<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552020000600007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Indicadores morfométricos del melanoma maligno de piel]]></article-title>
<article-title xml:lang="en"><![CDATA[Morfometric indicators in malignant skin melanoma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Oro-Pozo]]></surname>
<given-names><![CDATA[Yamila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leyva-Sánchez]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Rojas]]></surname>
<given-names><![CDATA[Pedro Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Holguín  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552020000600007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552020000600007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552020000600007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  el melanoma maligno es un tumor con una gran capacidad de invasión y de difícil tratamiento por su elevada agresividad y mortalidad, en este, los estudios morfométricos se hacen necesarios por el valor que aportan en el diagnóstico histológico para mejorar el pronóstico de la enfermedad.  Objetivo:  describir el comportamiento de indicadores morfométricos como el área nuclear, volumen nuclear y factor de forma nuclear.  Métodos: se realizó un estudio de serie de casos de 12 pacientes con el diagnóstico de melanoma maligno de piel en el período septiembre 2015 a septiembre 2017 en la provincia Holguín. Se emplearon métodos teóricos y empíricos, estos últimos basados en técnicas morfométricas, luego se realizó análisis estadístico de los datos obtenidos y se reflejaron en tablas.  Resultados:  el área y el volumen nuclear muestran valores pequeños. El factor de forma como indicador de pleomorfismo nuclear presentó valores superiores en los casos del estudio que en los descritos en la literatura.  Conclusiones:  el volumen nuclear muestra valores pequeños, lo que habla a favor de un comportamiento característico de tejido hiperplásico, al igual que el comportamiento del área nuclear, los valores del factor de forma nuclear indican menor pleomorfismo que el descrito en la literatura.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: malignant melanoma is an invasive tumour and difficult to treat due to its high level of mortality and aggressiveness, a morphometry study was required to provide a proper diagnosis of the disease.  Objective:  to describe the behavior of morphometric indicators as nuclear area, nuclear volume and nuclear shape factor.  Methods:  a case series study in 12 patients having malignant skin melanoma was carried out, in the period from September 2015 to September 2017 in Holguin Province. Theoretical and empirical methods were used; these last two methods were based on Morphometric techniques. Then a statistical analysis of the information obtained was performed and they were added on a chart.  Results: the area and nuclear volume showed low rate. The shape factor showed less levels of pleomorfism than the ones described in specialized literature.  Conclusions:  when low values of nuclear volume and nuclear area in malignant melanoma are found we are dealing with hyperplastic tissue. The same happens with the incidence of the nuclear area; the values of the nuclear shape factor evidenced less pleomorfi levels than the ones described in specialized literature.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[MELANOMA/diagnóstico]]></kwd>
<kwd lng="es"><![CDATA[MELANOMA/mortalidad]]></kwd>
<kwd lng="es"><![CDATA[MELANOMA/patología]]></kwd>
<kwd lng="es"><![CDATA[MELANOMA/terapia]]></kwd>
<kwd lng="es"><![CDATA[NEOPLASIAS CUTÁNEAS/diagnóstico]]></kwd>
<kwd lng="en"><![CDATA[MELANOMA/diagnosis]]></kwd>
<kwd lng="en"><![CDATA[MELANOMA/mortality]]></kwd>
<kwd lng="en"><![CDATA[MELANOMA/pathology]]></kwd>
<kwd lng="en"><![CDATA[MELANOMA/therapy]]></kwd>
<kwd lng="en"><![CDATA[SKIN NEOPLASMS/diagnosis]]></kwd>
</kwd-group>
</article-meta>
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