<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002019000300004</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[IgG anti-Toxoplasma gondii antibody index as a measure of the naturally-acquired immune intrathecal response in a neuroepidemiological study]]></article-title>
<article-title xml:lang="es"><![CDATA[Indice de anticuerpos IgG anti-Toxoplasma gondii como medida de la respuesta inmune intratecal adquirida naturalmente según un estudio neuroepidemiológico]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Quevedo]]></surname>
<given-names><![CDATA[Mileydis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo González]]></surname>
<given-names><![CDATA[William]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorta Contreras]]></surname>
<given-names><![CDATA[Alberto Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Instituto de Ciencias Básicas y Preclínicas &#8220;Victorias de Girón&#8221; ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad de Ciencias Médicas &#8220;Miguel Enríquez&#8221; ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Facultad de Ciencias Médicas &#8220;Miguel Enríquez&#8221; Laboratorio Central de Líquido Cefalorraquídeo (LABCEL) ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002019000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002019000300004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002019000300004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The presence of IgG anti-Toxoplasma gondii has been used as an indicator to measure the naturally-acquired immune intrathecal response due to the polyclonal and polyspecific intrathecal response developed in neuroinflammation processes. The absence of anti-Toxoplasma gondii antibodies in a subject who had been exposed to the parasite could be seeded as immunocompromised. The aim of the study is determine cases of autoimmunity and immunodeficiency.  Objective: Demonstrate whether the IgG anti-Toxoplasma gondii antibody index can be used as an indicator of a population immune status seen through patients with neuroinflammatory processes.  Methods: Cerebrospinal fluid (CSF) and serum samples were taken from 64 pediatric patients with intrathecal synthesis of antibodies and IgG anti-Toxoplasma gondii antibody indexes (AI) were determined.  Results: The sample was divided in three intervals according to Hansotto Reiber investigations (&#8804;0.6; 0.6-1.5; &#8805;1.5) and a mean interval ±1SD between 0.23 and 1.12. The groups were quite similar regarding to clinic and demographic characteristics; there were statics differences on anti-Toxoplasma gondii AI (p&lt;0.01) and the presence of domestic animals (p=0.04). In the group with AI&#8805;1.5, the 83.3% had positive the Measles-Rubella-Zoster reaction, indicative of active autoimmune disease. On the group with AI&#8804;0.6 were analyzed six different variables trying to find possible cases with immunodeficiencies: risk factors to contract toxoplasmosis; subjective clinical of immunocompromise; a test to detect immunodeficiencies; response against vacunal antigens and humoral response determined by IgG levels in serum. The immunodeficiencies test was the variable with higher statistical significance (p= 0.047).  Conclusions: The conclusion was that is possible to find subjects with autoimmune disorder and other ones with immunocompromise through the IgG anti-Toxoplasma gondii index by the developed investigation strategy.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La presencia de IgG anti-Toxoplasma gondii se ha utilizado como indicador para medir la respuesta inmune intratecal adquirida naturalmente, debido a la respuesta intratecal poliespecífica y policlonal que se produce en los procesos neuroinflamatorios. La ausencia de anticuerpos anti-Toxoplasma gondii en un sujeto que ha estado expuesto al parásito se puede ver como un caso de inmunocompromiso.  Objetivo:  Determinar casos de autoinmunidad e inmunodeficiencia.  Métodos:  Se tomaron muestras de líquido cefalorraquídeo (LCR) y suero de 64 pacientes pediátricos con síntesis intratecal de anticuerpos y se determinaron los índices de anticuerpos (IA) IgG anti-Toxoplasma gondii.  Resultados:  La muestra se dividió en tres intervalos según las investigaciones de Hansotto Reiber (·0,6; 0,6-1,5; ·1,5) y un intervalo medio ±1DE entre 0,23 y 1,12. Los grupos eran bastante similares en cuanto a sus características clínicas y demográficas, pero mostraban diferencias estadísticas en sus índices de anticuerpos anti-Toxoplasma gondii (p&lt; 0,01) y la presencia de animales domésticos (p= 0,04). En el grupo con IA·1,5, el 83,3% tuvo una reacción positiva al sarampión-rubéola-zóster, lo que indica la presencia de enfermedad autoinmune activa. En el grupo con IA·0,6 se analizaron seis variables diferentes, tratando de encontrar posibles casos de inmunodeficiencia: factores de riesgo de contraer toxoplasmosis, historia clínica subjetiva de inmunocompromiso, una prueba para detectar inmunodeficiencias, respuesta ante antígenos vacunales y respuesta humoral determinada por niveles de IgG en suero. La prueba de inmunodeficiencias fue la variable que mostró la mayor significación estadística (p= 0,047).  Conclusiones:  Se concluye que es posible encontrar sujetos con trastornos autoinmunes y otros con inmunocompromiso a partir del índice de IgG anti- Toxoplasma gondii siguiendo la estrategia de investigación elaborada.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[Toxoplasma gondii]]></kwd>
<kwd lng="en"><![CDATA[neuroimmunology]]></kwd>
<kwd lng="en"><![CDATA[antibody index]]></kwd>
<kwd lng="en"><![CDATA[immunodeficiency]]></kwd>
<kwd lng="en"><![CDATA[autoimmunity]]></kwd>
<kwd lng="es"><![CDATA[Toxoplasma gondii, neuroinmunología]]></kwd>
<kwd lng="es"><![CDATA[índice de anticuerpos]]></kwd>
<kwd lng="es"><![CDATA[inmunodeficiencia]]></kwd>
<kwd lng="es"><![CDATA[autoinmunidad]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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