<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0034-7531</journal-id>
<journal-title><![CDATA[Revista Cubana de Pediatría]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Pediatr]]></abbrev-journal-title>
<issn>0034-7531</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0034-75312022000200014</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Freeman-Sheldon]]></article-title>
<article-title xml:lang="en"><![CDATA[Freeman-Sheldon syndrome]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourt Castellanos]]></surname>
<given-names><![CDATA[Liset]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Jiménez Torres]]></surname>
<given-names><![CDATA[Idarmis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Izaguirre Bordelois]]></surname>
<given-names><![CDATA[Marioneya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Betancourt Castellanos]]></surname>
<given-names><![CDATA[Denny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Técnica de Manabí  ]]></institution>
<addr-line><![CDATA[ Manabí]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Gineco Obstétrico &#8220;Isidro Ayora&#8221;  ]]></institution>
<addr-line><![CDATA[ Pichincha]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Provincial &#8220;Antonio Luaces Iraola&#8221;  ]]></institution>
<addr-line><![CDATA[ Ciego de Ávila]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>94</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0034-75312022000200014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0034-75312022000200014&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0034-75312022000200014&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El síndrome de Freeman-Sheldon es un síndrome hereditario raro, de severidad variable que afecta principalmente la cara, manos y pies, sin preferencia de género, étnica o geográfica.  Objetivo: Caracterizar clínicamente a un paciente con síndrome Freeman-Sheldon.  Presentación del caso: Niña ecuatoriana de 6 años de edad, hija de madre de 43 años y padre de 42 años, la cuarta de 6 hermanos, todos sanos, no historia de consanguinidad. La cual presenta cara parecida a una máscara, ojos hundidos, puente nasal ancho, boca pequeña con apariencia de silbador, hoyuelo cutáneo en mentón en forma de H, defecto en las manos, contractura de los dedos con desviación cubital y pies equinovaro, dificultad para la marcha y baja talla.  Conclusiones: El síndrome de Freeman-Sheldon es un síndrome raro que afecta principalmente la cara y las extremidades de los pacientes, cuyo diagnóstico clínico es posible luego de un examen físico exhaustivo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Freeman-Sheldon syndrome is a rare hereditary syndrome of varying severity that mainly affects the face, hands and feet, without gender, ethnic or geographical preference.  Objective:  Clinically characterize a patient with Freeman-Sheldon syndrome.  Presentation of the case:  Ecuadorian girl, 6 years old, daughter of mother of 43 years and father of 42 years, the fourth of 6 brothers, all healthy, not history of consanguinity. She presents mask-like face, sunken eyes, wide nasal bridge, small mouth with the appearance of a whistler, skin dimple on the chin in the shape of an H, defect in the hands, contracture of the fingers with ulnar deviation and clubfoot, also walking difficulty and short height.  Conclusions:  Freeman-Sheldon syndrome is a rare syndrome that mainly affects the face and limbs of patients, whose clinical diagnosis is possible after a thorough physical examination.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[síndrome de Freeman-Sheldon]]></kwd>
<kwd lng="es"><![CDATA[síndrome de Freeman-Burian]]></kwd>
<kwd lng="es"><![CDATA[displasia craneocarpotarsal]]></kwd>
<kwd lng="es"><![CDATA[distrofia craneocarpotarsal]]></kwd>
<kwd lng="es"><![CDATA[síndrome craneofacial]]></kwd>
<kwd lng="es"><![CDATA[artrogriposis distal tipo 2A]]></kwd>
<kwd lng="es"><![CDATA[síndrome de cara de silbido]]></kwd>
<kwd lng="en"><![CDATA[Freeman-Sheldon syndrome]]></kwd>
<kwd lng="en"><![CDATA[Freeman-Burian syndrome]]></kwd>
<kwd lng="en"><![CDATA[craniocarpotarsal dysplasia]]></kwd>
<kwd lng="en"><![CDATA[craniocarpotarsal dystrophy]]></kwd>
<kwd lng="en"><![CDATA[craniofacial syndrome]]></kwd>
<kwd lng="en"><![CDATA[distal arthrogryposis type 2A]]></kwd>
<kwd lng="en"><![CDATA[whistling face syndrome]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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