<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192018000900970</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Tirosinemia de tipo 1 en un lactante]]></article-title>
<article-title xml:lang="en"><![CDATA[Type 1 Tyrosinemia in an infant]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Dinza]]></surname>
<given-names><![CDATA[Pablo Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ascanio Rodríguez]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Acosta Camacho]]></surname>
<given-names><![CDATA[Odelinda]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Infantil Sur &#8220;Dr. Antonio María Béguez César&#8221;, ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>22</volume>
<numero>9</numero>
<fpage>970</fpage>
<lpage>976</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192018000900970&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192018000900970&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192018000900970&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Se describe el caso clínico de una paciente de 2 meses de edad, quien nació a término y normopeso; se alimentaba con lactancia materna exclusiva y tuvo antecedente de 2 ingresos previos (anemia severa y catarro común). Fue hospitalizada en el Servicio de Terapia Intensiva del Hospital Infantil Sur &#8220;Dr. Antonio María Béguez César&#8221; por presentar edemas generalizados y ascitis, con evolución rápida hacia un cuadro de insuficiencia hepática aguda. Las pruebas metabólicas de orina y sangre permitieron confirmar el diagnóstico de tirosinemia de tipo 1. A pesar de brindarle la atención requerida, la paciente evolucionó desfavorablemente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The case report of a 2 months of age patient is described who was born at term and normal in weight; she fed with exclusive breast feeding and she had a history of 2 previous admissions (severe anemia and common cold). She was hospitalized in the Intensive Therapy Service of "Dr. Antonio María Béguez Caesar" Southern Pediatric Hospital due to widespread edemas and ascites, with a fast clinical course to an acute liver failure. The metabolic tests of urine and blood allowed to confirm the diagnosis of type 1 tyrosinemia. In spite of offering her the required care, the patient had an unfavourable clinical course.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[lactante]]></kwd>
<kwd lng="es"><![CDATA[alteración innata del metabolismo]]></kwd>
<kwd lng="es"><![CDATA[tirosinemia]]></kwd>
<kwd lng="es"><![CDATA[Servicio de Terapia Intensiva]]></kwd>
<kwd lng="en"><![CDATA[nursing infant]]></kwd>
<kwd lng="en"><![CDATA[innate change of metabolism]]></kwd>
<kwd lng="en"><![CDATA[tyrosinemia]]></kwd>
<kwd lng="en"><![CDATA[Intensive Therapy Service]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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