A method for ascertaining the quality of cancer registry data

Arduino Verdecchia,1 Roberta De Angelis,1 Silvia Franceschi1

Summary

Methods commonly used to evaluate completeness and quality of CR data involve simple and indirect indicators such as the proportion of DCO cases, the proportion of cases with microscopic confirmation, the incidence to mortality ratio, etc. Modelling cancer incidence, mortality and survival in a unified framework is proposed as an appropriate approach to check for consistency CR data with a process that turns out to be circular if, and only if, mortality, incidence and patients’ survival data are high quality and complete. The MIAMOD method was developed to provide incidence, prevalence and mortality estimates and projections, using mortality and patients’ survival information at national or regional levels. Examples of application of the MIAMOD method to national cancer registries in Europe are given to show the performance of the method in checking the CR data for internal consistency and completeness of registration. We are proposing the MIAMOD method and software as a tool for CR useful to check for completeness and quality of their data and to provide future cancer burden information for health planning and allocation of resources for their area.

Key words: Epidemiological methods, Cancer, Incidence, Mortality.

Introduction

Cancer registries (CR) represent epidemiological instruments which are aimed at providing population based cancer incidence and mortality. Cancer registries need well recognized requisites to be classified as high quality CR, and to be efficient tools for cancer control. Quality and completeness of data collected by cancer registries represent key issues that affect their reliability and potential use of their data. When cancer patients’ survival and prevalence are additional aims for a CR, further control is needed on completeness and quality of follow-up of patients for life status.

Methods commonly used to evaluate the completeness and quality of CR data involve simple and indirect indicators such as the proportion of DCO cases, the proportion of cases with microscopic confirmation, the mortality to incidence ratio, etc. However, none one of these indicators must be taken individually for ascertaining the completeness and quality of collected data. For example, the mortality to incidence ratio is not expected to be constant in time as it strongly depends on the shape of incidence and mortality trend curves, according to their stable, increasing, decreasing or changing patterns. The proportion of DCO cases can certainly inform us about the completeness of the collecting system but it does not give any information on the quality of diagnoses, dates, and the entity of all information collected.

Modeling cancer incidence, mortality and survival in a unified framework is, in principle, an appropriate approach to check for consistency of CR data. This kind of models establishes the theoretical relationships between the different quantities involved in the process to which the same cancer patients contribute. We can check whether incidence is consistent with mortality and patients’ survival in a process that turns out to be circular if, and only if all the data, are of high quality and highly complete.

Aim of this paper is to propose the MIAMOD method and software as a useful tool for CRs who wish to perform their own check for completeness and quality of their data. CRs can also use the method to produce estimates and projections of cancer incidence, mortality and prevalence for their area.

Methods

The MIAMOD method was extensively presented in previous papers.1,2 We will present here its basic formulation and explain understandably how thise method performs.

FIG. 1. The MIAMOD method: compartmental representation for a given birth cohort.

with cancer at age t , and b and a are the death hazard for cancer patients and death hazard for the general population, respectively. Equation (1) gives the expected cancer mortality at age x as the convolution of the probability of cancer diagnosis m(t) at age t<x, for the proportion of healthy people in the population, [1-n(t)], times the probability of death from cancer at age x, conditional to have survived the extra death hazard for cancer patients with respect to the general population.

The second equation gives similarly the cancer prevalence n(x) at age x as the convolution the probability of cancer diagnosis m(t) at age t<x, for the proportion of healthy people in the population, times the probability of surviving the extra death hazard for cancer patients with respect to the general population. A set of equation systems (1 and 2), one for each N=A+Y birth cohorts involved in the data for A single year of age, and Y single year of diagnosis, allows functionally for a link function G(m) between cancer incidence and mortality. Figure 2 show the data space for the MIAMOD method, including the back projection, estimation and projection areas. For each birth cohort the data matrix describes only a variable part of it and some back projection and forward projection is implied in the age period and cohort approach. In the projection area no data are available for the future birth cohort and a limit to 10-20 years of projection period should be defined in order to moderate the progressive bias of missing future birth cohorts. ]]>

Incidence is assumed as a polynomial function of age, period of diagnosis and birth cohort, throughout a logit link function F:

FIG. 2. The MIAMOD method data space.

where q = (const , a1, …, ak1, b1, …, bk2, c1, …, ck3) is the vector of the parameters to be estimated by a maximum likelihood fit of cancer mortality data matrix by single year of age and calendar year of diagnosis. The function F works as a link function between incidence and mortality. Also the degree of polynomials have to be estimated. A set of restricted cubic splines3 can be used to model either age, period and cohort as an alternative to polynomials.

In a CR data application, whether or not the expected incidence matches the observed one, we can derive indications on the completeness and quality of CR data. If observed and expected data match we simply conclude that the CR data area high quality and complete. If they do not match we have to further study in detail all the information involved and to discriminate which of the information is likely to be problematic. Hence we must try to identify the ways to improve the data. The lack of consistency between incidence, mortality and survival can derive from problems of (in)completeness of cancer registration, misclassification of incidence or deaths cases. If a registry misses randomly a proportion of cases, the estimated patients’ survival is not expected to be biased. In this case the lack of match of the observed and expected incidence expresses the proportion of missing incidence cases. If misclassification of the cancer site occurs frequently for collected incidence cases, the estimated patients’ survival will reflect this biased disease definition of incidence cases that is expect to apply differently to mortality data. The lack of match between the observed and expected incidence in this case expresses the combined action of incidence misclassification and the corresponding patients’ survival bias. Then, we expect that the observed and estimated cancer incidence will match perfectly if and only if all the involved data are complete and high quality.

The method needs this patients’ survival information over a long span of calendar years in order to cover potentially the entire data space (Figure 2). Survival data are usually available from CRs for a limited time period which depend on how long the CR has been operating. Some modeling of survival is then needed to expand the survival information both to long term and backward to former calendar years.

Example applications

The MIAMOD method was extensively applied to national level in Italy.6-10 to European countries within a concerted action of the EU commission, the EUROPREVAL Study, to the major cancer sites (Franceschi S, De Angelis R, Quinn M, Colonna M, Verdecchia A. Changing trend in lung cancer in Europa [in press] in and to US (Verdecchia A, Mariotto A, Micheli A, Ries LAG, Lynch CF,Yancik R. Estimating and projecting the prevalence of cancer: an Application to Iowa Cancer Registry data [in press]. The method was also applied to rather small areas, e.g. Iceland, local CR areas,11 Italian regions,12-14 and rare cancer sites.

We will present in this section some example application from the EUROPREVAL experience which illustrate how the method performs and may be used to check CR data for their consistency.

Application to high quality CR

FIG. 3. Example applications to high quality national CR a) Prostate cancer in Sweden; b) Male colorectal cancer in Iceland; c) Male colorectal in Estonia; d) Male lung cancer in Finland.

Managing inconsistencies

When the comparison of observed and estimated incidence results in no satisfactory match, some further study is required to identify the reasons for these inconsistencies. We present some example situations with identified problems.

Figure 4 shows observed and estimated male lung cancer incidence and mortality in Sweden.

FIG. 4. Male lung cancer in Sweden. Comparison of observed and estimated incidence and mortality rates.

Figure 5 shows observed and estimated incidence and mortality trends for breast cancer in Scotland. Breast cancer incidence in Scotland presents a bump just following the year 1990 that is not reflected in the mortality trend and not reproduced by the estimated incidence. This is a very clear illustration of the effect, which the introduction of the population based breast cancer screening had on England and Scotland in 1990.15 After the bump, the incidence trend continued exactly as expected by the MIAMOD method. So in this case, the MIAMOD application served to quantify the artifact incidence effect of the screening we can evaluate by the area of the bump.

FIG. 5. Female breast cancer in Scotland. Comparison of observed and estimated incidence and mortality rates.

TABLE. Lung cancer in Sweden. Comparison of corrected observed incidence (EUROCIM-rates§*) and MIAMOD estimated incidence (MIAMOD- rates§)

§ Rates per 100,000 population.
* Corrected with the number of DCO cases.

Discussion

We proved that the MIAMOD method is a flexible and valid procedure to produce estimates and projections of incidence and prevalence, provided that valid mortality and survival information is available. The method can be also applied to rather small CR areas.

When used to check and validate CR data the method allows for a comprehensive evaluation of the consistency of incidence, mortality and patients’ survival information that is integrative to other conventional methods currently used for data quality check. The MIAMOD application is not simply a check of the data as it heavily involves the analysis and use of the data. The application may result in a perfect match between the observed and estimated cancer incidence on the basis that all data are high quality and complete. For problems arising from an unsatisfactory match between observed and estimated cancer incidence we need to study in detail all possible reasons, i.e. patients selections, inconsistencies in the disease definition between incidence and mortality orother misclassifications, biases in the survival analysis and modeling, screenings, etc. Managing inconsistencies involves further studies on the quality and completeness of the CR data that certainly have the effect of improving the quality of the data.

The MIAMOD software, equipped with a very user friendly interface is available, free of charge, on request to Dr. Roberta De Angelis (e-mail: rodeange@iss.it). Using the method correctly, however requires some statistical and modelling knowledge, in addition to these basic features explained.

A first introductory course on modeling cancer incidence and mortality with MIAMOD will be organized in Italy, early December 2003. Other courses will follow on the basis of interest. Readers interested in further information on the MIAMOD software and courses may feel free to contact Dr. Roberta De Angelis, email: rodeange@iss.it.

RESUMEN

Los métodos que habitualmente se utilizan para evaluar el completamiento y la calidad de las informaciones del Registro del Cáncer comprenden indicadores sencillos e indirectos como son la proporción de casos con certificados de defunción (casos DCO), la proporción de casos con confirmación microscópica, la relación incidencia-mortalidad, etc. Se propone en este trabajo la modelación de la incidencia del cáncer, la mortalidad y la supervivencia en un marco unificado como método adecuado para chequear la consistencia de las informaciones del Registro del Cáncer con un proceso que se cierra solo cuando los datos sobre mortalidad, incidencia y supervivencia del paciente son completos y tienen una gran calidad. El método MIAMOD se desarrolló para brindar estimados y proyecciones referidos a la incidencia, prevalencia y mortalidad, utilizando la información sobre mortalidad y supervivencia de los pacientes a nivel nacional o regional. Se ofrecen ejemplos de la aplicación del método MIAMOD en los registros nacionales del cáncer en Europa para mostrar el comportamiento del método en la revisión de las informaciones del Registro del Cáncer en lo que respecta a la consistencia interna y el completamiento de la información. Proponemos el método y el software MIAMOD como una herramienta útil para chequear el completamiento y la calidad de las mencionadas informaciones y para brindar información futura sobre el peso del cáncer en los planes de salud y en la asignación de recursos para esta esfera.

Palabras clave: Metodos epidemiologicos, cAncer, incidencia, mortalidad.

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1 Medical Doctor. Epidemiology y Bioestatistic.