<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7523</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina]]></journal-title>
<abbrev-journal-title><![CDATA[Rev cubana med]]></abbrev-journal-title>
<issn>0034-7523</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75232020000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La COVID-19: un reto para la salud mundial]]></article-title>
<article-title xml:lang="en"><![CDATA[COVID-19: a challenge for global health]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés Álvarez]]></surname>
<given-names><![CDATA[Karen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chao Pereira]]></surname>
<given-names><![CDATA[Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221;  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2020</year>
</pub-date>
<volume>59</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75232020000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75232020000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75232020000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La enfermedad producida por el Coronavirus 2019 ha impactado al mundo más allá de los límites de la salud pública a tres meses del diagnóstico del primer caso en China. En la actualidad afecta a 182 países, por lo que fue declarada pandemia por la Organización Mundial de la Salud.  Objetivo:  Revisar los aspectos clínico-epidemiológicos más importantes reportados sobre esta enfermedad.  Desarrollo:  La enfermedad se trasmite por las microgotas de saliva entre personas y por contacto con superficies contaminadas o heces. El periodo de incubación es hasta 14 días, en los cuales puede ocurrir trasmisión viral. Se caracteriza por un espectro sintomático variable, los pacientes pueden permanecer asintomáticos o presentar síntomas como fiebre, dolor de garganta, tos, anosmia y disnea. Aproximadamente 14 % de los casos presenta formas graves y 5 % evoluciona a estado crítico, asociado a complicaciones como el síndrome de distress respiratorio o shock séptico. El diagnóstico confirmatorio es a través de los estudios de reacción en cadena de polimerasa en tiempo real, en muestras respiratorias. No existe un tratamiento efectivo, aunque se emplean medicamentos, la mayoría de ellos como parte de ensayos clínicos.  Conclusiones:  Es un fenómeno sin precedentes en el último siglo en relación al número de personas y países que ha afectado y al impacto en las dinámicas sociales y económicas del mundo actual.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: The disease caused by Coronavirus 2019 has impacted the world beyond the limits of public health three months after the first case was diagnosed in China. It currently affects 182 countries; hence it is was declared a pandemic by the World Health Organization.  Objective: To review the most important clinical-epidemiological aspects reported on this disease.  Findings:  The disease is transmitted by droplets of saliva between people and by contact with contaminated surfaces or faeces. The incubation period is up to 14 days, in which viral transmission can occur. It is characterized by a variable symptom spectrum, patients can remain asymptomatic or present symptoms such as fever, sore throat, cough, anosmia and dyspnea. Approximately 14% of cases present severe forms and 5% progresses to a critical state, associated with complications such as respiratory distress syndrome or septic shock. The confirmatory diagnosis is through real-time polymerase chain reaction studies in respiratory samples. There is no effective treatment, although medications are used, most of them as part of clinical trials.  Conclusions: It is, in the last century, an unprecedented phenomenon regarding the number of people and countries it has affected and concerning the impact on the social and economic dynamics currently in the world.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[SARS-CoV2]]></kwd>
<kwd lng="es"><![CDATA[aspectos clínico-epidemiológicos]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[SARS-CoV2]]></kwd>
<kwd lng="en"><![CDATA[clinical-epidemiological aspects]]></kwd>
</kwd-group>
</article-meta>
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