<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552018000500677</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[La toxina botulínica como alternativa de tratamiento en pacientes con acalasia]]></article-title>
<article-title xml:lang="en"><![CDATA[Botulinum toxin as an alternative treatment in patients with achalasia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas Peláez]]></surname>
<given-names><![CDATA[Yosvany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Trujillo Pérez]]></surname>
<given-names><![CDATA[Yon Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Brito Adam]]></surname>
<given-names><![CDATA[Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Menéndez Estrada]]></surname>
<given-names><![CDATA[Everto Daniel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chiong Quesada]]></surname>
<given-names><![CDATA[Martín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Policlínico Docente José Martí de Camagüey  ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Ciencias Médicas de Camagüey Hospital Provincial Amalia Simoni ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Provincial Universitario Manuel Ascunce Domenech de Camagüey  ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>5</numero>
<fpage>677</fpage>
<lpage>693</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552018000500677&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552018000500677&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552018000500677&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  dentro de las enfermedades que afectan al esófago se encuentra la acalasia. A pesar de no existir ningún tratamiento curativo para esta enfermedad, sí existen varias estrategias terapéuticas paliativas; en los últimos años se habla cada vez más del uso de la toxina botulínica.  Objetivo:  evaluar la efectividad de la toxina botulínica como alternativa de tratamiento en pacientes con acalasia en Camagüey.  Métodos: se realizó un estudio descriptivo, de corte longitudinal y prospectivo. El universo de estudio ascendió a un total de 13 pacientes. Los datos se plasmaron en una ficha de recolección. Para mejor comprensión la información se mostró en tablas.  Resultados: se negaron a recibir otro tratamiento, seis pacientes, para un 46,15 %. Se evidenció un resultado satisfactorio de esta opción terapéutica a corto plazo en el 100 %. No aparecieron recidivas de la enfermedad durante los primeros seis meses del realizado el tratamiento, en ninguno de los pacientes. Más de la mitad de los casos tratados no presentaron reacciones adversas, con un 61,54 %.  Conclusiones:  el tratamiento se aplicó ante la negativa de la mayoría de los pacientes para recibir otra opción terapéutica. La evaluación a corto plazo evidenció que la totalidad de los pacientes refirió estar asintomático, y aparecieron recidivas entre los nueve y 12 meses. Predominaron los pacientes que no presentaron efectos adversos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: achalasia is found among the diseases that affect the esophagus. Although there is no curative treatment for this disease, there are several palliative therapeutic strategies; in recent years the use of botulinum toxin has been increasingly discussed.  Objective: to evaluate the effectiveness of botulinum toxin as an alternative treatment in patients with achalasia in Camagüey.  Methods: a descriptive, longitudinal and prospective study was carried out. The study universe increased to a total of 13 patients. The data was recorded in a collection form. For better understanding the information was shown in tables.  Results: six patients, for 46.15 % refused to receive another treatment. A satisfactory result of this short-term therapeutic option was found in 100 %. There were no recurrences of the disease during the first six months of the treatment, in none of the patients. More than half of the treated cases did not present adverse reactions, with 61.54 %.  Conclusions:  the treatment was applied when most of the patients refused to receive another therapeutic option. The short-term evaluation showed that all patients reported being asymptomatic, and recurrences appeared between nine and 12 months. Patients who did not present adverse effects predominated.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ACALASIA DEL ESÓFAGO/tratamiento farmacológico]]></kwd>
<kwd lng="es"><![CDATA[ACALASIA DEL ESÓFAGO/diagnóstico]]></kwd>
<kwd lng="es"><![CDATA[TOXINAS BOTULÍNICAS/uso terapéutico]]></kwd>
<kwd lng="es"><![CDATA[TOXINAS BOTULÍNICAS/efectos de los fármacos]]></kwd>
<kwd lng="es"><![CDATA[EVALUACIÓN DE MEDICAMENTOS]]></kwd>
<kwd lng="en"><![CDATA[ESOPHAGEAL ACHALASIA/drug therapy]]></kwd>
<kwd lng="en"><![CDATA[ESOPHAGEAL ACHALASIA/diagnosis]]></kwd>
<kwd lng="en"><![CDATA[BOTULINUM TOXINS/therapeutic use]]></kwd>
<kwd lng="en"><![CDATA[BOTULINUM TOXINS /drug effects]]></kwd>
<kwd lng="en"><![CDATA[DRUG EVALUATION]]></kwd>
</kwd-group>
</article-meta>
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