<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[Arch méd Camagüey]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552023000100072</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Regeneración celular en los defectos óseos segmentarios]]></article-title>
<article-title xml:lang="en"><![CDATA[Cell regeneration in the segmental bone defects]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bornot-Duránd]]></surname>
<given-names><![CDATA[Yandri]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer-Matos]]></surname>
<given-names><![CDATA[Gleibis Amparo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Militar Dr. Fermín Valdés Domínguez Servicio Ortopedia y Traumatología]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Pediátrico Octavio de la Concepción y de la Pedraja Servicio Terapia Intensiva Pediátrica]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552023000100072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552023000100072&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552023000100072&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción : Los defectos óseos segmentarios se producen por traumas de alta energía que ocasionan pérdida aguda de hueso, ocurren en forma subaguda durante el desbridamiento quirúrgico de una fractura expuesta y también pueden verse en casos crónicos como pseudoartrosis y osteomielitis, los que alteran la calidad de vida del paciente.  Objetivo : Presentar un paciente con defecto óseo segmentario secundario a pseudoartrosis hipertrófica de húmero derecho de 6,3 cm.  Caso clínico : Paciente masculino de 45 años de edad, raza blanca, sin antecedentes patológicos personales, que llega a nuestra consulta referido de otra institución de salud con diagnóstico de Pseudoartrosis hipertrófica de húmero derecho de tres años de evolución. Se realizó la técnica de inducción de membrana (Masquelet) la cual se combinó con la implantación de células madres adultas autólogas en el segundo tiempo quirúrgico. Se logró la consolidación ósea a las 12 semanas.  Conclusiones:  Dentro las variantes terapéuticas de los defectos óseos segmentarios se destaca la técnica de inducción de membrana que en combinación con el uso de la terapia celular constituye una opción prometedora, al necesitar un menor volumen de injerto, rápida consolidación además de una alternativa económica y de fácil elaboración sin gran complejidad tecnológica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Segmental bone defects are produced by high-energy traumas that cause acute bone loss, occur sub-acutely during surgical debridement of an exposed fracture, and can also be seen in chronic cases such as pseudarthrosis and osteomyelitis, drastically altering the quality of life of the patient.  Objective:  To present a patient with a segmental bone defect secondary to hypertrophic nonunion of the right humerus measuring 6.3 cm.  Case report:  A 45-year-old male patient, Caucasian, with no personal pathological history, who came to our office referred from another health institution with a diagnosis of hypertrophic pseudoarthrosis of the right humerus of 3 years of evolution. The membrane induction technique (Masquelet) is performed, which was combined with the implantation of autologous adult stem cells in the second surgical time. Bone union was achieved at 12 weeks.  Conclusions:  Within the therapeutic variants of the segmental bone defects, the membrane induction technique stands out, which in combination with the use of cell therapy constitutes a promising option, taking into account that a smaller graft volume is needed, rapid consolidation, as well as an economical alternative, and easy to make without great technological complexity.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[FRACTURA DEL HÚMERO/complicaciones]]></kwd>
<kwd lng="es"><![CDATA[MEDICINA REGENERATIVA]]></kwd>
<kwd lng="es"><![CDATA[CÉLULAS MADRE]]></kwd>
<kwd lng="es"><![CDATA[TRATAMIENTO BASADO EN TRASPLANTE DE CÉLULAS Y TEJIDOS]]></kwd>
<kwd lng="es"><![CDATA[INFORMES DE CASOS]]></kwd>
<kwd lng="en"><![CDATA[HUMERAL FRACTURES/complications]]></kwd>
<kwd lng="en"><![CDATA[REGENERATIVE MEDICINE]]></kwd>
<kwd lng="en"><![CDATA[STEM CELLS]]></kwd>
<kwd lng="en"><![CDATA[CELL-AND TISSUE-BASED THERAPY]]></kwd>
<kwd lng="en"><![CDATA[CASE REPORTS]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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