<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002021000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico de la dinámica cardiaca mediante proporciones de la entropía]]></article-title>
<article-title xml:lang="en"><![CDATA[Heart dynamics diagnosis based on entropy proportions]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Velásquez]]></surname>
<given-names><![CDATA[Javier Oswaldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Correa]]></surname>
<given-names><![CDATA[Catalina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
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<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramirez]]></surname>
<given-names><![CDATA[Leonardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
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<contrib contrib-type="author">
<name>
<surname><![CDATA[Santos Restrepo]]></surname>
<given-names><![CDATA[Angie Nicole]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Riaño Rodriguez]]></surname>
<given-names><![CDATA[Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bacca Porras]]></surname>
<given-names><![CDATA[Marco Alfredo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Militar Nueva Granada Centro de Investigaciones Clínicas del Country ]]></institution>
<addr-line><![CDATA[Bogotá ]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2021</year>
</pub-date>
<volume>40</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002021000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002021000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002021000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Los valores de la frecuencia cardiaca normales y anormales registrados en los equipos electrocardiográficos ambulatorios o continuos han sido caracterizados mediante nuevas metodologías diagnósticas, las cuales se han desarrollado en el contexto de la teoría de los sistemas dinámicos y la entropía.  Objetivo: Evaluar la dinámica cardiaca de adultos, teniendo en cuenta su comportamiento en el contexto de la teoría de sistemas dinámicos y las proporciones de la entropía mediante un estudio ciego.  Métodos: Se realizó una prueba diagnóstica mediante un estudio ciego de 500 Holter, aplicando una nueva metodología basada en las proporciones de la entropía del atractor numérico construido con los valores registrados en el Holter. Para esto, los valores máximos y mínimos de la frecuencia cardiaca para cada hora, así como el número de latidos, fueron tomados de cada Holter durante, mínimo, 18 horas. Con estos valores se generó un atractor numérico que cuantificó la probabilidad de parejas de frecuencias cardiacas consecutivas. Se evaluó cada dinámica a partir de los valores de entropía y de sus proporciones. Posteriormente, estos resultados fueron comparados con la evaluación clínica convencional estimando la sensibilidad y especificidad, así como el coeficiente Kappa.  Resultados: Se encontraron diferencias entre la dinámica de casos normales y anormales, en las dinámicas cardiacas evaluadas en 18 horas, hallando valores de sensibilidad y especificidad del 100 % y coeficiente Kappa de uno, respecto al diagnóstico clínico convencional.  Conclusiones: Los valores de entropía y de sus proporciones permiten diferenciar cuantitativamente la normalidad de la enfermedad en la dinámica cardiaca, durante un mínimo de 18 horas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: The normal and abnormal heart rate values recorded on ambulatory or continuous electrocardiographic devices have been characterized with novel diagnostic methodologies developed in the context of dynamic systems and entropy theory.  Objective: Through a blind study, evaluate the heart dynamics of adults taking into account their behavior in the context of dynamic systems theory and entropy proportions.  Methods: A diagnostic test was conducted through a 500 Holter blind study, applying a novel methodology based on the entropy proportions of the numerical attractor constructed with the values registered on the Holter device. To achieve this end, maximum and minimum heart rate values for each hour, as well as the number of beats, were obtained from each Holter device for at least 18 hours. Based on these values, a numerical attractor was generated which quantified the probability of consecutive heart rate pairs. Each dynamic was evaluated in terms of entropy values and their proportions. These results were then compared with the conventional clinical evaluation, estimating the sensitivity and specificity as well as the kappa coefficient.  Results: Differences were found between the dynamics of normal and abnormal cases, in the heart dynamics evaluated in 18 hours, finding sensitivity and specificity values of 100% and a kappa coefficient of 1, with respect to conventional clinical diagnosis.  Conclusions: Entropy values and their proportions make it possible to quantitatively differentiate the normality of the disease in heart dynamics for a minimum of 18 hours.]]></p></abstract>
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<kwd lng="es"><![CDATA[diagnóstico]]></kwd>
<kwd lng="es"><![CDATA[sistemas no lineales]]></kwd>
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<kwd lng="es"><![CDATA[entropía]]></kwd>
<kwd lng="es"><![CDATA[cardiología]]></kwd>
<kwd lng="en"><![CDATA[diagnosis]]></kwd>
<kwd lng="en"><![CDATA[non-linear systems]]></kwd>
<kwd lng="en"><![CDATA[mathematics]]></kwd>
<kwd lng="en"><![CDATA[entropy]]></kwd>
<kwd lng="en"><![CDATA[cardiology]]></kwd>
</kwd-group>
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