<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0289</journal-id>
<journal-title><![CDATA[Revista Cubana de Hematología, Inmunología y Hemoterapia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></abbrev-journal-title>
<issn>0864-0289</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-02892020000200003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[El dolor en la drepanocitosis]]></article-title>
<article-title xml:lang="en"><![CDATA[Pain in sickle cell disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Concepción Fernández]]></surname>
<given-names><![CDATA[Yusleidy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Agramonte Llánes]]></surname>
<given-names><![CDATA[Olga Margarita]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quintero Sierra]]></surname>
<given-names><![CDATA[Yamilé]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Hematología e Inmunología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>36</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-02892020000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-02892020000200003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-02892020000200003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La drepanocitosis incluye un grupo de desórdenes genéticamente heredados en los que a baja saturación de oxígeno ocurre la agregación de polímeros rígidos de hemoglobina S desoxigenada. El dolor es la principal característica clínica de la enfermedad drepanocítica, constituye la primera causa de hospitalización; es básicamente de tipo nociceptivo. Los pacientes con drepanocitosis pueden presentar varios tipos de dolor en dependencia de las estructuras lesionadas, el de tipo músculo-esquelético es el más frecuente.  Objetivo: Analizar las principales modalidades terapéuticas para el manejo del dolor en la drepanocitosis.  Métodos: Se realizó una revisión de la literatura, en inglés y español, a través del sitio web PubMed y el motor de búsqueda Google académico de artículos publicados en los últimos 5 años. Se hizo un análisis y resumen de la bibliografía revisada.  Análisis y síntesis de la información:  Actualmente existen varias opciones de tratamiento. La base del manejo del dolor es el reconocimiento y la evaluación de la gravedad, ya que de esta dependerá el tratamiento analgésico. Una vez instaurado el dolor, el manejo inicial debe enfocarse en proveer control rápido, garantizar las dosis terapéuticas de los fármacos y evitar la aparición de complicaciones.  Conclusión: Se debe mantener un adecuado tratamiento y seguimiento de los pacientes con dolor en la drepanocitosis, pues esto permitirá disminuir en lo posible las complicaciones que pueden ocasionar la enfermedad en los pacientes desde el punto de vista orgánico y psicológico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Sickle cell disease includes a group of genetically inherited disorders in which, at low oxygen saturation, aggregation of rigid polymers of deoxygenated hemoglobin S occurs. Pain is the main clinical characteristic of sickle cell disease. It is the first cause of hospitalization. It is basically of nociceptive type. Patients with sickle cell disease can present various types of pain depending on the injured structures; the musculoskeletal type is the most frequent.  Objective:  To analyze the main therapeutic modalities for pain management in sickle cell disease.  Methods:  A literature review was carried out, in English and in Spanish, through the PubMed website and the Google Scholar search engine, of articles published in the last five years. Analysis and summary of the revised bibliography was made.  Information analysis and synthesis:  Currently, there are several treatment options. The basis for pain management is the recognition and evaluation of severity, since analgesic treatment will depend on this. Once pain is established, initial management should focus on providing rapid control, guaranteeing therapeutic doses of drugs, and avoiding the onset of complications.  Conclusion:  Adequate treatment and follow-up of patients with pain in sickle cell disease should be maintained, as this will reduce, as much as possible, the complications that the disease can cause in patients from an organic and psychological point of view.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[drepanocitosis]]></kwd>
<kwd lng="es"><![CDATA[microcirculación]]></kwd>
<kwd lng="es"><![CDATA[dolor]]></kwd>
<kwd lng="en"><![CDATA[sickle cell disease]]></kwd>
<kwd lng="en"><![CDATA[microcirculation]]></kwd>
<kwd lng="en"><![CDATA[pain]]></kwd>
</kwd-group>
</article-meta>
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