<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192019000400740</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Frasier en una adolescente: asociación con disgenesia gonadal y enfermedad renal crónica]]></article-title>
<article-title xml:lang="en"><![CDATA[Frasier Syndrome in an adolescent: association to gonadal dysgenesis and renal chronic disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[Yaribel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sardinas]]></surname>
<given-names><![CDATA[Rosa María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilera]]></surname>
<given-names><![CDATA[Yania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Infantil Norte Docente Dr. Juan de la Cruz Martínez Maceira ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>4</numero>
<fpage>740</fpage>
<lpage>747</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192019000400740&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192019000400740&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192019000400740&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Se describe el caso clínico de una adolescente de 16 años de edad, con aparente buen estado de salud, quien había sido atendida desde hacía 3 años aproximadamente en la consulta de Pediatría por presentar falta de desarrollo puberal, amenorrea primaria, así como aumento de volumen en miembros inferiores. Se le realizaron los exámenes complementarios pertinentes y dado el conjunto de elementos clínicos que presentaba, incluida una proteinuria significativa asociada a dismorfismos corporales e hipogenitalismo, se consultó el caso con un equipo multidisciplinario, integrado por nefrólogos, endocrinólogos, genetistas y psicólogos. Se le diagnosticó el síndrome de Frasier, como una asociación síndrome nefrótico-disgenesia gonadal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The case report of a 16 years adolescent with apparent good health state who had been attended approximately for 3 years in the Pediatrics service to present lack of puberal changes, primary amenorrhoea, as well as increase of volume in lower members is described. The pertinent and complementary examinations were carried out and taking into account the group of clinical elements she presented, including a significant proteinuria associated with corporal dysmorfisms and hypogenitalism, the case was exposed to a multidisciplinary team, formed by nephrologists, Endocrinology specialists, geneticists and psychologists. Frasier syndrome was diagnosed, associated to nephrotic syndrome and gonadal dysgenesis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[adolescente]]></kwd>
<kwd lng="es"><![CDATA[síndrome de Frasier]]></kwd>
<kwd lng="es"><![CDATA[síndrome nefrótico]]></kwd>
<kwd lng="es"><![CDATA[disformismo corporal]]></kwd>
<kwd lng="es"><![CDATA[proteinuria]]></kwd>
<kwd lng="es"><![CDATA[disgenesia gonadal]]></kwd>
<kwd lng="en"><![CDATA[adolescent]]></kwd>
<kwd lng="en"><![CDATA[Frasier syndrome]]></kwd>
<kwd lng="en"><![CDATA[neprhotic syndrome]]></kwd>
<kwd lng="en"><![CDATA[corporal dysformism]]></kwd>
<kwd lng="en"><![CDATA[proteinuria]]></kwd>
<kwd lng="en"><![CDATA[gonadal dysgenesis]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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