertrophy of retinal pigment epithelium (CHRPE) with typical 'bear track' presentation]]></article-title>
<source><![CDATA[J Ophthalmol Relat Sci]]></source>
<year>2019</year>
<volume>1</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>10-1</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zloto]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Moroz]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Vishnevskia-Dai]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital hypertrophy of retinal pigment epithelium]]></article-title>
<source><![CDATA[BMJ Case Rep]]></source>
<year>2020</year>
<volume>13</volume>
<numero>8</numero>
<issue>8</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zografos]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Congenital hypertrophy of the retinal pigment epithelium (RPE)]]></article-title>
<source><![CDATA[Acta Ophthalmologica]]></source>
<year>2013</year>
<volume>91</volume>
<numero>s252</numero>
<issue>s252</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
