<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552019000200249</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Hoffmann, manifestación de hipotiroidismo: presentación de un caso]]></article-title>
<article-title xml:lang="en"><![CDATA[Hoffmann syndrome, manifestation of hypothyroidism: presentation of a case]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramos-Cabrera]]></surname>
<given-names><![CDATA[Asmell]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Culay-Pérez]]></surname>
<given-names><![CDATA[Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Sánchez]]></surname>
<given-names><![CDATA[Yamila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gregori-Caballero]]></surname>
<given-names><![CDATA[Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Universitario Manuel Ascunce Domenech ]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>2</numero>
<fpage>249</fpage>
<lpage>255</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552019000200249&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552019000200249&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552019000200249&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  el síndrome de Hoffmann es definido como la combinación de hipotiroidismo con miopatía, rigidez, calambres e hipertrofia muscular. Dicha forma de miopatía tiroidea es rara y por lo general acompaña a los pacientes con hipotiroidismo severo y de larga evolución.  Objetivo:  describir un caso con características clínicas, hormonales y musculares de un síndrome de Hoffmann, como manifestación excepcional del hipotiroidismo.  Caso clínico:  paciente femenina, de 16 años de edad comienza a sentir molestias musculares dadas por dolores y fatiga, las cuales se incrementaron de manera progresiva, las mialgias se tornaron intensas al punto que no le permitían realizar esfuerzo físico alguno, con astenia marcada y luego se agregaron contracciones musculares dolorosas, lo que la motivó asistir a consulta médica. Asociadas a estas manifestaciones se encontraron niveles muy elevados de enzimas musculares. Se comprueba aumento de volumen de la glándula tiroides, así como síntomas y signos sugestivos de hipotiroidismo, el cual se confirma tras dosificaciones de la tirotropina, tiroxina y triyodotironina.  Conclusiones:  el caso que se presentó es característico del síndrome de Hoffmann, cuya historia clínica detallada y meticulosa evidenció la presentación del hipotiroidismo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Hoffmann syndrome is defined as the combination of hypothyroidism with myopathy, rigidity, cramps and muscle hypertrophy. This form of thyroid myopathy is rare and usually accompanies patients with severe and long-evolving hypothyroidism.  Objective:  to describe a case with clinic, hormonal and muscle characteristics of a Hoffmann syndrome, as an exceptional manifestation of hyperthyroidism.  Clinical case: 16-year-old, female patient begins to feel muscular discomfort due to pain and fatigue, which gradually increased, the myalgia became intense to the point that did not allow any physical effort, with marked asthenia and later contractions were added painful muscles, motivating her attendance to medical consultation. Associated with these manifestations were very high levels of muscle enzymes. Increased thyroid volume and symptoms and signs suggestive of hypothyroidism are confirmed, which is confirmed after dosages of thyrotropin, thyroxine and triiodothyronine.  Conclusions:  the presented case constitutes a characteristic example of the Hoffmann syndrome, which thanks to a detailed and meticulous clinical history showed the presentation of hypothyroidism.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[HIPOTIROIDISMO /tratamiento farmacológico]]></kwd>
<kwd lng="es"><![CDATA[HIPOTIROIDISMO/diagnóstico]]></kwd>
<kwd lng="es"><![CDATA[DEBILIDAD MUSCULAR/diagnóstico]]></kwd>
<kwd lng="es"><![CDATA[DISTROFIAS MUSCULARES /complicaciones]]></kwd>
<kwd lng="es"><![CDATA[INFORMES DE CASOS]]></kwd>
<kwd lng="en"><![CDATA[HIPOTIROIDISMO /tratamiento farmacológico]]></kwd>
<kwd lng="en"><![CDATA[HIPOTIROIDISMO/diagnóstico]]></kwd>
<kwd lng="en"><![CDATA[DEBILIDAD MUSCULAR/diagnóstico]]></kwd>
<kwd lng="en"><![CDATA[DISTROFIAS MUSCULARES /complicaciones]]></kwd>
<kwd lng="en"><![CDATA[INFORMES DE CASOS]]></kwd>
</kwd-group>
</article-meta>
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