<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-028X</journal-id>
<journal-title><![CDATA[Vaccimonitor]]></journal-title>
<abbrev-journal-title><![CDATA[Vaccimonitor]]></abbrev-journal-title>
<issn>1025-028X</issn>
<publisher>
<publisher-name><![CDATA[Finlay Ediciones]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-028X2019000300110</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reguladores de la expresión de genes de Mycobacterium tuberculosis: implicaciones en la virulencia y persistencia en la tuberculosis latente]]></article-title>
<article-title xml:lang="en"><![CDATA[Regulators of Mycobacterium tuberculosis gene expression: implications in virulence and persistence in latent tuberculosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Méndez-López]]></surname>
<given-names><![CDATA[María Victoria]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Carabobo Facultad de Ciencias de la Salud Dpto. Clínico Integral, Escuela de Bioanálisis]]></institution>
<addr-line><![CDATA[Maracay ]]></addr-line>
<country>Venezuela</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>28</volume>
<numero>3</numero>
<fpage>110</fpage>
<lpage>120</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-028X2019000300110&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-028X2019000300110&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-028X2019000300110&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La tuberculosis pulmonar (TB) es un problema de salud pública a nivel mundial. La Organización Mundial de la Salud estimó para el año 2017 alrededor de 10 millones de personas enfermas y 1,3 millones de muertes. La facultad que posee MTB para modular la respuesta inmune, sobrevivir y persistir bajo el ambiente hostil en el hospedero y en la TB latente ha sido ampliamente investigada, y requiere de regulación y control de la expresión genética. El objetivo es presentar una revisión de las investigaciones relacionadas con los reguladores de la expresión de genes de MTB que están asociados con la virulencia, persistencia y supervivencia en la TB latente. Se hizo una revisión de las investigaciones de los últimos 20 años. Se concluye que MTB posee una maquinaria genética que controla la expresión de genes que participan en virulencia y persistencia, en respuesta a la hipoxia, estrés oxidativo, falta de nutrientes y pH ácido. Entre ellos, participan los sistemas de dos componentes, factores sigma y reguladores transcripcionales. En algunos casos se ha comprobado que funcionan interconectados como una red. Los hallazgos de las investigaciones aportan conocimientos para el descubrimiento de nuevos blancos para el desarrollo de drogas antituberculosas, nuevas vacunas y métodos de diagnóstico de la TB, con el propósito de proveer nuevas estrategias para el control de la enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Pulmonary tuberculosis (TB) is a public health problem worldwide. The World Health Organization estimated about 10 million sick people and 1.3 million deaths in 2017. The ability of MTB to modulate the immune response, survive and persist under the hostile environment in the host and in latent TB has been extensively investigated, and requires regulation and control of genetic expression. The objective is to present a review of research related to regulators of MTB gene expression that are associated with virulence, persistence and survival in latent TB. A review of the investigations of the last 20 years was made. Finally, it is concluded that MTB has a genetic machinery that controls the expression of genes that participate in virulence and persistence in response to hypoxia, oxidative stress, lack of nutrients and acidic pH. Among them, two-component systems, sigma factors and transcriptional regulators participate. It has been proven that they work interconnected as a network in some cases. The research findings provide insights for the discovery of new targets for the development of anti-tuberculosis drugs, new vaccines and methods for diagnosis of TB, with the purpose of providing new strategies for disease control.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[virulencia]]></kwd>
<kwd lng="es"><![CDATA[genes reguladores]]></kwd>
<kwd lng="es"><![CDATA[tuberculosis pulmonar]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[virulence]]></kwd>
<kwd lng="en"><![CDATA[regulator genes]]></kwd>
<kwd lng="en"><![CDATA[pulmonary tuberculosis]]></kwd>
</kwd-group>
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